Cancer Stem Cell News Volume 9.39 | Oct 14 2020







2020-10-14 | CSCN 9.39


Cancer Stem Cell News by STEMCELL Technologies
Vol. 9.39 – 14 October, 2020
TOP STORY

Jagged1-Notch1-Deployed
Tumor Perivascular Niche Promotes Breast Cancer Stem Cell Phenotype through Zeb1

Scientists demonstrated that, with direct cell-cell contact, tumor microenvironment-derived endothelial cells provided the Notch ligand Jagged1 to neighboring breast cancer stem cells, leading to Notch1-dependent upregulation of Zeb1.
[Nature Communications]

Full Article


Bruno Silva-Santos shares his work on understanding the role of gamma delta T cells in cancer immunity. Watch the webinar.
PUBLICATIONSRanked by the impact factor of the journal

Prominin-1-Radixin
Axis Controls Hepatic Gluconeogenesis by Regulating PKA Activity

Investigators analyzed the levels of mRNA transcripts in serum‐starved primary WT and KO mouse hepatocytes using RNA sequencing data, and found that cyclic AMP response element‐binding protein target genes were downregulated.
[EMBO Journal]

AbstractGraphical Abstract

Immune
Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection

Extracellular matrix-rich tumors exhibited a stem cell-like gene expression profile and superior tumor-initiating capacity, whereas such features were absent in responder tumors.
[Cancer Immunology Research]

AbstractFull Article

SIRT1-Mediated
Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness

Investigators report that NAD-dependent deacetylase sirtuin-1 (SIRT1) signaling regulated colorectal cancer (CRC) stemness by enhancing expression of CD24, a CRC stemness promoter.
[Cancer Research]

Abstract

SUV39H1 Regulates the Progression of MLL-AF9-Induced Acute Myeloid Leukemia

Scientists found that SUV39H1 was down-regulated in a variety of leukemias, including MLL-r AML, as compared with normal individuals.
[Oncogene]

Full Article

Megalencephalic
Leukoencephalopathy with Subcortical Cysts 1 (MLC1) Promotes Glioblastoma Cell Invasion in the Brain Microenvironment

The authors showed that Mlc1 was expressed in human stem-like glioblastoma (GBM) cells and was linked to the development of primary and recurrent GBM.
[Oncogene]

Abstract

RASSF1A
Inhibits PDGFB-Driven Malignant Phenotypes of Nasopharyngeal Carcinoma Cells in a YAP1-Dependent Manner

Researchers observed that ras-association domain family protein1 isoform A (RASSF1A) expression inhibited the malignant phenotypes of nasopharyngeal carcinoma (NPC) cells. Stable silencing of RASSF1A in NPC cell lines induced self-renewal properties and tumorigenicity in vivo/in vitro and the acquisition of an invasive phenotype in vitro.
[Cell Death & Disease]

Full Article

Single-Cell
RNA-Sequencing Shift in the Interaction Pattern between Glioma Stem Cells and Immune Cells during Tumorigenesis

Single-cell sequencing data from seven surgical specimens of glioblastoma patients and patient-derived glioma stem cells co-cultured with peripheral leukocytes were used for the analysis.
[Frontiers in Immunology]

Full Article

TAp63α
Targeting of Lgr5 Mediates Colorectal Cancer Stem Cell Properties and Sulforaphane Inhibition

Scientists investigated the role of TAp63α in colorectal cancer stem cells and the effects of sulforaphane on TAp63α. They found that TAp63α was upregulated in spheres with stem cell properties compared to the parental cells.
[Oncogenesis]

Full Article

Tideglusib
Attenuates Growth of Neuroblastoma Cancer Stem/Progenitor Cells In Vitro and In Vivo by Specifically Targeting GSK-3β

Investigators evaluated the potential anti-tumor effect of Tideglusib, an irreversible glycogen synthase kinase (GSK-3β) inhibitor drug, on three human neuroblastoma cell lines, SK-N-SH, SH-SY5Y, and IMR-32.
[Pharmacological Reports]

Abstract


How have LSCs changed our understanding of myeloid malignancies? Webinar by Dr. Christopher Park, NYU
REVIEWS

Transitional
Dynamics of Cancer Stem Cells in Invasion and Metastasis

The authors advocate with substantial evidence the dynamic model of tumor propagation by exploring the specific cell types, reversible phenotypic plasticity between the tumorigenic leader seeds and the supporting follower cancer cells both in circulation and in solid tissue to accurately decipher tumor promoting clones and its role in metastatic dissemination and tumor re-growth.
[Translational Oncology]

AbstractGraphical Abstract
INDUSTRY AND POLICY NEWS

WindMIL Therapeutics and Stephenson Cancer Center Announce Collaboration to Collect Bone Marrow from Patients with Renal and Urothelial Carcinomas to Develop Marrow Infiltrating Lymphocytes

WindMIL Therapeutics (WindMIL) and Stephenson Cancer Center announced that the first patients have been identified in an investigator-sponsored study for the collection of bone marrow from patients with renal and urothelial carcinomas. The study will evaluate generating marrow infiltrating lymphocytes for these patients through WindMIL’s proprietary cellular activation and expansion process.
[WindMIL Therapeutics (Globe Newswire, Inc.)]

Press Release

FEATURED EVENT

Keystone
Symposia: Tumor Metabolism and the Microenvironment

January 25 – January 28, 2021
Virtual


> See All Events

JOB OPPORTUNITIES

Clinical
Research Associate – Hematology, Oncology, and Bone Marrow Transplantation

The University of British Columbia – Vancouver, British Columbia, Canada

Postdoctoral
Scientists – Stem Cell Factors in Epithelial Cancers

The University of Chicago – Chicago, Illinois, United States

Research Fellow – Pancreatic and Liver Cancers

The Mayo Clinic – Jacksonville, Florida, United States

Assistant/Associate
Professor – Center for Molecular Medicine

The University of Georgia – Athens, Georgia, United States

Postdoctoral Position – Human Pluripotent Stem Cells, Hematopoiesis and Leukemia

Icahn School of Medicine at Mount Sinai – New York City, New York, United States

> See All Jobs

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