Cell Therapy News Volume 10.15 | Apr 27 2009

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    Justin.choi
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    Cell Therapy News 10.15, April 27, 2009
         In this issue: Science | Policy | Business | NIH | CBER | Regulatory
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    Top Stories

    Generating Safer, Therapeutic Stem Cells from Adult Cells: A group of researchers have achieved a breakthrough in converting adult cells all the way back to the most primitive embryonic-like cells without using any genes or genetic manipulations at all.
    Article

    Science

    Learn to Culture Neural Stem Cells with the Cell Experts(TM)

    STEMCELL Technologies is offering a 2-day Neural Stem Cell Training Course that provides hands-on instruction in the dissection, culture, identification and enumeration of neural stem and progenitor cells.

    May 22-23, 2009, Vancouver, Canada 

    Study Finds Blood Cells Can Be Reprogrammed to Act as Embryonic Stem Cells
    In a recent study, U.S. researchers have reprogrammed cells found in circulating blood into cells that are molecularly and functionally indistinguishable from embryonic stem cells.
    Article

    Blind to be Cured with Stem Cells
    British scientists have developed a treatment involving replacing a layer of degenerated cells with new ones created from embryonic stem cells.
    Article

    Cystic Fibrosis To Be Treated By Gene Therapy Technology
    Better treatment for cystic fibrosis by scientists involve plasmids, tiny circles of DNA that can carry healthy genes to where they can replace faulty CF genes in the lining of the lung.
    Article

    On the Trail of Huntington Disease
    Using gene therapy, University of Southern California Davis School of Gerontology researchers have taken an important first step toward protecting against Huntington disease.
    Article

    Magnetic Force to Ease Aching Bones
    Keele University researchers are testing injectable stem cells that they can control with a magnet, which would mean that doctors may soon be able to repair damaged bones and joints anywhere in the body with a simple injection.
    Article

    Human Stem Cells Promote Healing of Diabetic Ulcers
    Scientists in Bristol have found that human foetal stem cells can effectively be used to treat back leg ischaemic ulcers in a model of type 1 diabetes.
    Article

    New Method Developed by UC San Diego Bioengineers Gives Regenerative Medicine a Boost
    Bioengineers at UC San Diego have developed a breakthrough method for sequencing-based methylation profiling, which could help fuel personalized regenerative medicine and even lead to more efficient and cost-effective methods for studying certain diseases.
    Article

    University of British Columbia Research Finds Molecular “Key” to Successful Blood Stem Cell Transplants
    Canadian researchers have identified a molecule called S1P that can tell the thymus to “open the gates” and accept more stem cells.
    Article

    Stem Cells May Help Repair ACL Tears
    A novel approach to repairing partially torn anterior cruciate ligaments in young athletes has shown promise, according to a group of orthopedic surgeons in Italy.
    Article

    Osiris Completes Enrollment in Second Prochymal Phase III Trial for Graft vs. Host Disease
    Osiris Therapeutics, Inc. recently announced that it has successfully completed patient enrollment in its pivotal, Phase III trial evaluating Prochymal as a first-line treatment for acute graft vs. host disease.
    Article

    ABSTRACTS, REVIEWS AND SPECIAL REPORTS

    Efficient Production of Mesencephalic Dopamine Neurons by Lmx1a Expression in Embryonic Stem Cells
    This study shows that forced expression of Lmx1a, a transcription factor functioning as a determinant of mesDA neurons during embryogenesis, effectively can promote the generation of mesDA neurons from mouse and human ESCs.
    Article

    Effectiveness of Haemodialysis Access with an Autologous Tissue-engineered Vascular Graft: a Multicentre Cohort Study
    Application of a tissue-engineered vascular graft for small-diameter vascular reconstruction results after a minimum of 6 months of follow-up for the first ten patients implanted with a completely biological and autologous tissue-engineered vascular graft are reported.
    Article

    Dedifferentiated, Programmable Stem Cells of Monocytic Origin, and Their Production and Use
    The current patent covers the A process for the production of dedifferentiated, programmable cells of human monocytic origin.
    Article

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    Policy

    Judge Upholds Stem Cell Ballot Language
    A Cole County Circuit Court judge has dismissed parts of a lawsuit against Missouri Secretary of State Robin Carnahan and upheld ballot summary language for an initiative petition about prohibiting public money for certain abortion- or human cloning-related research and services.
    Article

