Cancer Stem Cell News Volume 9.39 | Oct 14 2020

    0
    34







    2020-10-14 | CSCN 9.39


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 9.39 – 14 October, 2020
    TOP STORY

    Jagged1-Notch1-Deployed
    Tumor Perivascular Niche Promotes Breast Cancer Stem Cell Phenotype through Zeb1

    Scientists demonstrated that, with direct cell-cell contact, tumor microenvironment-derived endothelial cells provided the Notch ligand Jagged1 to neighboring breast cancer stem cells, leading to Notch1-dependent upregulation of Zeb1.
    [Nature Communications]

    Full Article


    Bruno Silva-Santos shares his work on understanding the role of gamma delta T cells in cancer immunity. Watch the webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Prominin-1-Radixin
    Axis Controls Hepatic Gluconeogenesis by Regulating PKA Activity

    Investigators analyzed the levels of mRNA transcripts in serum‐starved primary WT and KO mouse hepatocytes using RNA sequencing data, and found that cyclic AMP response element‐binding protein target genes were downregulated.
    [EMBO Journal]

    AbstractGraphical Abstract

    Immune
    Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection

    Extracellular matrix-rich tumors exhibited a stem cell-like gene expression profile and superior tumor-initiating capacity, whereas such features were absent in responder tumors.
    [Cancer Immunology Research]

    AbstractFull Article

    SIRT1-Mediated
    Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness

    Investigators report that NAD-dependent deacetylase sirtuin-1 (SIRT1) signaling regulated colorectal cancer (CRC) stemness by enhancing expression of CD24, a CRC stemness promoter.
    [Cancer Research]

    Abstract

    SUV39H1 Regulates the Progression of MLL-AF9-Induced Acute Myeloid Leukemia

    Scientists found that SUV39H1 was down-regulated in a variety of leukemias, including MLL-r AML, as compared with normal individuals.
    [Oncogene]

    Full Article

    Megalencephalic
    Leukoencephalopathy with Subcortical Cysts 1 (MLC1) Promotes Glioblastoma Cell Invasion in the Brain Microenvironment

    The authors showed that Mlc1 was expressed in human stem-like glioblastoma (GBM) cells and was linked to the development of primary and recurrent GBM.
    [Oncogene]

    Abstract

    RASSF1A
    Inhibits PDGFB-Driven Malignant Phenotypes of Nasopharyngeal Carcinoma Cells in a YAP1-Dependent Manner

    Researchers observed that ras-association domain family protein1 isoform A (RASSF1A) expression inhibited the malignant phenotypes of nasopharyngeal carcinoma (NPC) cells. Stable silencing of RASSF1A in NPC cell lines induced self-renewal properties and tumorigenicity in vivo/in vitro and the acquisition of an invasive phenotype in vitro.
    [Cell Death & Disease]

    Full Article

    Single-Cell
    RNA-Sequencing Shift in the Interaction Pattern between Glioma Stem Cells and Immune Cells during Tumorigenesis

    Single-cell sequencing data from seven surgical specimens of glioblastoma patients and patient-derived glioma stem cells co-cultured with peripheral leukocytes were used for the analysis.
    [Frontiers in Immunology]

    Full Article

    TAp63α
    Targeting of Lgr5 Mediates Colorectal Cancer Stem Cell Properties and Sulforaphane Inhibition

    Scientists investigated the role of TAp63α in colorectal cancer stem cells and the effects of sulforaphane on TAp63α. They found that TAp63α was upregulated in spheres with stem cell properties compared to the parental cells.
    [Oncogenesis]

    Full Article

    Tideglusib
    Attenuates Growth of Neuroblastoma Cancer Stem/Progenitor Cells In Vitro and In Vivo by Specifically Targeting GSK-3β

    Investigators evaluated the potential anti-tumor effect of Tideglusib, an irreversible glycogen synthase kinase (GSK-3β) inhibitor drug, on three human neuroblastoma cell lines, SK-N-SH, SH-SY5Y, and IMR-32.
    [Pharmacological Reports]

    Abstract


    How have LSCs changed our understanding of myeloid malignancies? Webinar by Dr. Christopher Park, NYU
    REVIEWS

    Transitional
    Dynamics of Cancer Stem Cells in Invasion and Metastasis

    The authors advocate with substantial evidence the dynamic model of tumor propagation by exploring the specific cell types, reversible phenotypic plasticity between the tumorigenic leader seeds and the supporting follower cancer cells both in circulation and in solid tissue to accurately decipher tumor promoting clones and its role in metastatic dissemination and tumor re-growth.
    [Translational Oncology]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    WindMIL Therapeutics and Stephenson Cancer Center Announce Collaboration to Collect Bone Marrow from Patients with Renal and Urothelial Carcinomas to Develop Marrow Infiltrating Lymphocytes

    WindMIL Therapeutics (WindMIL) and Stephenson Cancer Center announced that the first patients have been identified in an investigator-sponsored study for the collection of bone marrow from patients with renal and urothelial carcinomas. The study will evaluate generating marrow infiltrating lymphocytes for these patients through WindMIL’s proprietary cellular activation and expansion process.
    [WindMIL Therapeutics (Globe Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    Keystone
    Symposia: Tumor Metabolism and the Microenvironment

    January 25 – January 28, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Clinical
    Research Associate – Hematology, Oncology, and Bone Marrow Transplantation

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral
    Scientists – Stem Cell Factors in Epithelial Cancers

    The University of Chicago – Chicago, Illinois, United States

    Research Fellow – Pancreatic and Liver Cancers

    The Mayo Clinic – Jacksonville, Florida, United States

    Assistant/Associate
    Professor – Center for Molecular Medicine

    The University of Georgia – Athens, Georgia, United States

    Postdoctoral Position – Human Pluripotent Stem Cells, Hematopoiesis and Leukemia

    Icahn School of Medicine at Mount Sinai – New York City, New York, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Science News Cancer Stem Cell News
    Archives Contact Us
    Cancer Stem Cell News Twitter