 | | Vol. 9.41 – 28 October, 2020 |
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| Scientists demonstrated that resistance to venetoclax with azacitidine occurs via upregulation of fatty acid oxidation, which occurs either due to RAS pathway mutations or as a compensatory adaptation in relapsed disease.
[Nature Cancer] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors report that the cerebrospinal fluid circulating tumor DNA recapitulated the genomic alterations of the tumor and facilitated subgrouping and risk stratification, providing valuable information about diagnosis and prognosis.
[Nature Communications] |
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| To target acute myeloid leukemia blasts and leukemic stem cells using natural killer (NK) cells, researchers developed a trispecific killer engager molecule containing a humanized anti-CD16 heavy chain camelid single-domain antibody that activates NK cells.
[Leukemia] |
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| Scientists investigated the role of distinct subtypes of pancreatic CSCs and their metabolomic signatures in organ-specific metastatic colonization.
[Oncogene] |
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| CSCs were isolated from human colon cancer cell lines, where the stemness of the cells was evaluated by cell viability, colony-forming, spheroid-forming, invasion, migration, and apoptosis assays.
[Journal of Experimental & Clinical Cancer Research] |
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| In vitro and in vivo experiments confirmed BCL11B as a tumor suppressor in hepatocellular carcinoma with inhibitory effects on proliferation, cell cycle progression, apoptosis, and mobility.
[Cell Death & Disease] |
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| Investigators observed that Lin28B was up‐regulated in pancreatic cancer, contributing to cellular migration and proliferation. Nuclear Lin28B upregulated TET3 mRNA and protein levels by blocking the production of mature let‐7i.
[Molecular Oncology] |
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| In vitro infection of the T24 cell line with E. coli was performed to study the bacterial impact on bladder cancer cells. EMT markers were assessed using immunohistochemistry, western blot and RT-PCR. Stemness characteristics were monitored using RT-PCR.
[Scientific Reports] |
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| Using time-lapse imaging of mouse mammary tumor organoids in 3D culture, researchers observed that outgrowth potential varied non-linearly with initial organoid size.
[Journal of Mammary Gland Biology and Neoplasia] |
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| The authors detail the metabolic features of leukemic stem cells (LSCs) and how these characteristics promote resistance to traditional chemotherapy. They also discuss new therapeutic approaches that target metabolic vulnerabilities of LSC to selectively eradicate them.
[Trends in Molecular Medicine] |
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| Investigators focus on the contribution of chromosome instability studies to genetic heterogeneity in circulating tumor cells (CTCs) at the single-CTC level by discussing data from different cancer subtypes and their impact on diagnosis and precision medicine.
[Cancers] |
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| NexImmune announced that it has signed a research initiative related to its AIM nanoparticle technology with City of Hope, a world-renowned independent research and treatment center for cancer, diabetes and other life-threatening diseases.
[NexImmune] |
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| Keros Therapeutics, Inc. announced that it has dosed the first two participants in a Phase II clinical trial evaluating KER-050 for the treatment of anemia and thrombocytopenia in MDS.
[Keros Therapeutics, Inc.] |
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| Sumitomo Dainippon Pharma Oncology, Inc. announced the first patient has been dosed in a Phase Ib/II study evaluating the oral investigational agent, dubermatinib, an AXL kinase inhibitor, in combination with decitabine, in patients 60 years or older with newly diagnosed acute myeloid leukemia who have TP53 mutations and/or complex karyotype.
[Sumitomo Dainippon Pharma Oncology, Inc.] |
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| January 9 – January 12, 2021
Lake Buena Vista, Florida, United States |
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| | IRCCS Candiolo Cancer Institute – Candiolo, Italy |
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| | Karolinska Institutet – Flemingsberg, Sweden |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | The University of Chicago – Chicago, Illinois, United States |
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| | The University of Georgia – Athens, Georgia, United States |
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