    Money is Running Low at Maryland’s Venture Fund
    A state fund that invests in technology startups has recently put $450,000 into Maryland companies, but the future of the program is in flux because of a tight budget and sluggish market for investment returns.
    Article

    Maryland Stem Cell Research Commission: Public Meeting Notice
    Link

    Override Attempt Defeated: Senate Short 6 Votes on Stem Cell-ban Measure
    Governor Brad Henry’s veto of a measure that would have banned embryonic stem cell research withstood an override attempt Thursday in the state Legislature.
    Article

    UK’s Strategic Investment Fund Announces 750M Pound High-tech Fund
    The UK’s high-tech industrial sector will get an investment of 750 million pounds ($1.09 billion) through a fund focussing on advanced technology, the government said on Wednesday.
    Article

    Japan Lagging U.S. in iPS Cell Research
    Japan has been overtaken by the United States in terms of research into practical applications of induced pluripotent stem cells, first produced by Shinya Yamanaka of Kyoto University, for regenerative medicine.
    Article

    China Ramps Up Stem Cell Efforts Just Weeks After US Research U-Turn
    Construction of a new stem cell research and processing plant began recently in China’s Eastern Jiangsu province as part of a joint project between the Chinese government and Shenzen Beike Biotechnology.
    Article

    Business

    University College London–Pfizer to Develop Pioneering Stem Cell Sight Therapies
    UCL has entered into a collaboration with the biopharmaceutical group Pfizer to advance development of stem cell-based therapies for age-related macular degeneration.
    Article

    University of Utah Cell Therapy Lab Collaborates with Q Therapeutics on Stem Cell Therapy to Fight Lou Gehrig’s Disease
    With $5 million dollars in funding from the National Institutes of Health, the University of Utah’s Cell Therapy Facility and spin-out Q Therapeutics, Inc. have teamed up to bring the cell-based therapy to the point of human clinical trials to treat amyotrophic lateral sclerosis.
    Article

    Fate Therapeutics and Stemgent Launch Catalyst: A Unique Industry Program for First Access to the Most Advanced Induced Pluripotent Stem Cell Technology
    Fate Therapeutics, Inc. and Stemgent, Inc. announced recently the formation of Catalyst, a collaborative one-of-a-kind program to provide pharmaceutical and biotechnology companies with an induced pluripotent stem cell technology platform for drug discovery and development.
    Article

    Roche Madison Opens Facility in University Research Park
    The Madison subsidiary is focused in the areas of RNA interference and gene therapy, which plans to hire more employees during the next six to 12 months, has opened a new facility Thursday in University Research Park.
    Article

    Credit Crisis Puts Canadian Biotech at Risk
    The global credit crisis threatens to put many of Canada’s biotech companies out of business and choke off the country’s role in a key sector of the future economy, a study says.
    Article

    Alnylam Announces Allowance in Europe of New Fundamental Patent Broadly Covering RNAi Therapeutics
    Alnylam Pharmaceuticals announced recently that the European Patent Office has issued a notification of intent to grant for a patent in the Tuschl I patent series covering the use of double stranded RNAs for RNAi.
    Article

    NIH

    Draft National Institutes of Health Guidelines for Human Stem Cell Research
    Link

    Public Comment Period Open for Draft Stem Cell Guidelines through May 26, 2009 (NOT-OD-09-086)
    Link

    Error-Correction Window Extended for All Electronic Applications with Submission Deadlines through May 1, 2009 (NOT-OD-09-087)
    Link

    Translation and/or Commercialization of Musculoskeletal and Skin Tissue Engineering and Regenerative Medicine Research SBIR [R43/R44] (RFA-AR-10-004)
    Link

    National Cancer Institute’s Plan to Accelerate Cancer Research Announced
    The National Cancer Institute recently announced major details, such as funding more grants, development of a platform for personalized cancer care, and an accelerated cancer genetics program, that will move cancer research forward in this new economic environment.
    Article

    CBER

    Fast Track Designation Performance Report – Update
    Link

    Regulatory

    FOOD AND DRUG ADMINISTRATION (United States)

    Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Financial Disclosure by Clinical Investigators
    Link

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