Cell Therapy News 21.37 | Oct 26 2020

May 12, 2022

CTN 21.37 | Oct 26 2020

Cell Therapy News by STEMCELL Technologies

Vol. 21.37 – 26 October, 2020

TOP STORY

GD2-Specific
CAR T Cells Encapsulated in an Injectable Hydrogel Control Retinoblastoma and Preserve Vision

Investigators generated GD2-specific chimeric antigen receptor T lymphocytes and locally delivered them to mice with an in situ grafting retinoblastoma.
[Nature Cancer]

Abstract

Dr. Jackie Damen discusses why the CFU assay should be a vital part of your cell therapy workflow in this on-demand webinar.

PUBLICATIONSRanked by the impact factor of the journal

Regulatory
T Cells for Minimising Immune Suppression in Kidney Transplantation: Phase I/IIa Clinical Trial

The assessment included incidence of biopsy confirmed acute rejection, assessment of nTreg infusion related adverse effects, and signs of over immunosuppression.
[British Medical Journal]

Full Article

Generation
of Oligodendrocytes and Establishment of an All-Human Myelinating Platform from Human Pluripotent Stem Cells

Researchers describe a method to generate oligodendrocyte precursor cells from human pluripotent stem cells in only ~20 days, which could subsequently myelinate neurons, both in vitro and in vivo.
[Nature Protocols]

Abstract

Brainstem
Development Requires Galactosylceramidase and Is Critical for Pathogenesis in a Model of Krabbe Disease

Using a novel Galc floxed allele, investigators induced ubiquitous galactosylceramidase (GALC) ablation at various postnatal timepoints and identified a critical period of vulnerability to GALC ablation between P4-6 in mice.
[Nature Communications]

Full Article

Gene
Expression and Functional Deficits Underlie TREM2-Knockout Microglia Responses in Human Models of Alzheimer’s Disease

Scientists profiled microglia differentiated from isogenic, CRISPR-modified TREM2-knockout induced pluripotent stem cell lines.
[Nature Communications]

Full Article

Branched-Chain
Amino Acid Aminotransferase 2 Regulates Ferroptotic Cell Death in Cancer Cells

By using a high-throughput CRISPR/Cas9-based genetic screen in HepG2 hepatocellular carcinoma cells to search for metabolic proteins inhibiting ferroptosis, researchers identified a branched-chain amino acid aminotransferase 2 as a novel suppressor of ferroptosis.
[Cell Death & Differentiation]

Full Article

Abrogation
of HLA Surface Expression Using CRISPR/Cas9 Genome Editing: A Step Toward Universal T Cell Therapy

Host rejection driven by HLA disparity in adoptively transferred allogeneic T cells remains a key obstacle to the universal donor T cell therapy. To evade donor HLA-mediated immune rejection, scientists attempted to eliminate T cell’s HLA through the CRISPR/Cas9 gene editing system.
[Scientific Reports]

Full Article

Quantitative
PCR Methodology With a Volume-Based Unit for the Sophisticated Cellular Kinetic Evaluation of Chimeric Antigen Receptor T Cells

Researchers established a novel qPCR methodology incorporating a spike-in calibration curve that expressed cellular kinetics in units of copies/μL blood, as is the case for conventional pharmacokinetic studies of small molecules and other biologics.
[Scientific Reports]

Full Article

Mesenchymal
Stem Cells: a Potential Treatment Approach for Refractory Chronic Spontaneous Urticaria

Scientists found that the T cell subsets and inflammatory molecules were not affected by mesenchymal stem cell treatment during the follow-up period. In control patients, a significant decrease was detected only at the Th2 subset, TGF-β1, PGE2, IDO and anti-FcεRI levels on the 14th day of treatment.
[Stem Cell Reviews and Reports]

Abstract

CASZ1b Is a Novel Transcriptional Corepressor of Mineralocorticoid Receptor

Knockdown of CASZ1b via RNA interference increased the expression levels of the aldosterone-induced mineralocorticoid receptor target genes epithelial Na⁺ channel-α and serum/glucocorticoid regulated kinase 1 by approximately twofold and 2.3-fold.
[Hypertension Research]

Abstract

New human primary cell products—frozen leukopaks, regulatory T cells, and more. Click to view products.

