 | | Vol. 9.47 – 16 December, 2020 |
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| Using mouse models of skin squamous cell carcinoma and lung tumors, investigators found that deletion of Fat1 accelerated tumor initiation and malignant progression and promoted a hybrid epithelial-to-mesenchymal transition (EMT) phenotype.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists examined the combined and separate effects of an oncogene and exposure to interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and stem cell factor on the experimental genesis of a human acute myeloid leukemia in xenografted immunodeficient mice.
[Blood] |
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| The authors showed that ATP levels were markedly increased in the bone marrow niches of mice with acute myeloid leukemia, and leukemia-initiating cells preferred to localizing to the endosteal niche with relatively high ATP levels, as indicated by a sensitive ATP indicator.
[Journal of Clinical Investigation] |
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| Scientists found that cultured circulating tumor cells, derived from blood samples of women with advanced breast cancer and directly inoculated into the mouse frontal lobe, exhibited striking differences in proliferative potential in the brain.
[Nature Communications] |
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| Glioblastoma cells that are part of the tumor microtube-connected tumor network showed activated neurodevelopmental and glioma progression gene expression pathways. Importantly, many of them revealed profiles indicative of increased cellular stemness, including high expression of nestin.
[Neuro-Oncology] |
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| Loss and gain of function studies revealed that FZD5 contributed to triple negative breast cancer cell G1/S transition, DNA replication, DNA damage repair, survival, and stemness. Mechanistically, transcription factor FOXM1, which promoted BRCA1 and BIRC5 transcription, acted as a downstream effecter of FZD5 signaling.
[Cell Death & Disease] |
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| Researchers demonstrated that zinc-finger MYND type-8 (ZMYND8), a putative chromatin reader, suppressed stemness, drug resistance, and tumor-promoting genes, which are hallmarks of cancer.
[Cell Death & Disease] |
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| Systemic application of miRDRELs to natural oncomiR targets, knockdown of key microprocessors, and physiological triggering of oncomiRs demonstrated that a lentivirus-based system was an effective tool for monitoring cellular oncomiR action.
[Experimental and Molecular Medicine] |
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| The authors utilized glioblastoma neurospheres that display glioblastoma stem cells characteristics and found activation of the PI3K/AKT pathway in sphere-forming cells. The PI3Kα selective inhibitor alpelisib blocked PI3K/AKT activation and inhibited spheroid growth, suggesting an essential role for the PI3Kα catalytic isoform.
[Scientific Reports] |
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| Investigators characterized the aberrant upregulation of CDK11B and downregulation SAM pointed domain-containing ETS transcription factor (SPDEF) in hepatocellular carcinoma tissues and cells.
[Cancer Gene Therapy] |
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| Notch signaling is involved in many aspects of cancer biology, including angiogenesis, tumor immunity and the maintenance of cancer stem-like cells.
[Nature Reviews Drug Discovery] |
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| Novocure announced that the first patient has been enrolled in its global Phase III TRIDENT trial, a randomized study in newly diagnosed glioblastoma testing the potential survival benefit of initiating Optune® concurrent with radiation therapy.
[Novocure] |
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| January 7 – 8, 2021
Virtual |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Salk Institute of Biological Studies – La Jolla, California, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Peking University Shenzhen Graduate School – Shenzhen, China |
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