Cancer Stem Cell News Volume 9.42 | Nov 4 2020







2020-11-04 | CSCN 9.42


Cancer Stem Cell News by STEMCELL Technologies
Vol. 9.42 – 4 November, 2020
TOP STORY

SATB2
Drives Glioblastoma Growth by Recruiting CBP to Promote FOXM1 Expression in Glioma Stem Cells

Researchers showed that the Special AT‐rich Binding Protein‐2 (SATB2), one of the crucial nuclear matrix‐associated proteins, recruited histone acetyltransferase CBP to promote the FOXM1‐mediated cell proliferation and tumor growth of glioblastoma.
[EMBO Molecular Medicine]

Full ArticleGraphical Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Secretory
Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness

High-throughput RNA-sequencing analysis from pancreatic tissues of KCM animals revealed a significant decrease in cancer stem cell markers Aldh1a1, Klf4, EpCAM, and CD133.
[Cancer Research]

Abstract

Insulin
Receptor Substrate-1 (IRS-1) Mediates Progesterone Receptor-Driven Stemness and Endocrine Resistance in Oestrogen Receptor+ Breast Cancer

The transcriptomes of primary tumors and metastases in mice harboring estrogen receptor+ breast cancer patient-derived xenografts were analyzed following single-cell RNAseq. In vitro assays were employed to delineate mechanisms of endocrine resistance and stemness.
[British Journal of Cancer]

AbstractGraphical Abstract

LncRNA
LHFPL3-AS1 Contributes to Tumorigenesis of Melanoma Stem Cells via the miR-181a-5p/BCL2 Pathway

The authors revealed that the lncRNA LHFPL3-AS1-long, generated from the polypyrimidine tract binding protein 1-mediated splicing of the LHFPL3-AS1 precursor, upregulated B-cell lymphoma-2 (BCL2) protein to contribute to tumorigenesis of melanoma stem cells.
[Cell Death & Disease]

Full Article

Circulating
Tumor DNA (ctDNA) Detection Is Associated with Shorter Progression-Free Survival in Advanced Melanoma Patients

Investigators proposed to standardize a liquid biopsy platform to identify hotspot mutations in BRAF, NRAS and TERT in plasma samples from advanced melanoma patients and investigated whether it was associated to clinical outcome.
[Scientific Reports]

Full Article

The
HIF1α/JMY Pathway Promotes Glioblastoma Stem-Like Cell Invasiveness after Irradiation

Scientists showed that ionizing radiation specifically enhanced the motility and invasiveness of human glioma stem cells through the stabilization and nuclear accumulation of the hypoxia-inducible factor 1α (HIF1α), which in turn transcriptionally activated the Junction-mediating and regulatory protein.
[Scientific Reports]

Full Article

Differential
Sensitivities of Triple-Negative Breast Cancer Stem Cell towards Various Doses of Vitamin C: An Insight into the Internal Antioxidant Systems

The authors investigated the cellular energetics of two triple‐negative breast cancer stem cells treated with two pharmacological doses of vitamin C that generated reactive oxygen species.
[Journal of Cellular Biochemistry]

Abstract

The
Potential Use of Tideglusib as an Adjuvant Radio-Therapeutic Treatment for Glioblastoma Multiforme Cancer Stem-Like Cells

Treatment with Tideglusib alone and in combination with radiation significantly decreased the colony formation of U-251 MG cells and the sphere formation of both cell lines, by targeting and reducing their glioblastoma cancer stem-like cell population.
[Pharmacological Reports]

Abstract

Knockdown
of STIP1 Inhibits the Invasion of CD133-Positive Cancer Stem-Like Cells of the Osteosarcoma MG63 Cell Line via the PI3K/Akt and ERK1/2 Pathways

CD133‑positive osteosarcoma CSCs were first isolated and cultured by magnetic cell sorting and serum‑free medium suspension cell sphere culture, respectively.
[International Journal of Molecular Medicine]

Abstract


Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
REVIEWS

Breast
Cancers, Mammary Stem Cells, and Cancer Stem Cells, Characteristics, and Hypotheses

Two models have been proposed to explain the cell of origin of breast cancer and involve either the reprogramming of differentiated mammary cells or the dysregulation of mammary stem cells or progenitors. Both hypotheses are not exclusive and imply the accumulation of independent mutational events.
[Neoplasia]

Full Article

INDUSTRY AND POLICY NEWS

Astex Pharmaceuticals Expands Clinical Evaluation of Oral Decitabine and Cedazuridine Tablets through New Cooperative Research and Development Agreement (CRADA) with the US National Cancer Institute

Astex Pharmaceuticals, Inc. announced it has entered into a Cooperative Research and Development Agreement with the US National Cancer Institute, part of National Institutes of Health. The agreement calls for a range of new clinical and translational studies of oral decitabine and cedazuridine tablets as an anticancer agent to be conducted in collaboration with Astex.
[Astex Pharmaceuticals, Inc.]

Press Release

AIVITA Biomedical Completes Treatment of Patients in Phase II Clinical Trial of Glioblastoma Immunotherapy

AIVITA Biomedical, Inc. announced that treatment has been completed for all 57 patients in the Phase II clinical trial of AV-GBM-1 in patients with glioblastoma. The company was able to manufacture final product at a notable 94% success rate, showing strong commercial and clinical viability.
[AIVITA Biomedical, Inc.]

Press Release

FEATURED EVENT

Keystone
Symposia: Single Cell Biology

March 17 – March 19, 2021
Virtual


> See All Events

JOB OPPORTUNITIES

Research Faculty Positions – Melanoma

Duke University – Durham, North Carolina, United States

Senior Group Leader – Rare Cancers

IRCCS Candiolo Cancer Institute – Candiolo, Italy

Senior Researcher – Translational Medicine and Therapeutics for Leukemia

Karolinska Institutet – Flemingsberg, Sweden

Clinical
Research Associate – Hematology, Oncology, and Bone Marrow Transplantation

The University of British Columbia – Vancouver, British Columbia, Canada

Postdoctoral
Scientists – Stem Cell Factors in Epithelial Cancers

The University of Chicago – Chicago, Illinois, United States

> See All Jobs

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