Cancer Stem Cell News Volume 9.47 | Dec 16 2020

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    2020-12-16 | CSCN 9.47


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 9.47 – 16 December, 2020
    TOP STORY

    Fat1 Deletion Promotes Hybrid EMT State, Tumor Stemness and Metastasis

    Using mouse models of skin squamous cell carcinoma and lung tumors, investigators found that deletion of Fat1 accelerated tumor initiation and malignant progression and promoted a hybrid epithelial-to-mesenchymal transition (EMT) phenotype.
    [Nature]

    Abstract

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    MYC-Induced Human Acute Myeloid Leukemia Requires a Continuing IL-3/GM-CSF Costimulus

    Scientists examined the combined and separate effects of an oncogene and exposure to interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and stem cell factor on the experimental genesis of a human acute myeloid leukemia in xenografted immunodeficient mice.
    [Blood]

    Abstract

    Bone
    Marrow Niche ATP Levels Determine Leukemia-Initiating Cell Activity via P2X7 in Leukemic Models

    The authors showed that ATP levels were markedly increased in the bone marrow niches of mice with acute myeloid leukemia, and leukemia-initiating cells preferred to localizing to the endosteal niche with relatively high ATP levels, as indicated by a sensitive ATP indicator.
    [Journal of Clinical Investigation]

    AbstractFull Article
    Graphical Abstract

    HIF1A Signaling Selectively Supports Proliferation of Breast Cancer in the Brain

    Scientists found that cultured circulating tumor cells, derived from blood samples of women with advanced breast cancer and directly inoculated into the mouse frontal lobe, exhibited striking differences in proliferative potential in the brain.
    [Nature Communications]

    Full Article

    Tumor
    Cell Network Integration in Glioma Represents a Stemness Feature

    Glioblastoma cells that are part of the tumor microtube-connected tumor network showed activated neurodevelopmental and glioma progression gene expression pathways. Importantly, many of them revealed profiles indicative of increased cellular stemness, including high expression of nestin.
    [Neuro-Oncology]

    Abstract

    FZD5 Contributes to TNBC Proliferation, DNA Damage Repair and Stemness

    Loss and gain of function studies revealed that FZD5 contributed to triple negative breast cancer cell G1/S transition, DNA replication, DNA damage repair, survival, and stemness. Mechanistically, transcription factor FOXM1, which promoted BRCA1 and BIRC5 transcription, acted as a downstream effecter of FZD5 signaling.
    [Cell Death & Disease]

    Full Article

    Suppression of Poised Oncogenes by ZMYND8 Promotes Chemo-Sensitization

    Researchers demonstrated that zinc-finger MYND type-8 (ZMYND8), a putative chromatin reader, suppressed stemness, drug resistance, and tumor-promoting genes, which are hallmarks of cancer.
    [Cell Death & Disease]

    Full Article

    Development
    of a miRNA-Controlled Dual-Sensing System and Its Application for Targeting miR-21 Signaling in Tumorigenesis

    Systemic application of miRDRELs to natural oncomiR targets, knockdown of key microprocessors, and physiological triggering of oncomiRs demonstrated that a lentivirus-based system was an effective tool for monitoring cellular oncomiR action.
    [Experimental and Molecular Medicine]

    Full Article

    Combined PI3Kα-mTOR Targeting of Glioma Stem Cells

    The authors utilized glioblastoma neurospheres that display glioblastoma stem cells characteristics and found activation of the PI3K/AKT pathway in sphere-forming cells. The PI3Kα selective inhibitor alpelisib blocked PI3K/AKT activation and inhibited spheroid growth, suggesting an essential role for the PI3Kα catalytic isoform.
    [Scientific Reports]

    Full Article

    Involvement
    of CDK11B-Mediated SPDEF Ubiquitination and SPDEF-Mediated MicroRNA-448 Activation in the Oncogenicity and Self-Renewal of Hepatocellular Carcinoma Stem Cells

    Investigators characterized the aberrant upregulation of CDK11B and downregulation SAM pointed domain-containing ETS transcription factor (SPDEF) in hepatocellular carcinoma tissues and cells.
    [Cancer Gene Therapy]

    Abstract

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    REVIEWS

    Targeting Notch in Oncology: The Path Forward

    Notch signaling is involved in many aspects of cancer biology, including angiogenesis, tumor immunity and the maintenance of cancer stem-like cells.
    [Nature Reviews Drug Discovery]

    Abstract
    INDUSTRY AND POLICY NEWS

    First Patient Enrolled in Novocure® Global Phase III TRIDENT Trial of Optune® Concurrent with Radiation Therapy in Newly Diagnosed Glioblastoma

    Novocure announced that the first patient has been enrolled in its global Phase III TRIDENT trial, a randomized study in newly diagnosed glioblastoma testing the potential survival benefit of initiating Optune® concurrent with radiation therapy.
    [Novocure]

    Press Release

    FEATURED EVENT

    ISSCR: Vision 2030 A Forecast for the Field

    January 7 – 8, 2021
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    JOB OPPORTUNITIES

    Research
    Assistant – Melanoma Medical Oncology

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Fellow – Breast Cancer Immuno-Oncology Research

    Salk Institute of Biological Studies – La Jolla, California, United States

    Faculty Position – Skin Cancer

    Columbia University Medical Center – New York, New York, United States

    Senior
    Investigator – Replication Stress and Chromatin Alterations

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Dean and Faculty Positions – Brain Cancer Biology

    Peking University Shenzhen Graduate School – Shenzhen, China

    > See All Jobs

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