Cancer Stem Cell News Volume 9.42 | Nov 4 2020

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    2020-11-04 | CSCN 9.42


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 9.42 – 4 November, 2020
    TOP STORY

    SATB2
    Drives Glioblastoma Growth by Recruiting CBP to Promote FOXM1 Expression in Glioma Stem Cells

    Researchers showed that the Special AT‐rich Binding Protein‐2 (SATB2), one of the crucial nuclear matrix‐associated proteins, recruited histone acetyltransferase CBP to promote the FOXM1‐mediated cell proliferation and tumor growth of glioblastoma.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Secretory
    Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness

    High-throughput RNA-sequencing analysis from pancreatic tissues of KCM animals revealed a significant decrease in cancer stem cell markers Aldh1a1, Klf4, EpCAM, and CD133.
    [Cancer Research]

    Abstract

    Insulin
    Receptor Substrate-1 (IRS-1) Mediates Progesterone Receptor-Driven Stemness and Endocrine Resistance in Oestrogen Receptor+ Breast Cancer

    The transcriptomes of primary tumors and metastases in mice harboring estrogen receptor+ breast cancer patient-derived xenografts were analyzed following single-cell RNAseq. In vitro assays were employed to delineate mechanisms of endocrine resistance and stemness.
    [British Journal of Cancer]

    AbstractGraphical Abstract

    LncRNA
    LHFPL3-AS1 Contributes to Tumorigenesis of Melanoma Stem Cells via the miR-181a-5p/BCL2 Pathway

    The authors revealed that the lncRNA LHFPL3-AS1-long, generated from the polypyrimidine tract binding protein 1-mediated splicing of the LHFPL3-AS1 precursor, upregulated B-cell lymphoma-2 (BCL2) protein to contribute to tumorigenesis of melanoma stem cells.
    [Cell Death & Disease]

    Full Article

    Circulating
    Tumor DNA (ctDNA) Detection Is Associated with Shorter Progression-Free Survival in Advanced Melanoma Patients

    Investigators proposed to standardize a liquid biopsy platform to identify hotspot mutations in BRAF, NRAS and TERT in plasma samples from advanced melanoma patients and investigated whether it was associated to clinical outcome.
    [Scientific Reports]

    Full Article

    The
    HIF1α/JMY Pathway Promotes Glioblastoma Stem-Like Cell Invasiveness after Irradiation

    Scientists showed that ionizing radiation specifically enhanced the motility and invasiveness of human glioma stem cells through the stabilization and nuclear accumulation of the hypoxia-inducible factor 1α (HIF1α), which in turn transcriptionally activated the Junction-mediating and regulatory protein.
    [Scientific Reports]

    Full Article

    Differential
    Sensitivities of Triple-Negative Breast Cancer Stem Cell towards Various Doses of Vitamin C: An Insight into the Internal Antioxidant Systems

    The authors investigated the cellular energetics of two triple‐negative breast cancer stem cells treated with two pharmacological doses of vitamin C that generated reactive oxygen species.
    [Journal of Cellular Biochemistry]

    Abstract

    The
    Potential Use of Tideglusib as an Adjuvant Radio-Therapeutic Treatment for Glioblastoma Multiforme Cancer Stem-Like Cells

    Treatment with Tideglusib alone and in combination with radiation significantly decreased the colony formation of U-251 MG cells and the sphere formation of both cell lines, by targeting and reducing their glioblastoma cancer stem-like cell population.
    [Pharmacological Reports]

    Abstract

    Knockdown
    of STIP1 Inhibits the Invasion of CD133-Positive Cancer Stem-Like Cells of the Osteosarcoma MG63 Cell Line via the PI3K/Akt and ERK1/2 Pathways

    CD133‑positive osteosarcoma CSCs were first isolated and cultured by magnetic cell sorting and serum‑free medium suspension cell sphere culture, respectively.
    [International Journal of Molecular Medicine]

    Abstract


    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    REVIEWS

    Breast
    Cancers, Mammary Stem Cells, and Cancer Stem Cells, Characteristics, and Hypotheses

    Two models have been proposed to explain the cell of origin of breast cancer and involve either the reprogramming of differentiated mammary cells or the dysregulation of mammary stem cells or progenitors. Both hypotheses are not exclusive and imply the accumulation of independent mutational events.
    [Neoplasia]

    Full Article

    INDUSTRY AND POLICY NEWS

    Astex Pharmaceuticals Expands Clinical Evaluation of Oral Decitabine and Cedazuridine Tablets through New Cooperative Research and Development Agreement (CRADA) with the US National Cancer Institute

    Astex Pharmaceuticals, Inc. announced it has entered into a Cooperative Research and Development Agreement with the US National Cancer Institute, part of National Institutes of Health. The agreement calls for a range of new clinical and translational studies of oral decitabine and cedazuridine tablets as an anticancer agent to be conducted in collaboration with Astex.
    [Astex Pharmaceuticals, Inc.]

    Press Release

    AIVITA Biomedical Completes Treatment of Patients in Phase II Clinical Trial of Glioblastoma Immunotherapy

    AIVITA Biomedical, Inc. announced that treatment has been completed for all 57 patients in the Phase II clinical trial of AV-GBM-1 in patients with glioblastoma. The company was able to manufacture final product at a notable 94% success rate, showing strong commercial and clinical viability.
    [AIVITA Biomedical, Inc.]

    Press Release

    FEATURED EVENT

    Keystone
    Symposia: Single Cell Biology

    March 17 – March 19, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Research Faculty Positions – Melanoma

    Duke University – Durham, North Carolina, United States

    Senior Group Leader – Rare Cancers

    IRCCS Candiolo Cancer Institute – Candiolo, Italy

    Senior Researcher – Translational Medicine and Therapeutics for Leukemia

    Karolinska Institutet – Flemingsberg, Sweden

    Clinical
    Research Associate – Hematology, Oncology, and Bone Marrow Transplantation

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral
    Scientists – Stem Cell Factors in Epithelial Cancers

    The University of Chicago – Chicago, Illinois, United States

    > See All Jobs

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