Cancer Stem Cell News Volume 9.41 | Oct 28 2020

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    2020-10-28 | Oct 2020


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 9.41 – 28 October, 2020
    TOP STORY

    Fatty Acid Metabolism Underlies Venetoclax Resistance in Acute Myeloid Leukemia Stem Cells

    Scientists demonstrated that resistance to venetoclax with azacitidine occurs via upregulation of fatty acid oxidation, which occurs either due to RAS pathway mutations or as a compensatory adaptation in relapsed disease.
    [Nature Cancer]

    Full Article

    How can evaluating the immuno-oncology potential of compounds in vitro predict clinical outcomes? Watch this webinar by Dr. Alison O'Mahony, Eurofins DiscoverX
    PUBLICATIONSRanked by the impact factor of the journal

    Circulating Tumor DNA from the Cerebrospinal Fluid Allows the Characterisation and Monitoring of Medulloblastoma

    The authors report that the cerebrospinal fluid circulating tumor DNA recapitulated the genomic alterations of the tumor and facilitated subgrouping and risk stratification, providing valuable information about diagnosis and prognosis.
    [Nature Communications]

    Full Article

    A Trispecific Killer Engager Molecule Against CLEC12A Effectively Induces NK-Cell Mediated Killing of AML Cells

    To target acute myeloid leukemia blasts and leukemic stem cells using natural killer (NK) cells, researchers developed a trispecific killer engager molecule containing a humanized anti-CD16 heavy chain camelid single-domain antibody that activates NK cells.
    [Leukemia]

    Full Article

    Metabolic Programming of Distinct Cancer Stem Cells Promotes Metastasis of Pancreatic Ductal Adenocarcinoma

    Scientists investigated the role of distinct subtypes of pancreatic CSCs and their metabolomic signatures in organ-specific metastatic colonization.
    [Oncogene]

    Abstract

    NF-κB Maintains the Stemness of Colon Cancer Cells by Downregulating miR-195-5p/497–5p and Upregulating MCM2

    CSCs were isolated from human colon cancer cell lines, where the stemness of the cells was evaluated by cell viability, colony-forming, spheroid-forming, invasion, migration, and apoptosis assays.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    BCL11B Suppresses Tumor Progression and Stem Cell Traits in Hepatocellular Carcinoma by Restoring p53 Signaling Activity

    In vitro and in vivo experiments confirmed BCL11B as a tumor suppressor in hepatocellular carcinoma with inhibitory effects on proliferation, cell cycle progression, apoptosis, and mobility.
    [Cell Death & Disease]

    Full Article

    The KRAS/Lin28B Axis Maintains Stemness of Pancreatic Cancer Cells via the Let-7i/TET3 Pathway

    Investigators observed that Lin28B was up‐regulated in pancreatic cancer, contributing to cellular migration and proliferation. Nuclear Lin28B upregulated TET3 mRNA and protein levels by blocking the production of mature let‐7i.
    [Molecular Oncology]

    AbstractFull Article

    Escherichia coli Foster Bladder Cancer Cell Line Progression via Epithelial Mesenchymal Transition, Stemness and Metabolic Reprogramming

    In vitro infection of the T24 cell line with E. coli was performed to study the bacterial impact on bladder cancer cells. EMT markers were assessed using immunohistochemistry, western blot and RT-PCR. Stemness characteristics were monitored using RT-PCR.
    [Scientific Reports]

    Full Article

    Optimal, Large-Scale Propagation of Mouse Mammary Tumor Organoids

    Using time-lapse imaging of mouse mammary tumor organoids in 3D culture, researchers observed that outgrowth potential varied non-linearly with initial organoid size.
    [Journal of Mammary Gland Biology and Neoplasia]

    Full Article

    Survey Report: Where Is Pluripotent Stem Cell Research Now?
    REVIEWS

    Extinguishing the Embers: Targeting AML Metabolism

    The authors detail the metabolic features of leukemic stem cells (LSCs) and how these characteristics promote resistance to traditional chemotherapy. They also discuss new therapeutic approaches that target metabolic vulnerabilities of LSC to selectively eradicate them.
    [Trends in Molecular Medicine]

    Abstract

    Genomic Instability in Circulating Tumor Cells

    Investigators focus on the contribution of chromosome instability studies to genetic heterogeneity in circulating tumor cells (CTCs) at the single-CTC level by discussing data from different cancer subtypes and their impact on diagnosis and precision medicine.
    [Cancers]

    Full Article

    INDUSTRY AND POLICY NEWS

    NexImmune Establishes Research Initiative with City of Hope to Focus on Novel Immunotherapeutic Approaches to Acute Myeloid Leukemia

    NexImmune announced that it has signed a research initiative related to its AIM nanoparticle technology with City of Hope, a world-renowned independent research and treatment center for cancer, diabetes and other life-threatening diseases.
    [NexImmune]

    Press Release

    Keros Therapeutics, Inc. Announces Dosing of First Participants in Phase II Clinical Trial of KER-050 in Myelodysplastic Syndromes (MDS)

    Keros Therapeutics, Inc. announced that it has dosed the first two participants in a Phase II clinical trial evaluating KER-050 for the treatment of anemia and thrombocytopenia in MDS.
    [Keros Therapeutics, Inc.]

    Press Release

    Sumitomo Dainippon Pharma Oncology Announces First Patient Dosed in the Dubermatinib Arm of The Leukemia & Lymphoma Society’s Beat AML Master Clinical Trial in Patients with Acute Myeloid Leukemia

    Sumitomo Dainippon Pharma Oncology, Inc. announced the first patient has been dosed in a Phase Ib/II study evaluating the oral investigational agent, dubermatinib, an AXL kinase inhibitor, in combination with decitabine, in patients 60 years or older with newly diagnosed acute myeloid leukemia who have TP53 mutations and/or complex karyotype.
    [Sumitomo Dainippon Pharma Oncology, Inc.]

    Press Release
    FEATURED EVENT

    The Evolving Tumor Microenvironment In Cancer Progression: Mechanisms and Emerging Therapeutic Opportunities

    January 9 – January 12, 2021
    Lake Buena Vista, Florida, United States

    > See All Events

    JOB OPPORTUNITIES

    Senior Group Leader – Rare Cancers

    IRCCS Candiolo Cancer Institute – Candiolo, Italy

    Senior Researcher – Translational Medicine and Therapeutics for Leukemia

    Karolinska Institutet – Flemingsberg, Sweden

    Clinical Research Associate – Hematology, Oncology, and Bone Marrow Transplantation

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Scientists – Stem Cell Factors in Epithelial Cancers

    The University of Chicago – Chicago, Illinois, United States

    Assistant/Associate Professor – Center for Molecular Medicine

    The University of Georgia – Athens, Georgia, United States

    > See All Jobs

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