REVIEWS

Gene
Therapy and Gene Correction: Targets, Progress, and Challenges for Treating Human Diseases

Gene correction using CRISPR-Cas9 is an extension of gene therapy that has received considerable attention in recent years and boasts many possible uses beyond classical gene therapy approaches.
[Gene Therapy]

Abstract

Human
Stem Cell-Derived Oligodendrocytes: From Humanized Animal Models to Cell Therapy in Myelin Diseases

The authors discuss the anatomical and functional benefit of grafted iPSC-progenitors over their brain counterparts, their use in disease modeling and the missing gaps that still prevent to study their biology in the most integrated way, and to translate iPSC-stem cell based therapy to the clinic.
[Seminars in Cell & Developmental Biology]

Abstract

INDUSTRY AND POLICY NEWS

Bayer
Acquires Asklepios BioPharmaceutical to Broaden Innovation Base in Cell and Gene Therapy

Bayer AG announced the acquisition of Asklepios BioPharmaceutical, Inc., a US-headquartered biopharmaceutical company specialized in the research, development and manufacturing of gene therapies across different therapeutic areas.
[Asklepios BioPharmaceutical]

Press Release

Global
Stem Cells Group Announces Partnership with Bioscience Cell Factory

Global Stem Cells Group (GSCG) has signed a historic agreement with a company known as Bioscience Cell Factor- this Dubai-based healthcare company will allow GSCG to act as their representatives operating in both the Middle East and Latin America.
[Global Stem Cells Group]

Press Release

FEATURED EVENT

GD2-Specific
CAR T Cells Encapsulated in an Injectable Hydrogel Control Retinoblastoma and Preserve Vision

Regulatory
T Cells for Minimising Immune Suppression in Kidney Transplantation: Phase I/IIa Clinical Trial

Generation
of Oligodendrocytes and Establishment of an All-Human Myelinating Platform from Human Pluripotent Stem Cells

Brainstem
Development Requires Galactosylceramidase and Is Critical for Pathogenesis in a Model of Krabbe Disease

Gene
Expression and Functional Deficits Underlie TREM2-Knockout Microglia Responses in Human Models of Alzheimer’s Disease

Branched-Chain
Amino Acid Aminotransferase 2 Regulates Ferroptotic Cell Death in Cancer Cells

Abrogation
of HLA Surface Expression Using CRISPR/Cas9 Genome Editing: A Step Toward Universal T Cell Therapy

Quantitative
PCR Methodology With a Volume-Based Unit for the Sophisticated Cellular Kinetic Evaluation of Chimeric Antigen Receptor T Cells

Mesenchymal
Stem Cells: a Potential Treatment Approach for Refractory Chronic Spontaneous Urticaria

CASZ1b Is a Novel Transcriptional Corepressor of Mineralocorticoid Receptor

Gene
Therapy and Gene Correction: Targets, Progress, and Challenges for Treating Human Diseases

Human
Stem Cell-Derived Oligodendrocytes: From Humanized Animal Models to Cell Therapy in Myelin Diseases

Bayer
Acquires Asklepios BioPharmaceutical to Broaden Innovation Base in Cell and Gene Therapy

Global
Stem Cells Group Announces Partnership with Bioscience Cell Factory

The American Association for Cancer Research (AACR) Annual Meeting 2021

> See All Events

Vice
President – Oncology and Cell Therapy

Postdoctoral Fellow – Cancer Immunology and Immunotherapy

Postdoctoral Researcher – Translational Neuroscience

Research
Fellow Position – Neural Cell Therapy

Research
Positions – Cancer and Immunotherapy

> See All Jobs