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Stem Cell Hierarchy Offers Potential for Isolating, Growing Cells
The research from their paper finally provides the experimental proof of the existence of a human MSC at the single cell level, a key step that has previously eluded the scientific community. [University of Toronto Institute of Biomaterials and Biomedical Engineering, Toronto]
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Scientists Find Way to Coax Human Stem Cells into Becoming T Cells
Canadian researchers have developed a way to direct unspecified human stem cells into becoming progenitor T cells, which then go to the thymus and give rise to mature T cells, an essential ingredient in immune system reconstitution. [Sunnybrook Health Sciences Centre, Toronto]
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Scientists Find Common Trigger in Cancer and Normal Stem Cell Production
Researchers at the School of Medicine have discovered, for the first time, a common molecular pathway that is used by both normal stem cells and cancer stem cells when they reproduce themselves. [Stanford School of Medicine, Stanford]
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Mouse Tooth Grown From Stem Cells in Mouth
Researchers have created a “tooth germ” from mouse stem cells, which was implanted the 500-micrometer (0.02-inch) germ inside a mouse’s tooth socket. [Tokyo University of Science, Tokyo]
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Non-insulin-producing Alpha Cells in the Pancreas can be Converted to Insulin-producing Beta Cells
In findings that add to the prospects of regenerating insulin-producing cells in people with type 1 diabetes, researchers have shown that insulin-producing beta cells can be derived from non-insulin-producing cells in the pancreas. [Max-Planck Institute for Biophysical Chemistry, Munich]
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VIDEO: Researchers Identify Phosphorylated Signaling Proteins in Human Embryonic Stem Cells
Investigators have made the first comparative, large-scale phosphoproteomic analysis of human embryonic stem cells and their differentiated derivatives. [Burnham Institute for Medical Research, Burnham]
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Testing Gene Therapy to Improve Brain Function in Alzheimer’s Disease Patients
Researchers are about to launch a Phase 2 clinical trial to test a gene therapy treatment for Alzheimer’s disease called CERE-110, at 12 U.S. sites. [Shiley-Marcos Alzheimer’s Disease Research Center, University of California San Diego, San Diego]
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Proprietary Technology in World First Allogenic Stem Cell Trial for Treatment of End-Stage Heart Failure in Patients Supported By Mechanical Heart Assist Devices
Mesoblast Limited recently announced that its United States-based associate company Angioblast Systems Inc. has initiated a Phase 2 clinical trial for its adult stem cell product Revascor(TM) for improving heart muscle function in patients with class IV, end-stage form of heart failure. [Mesoblast Limited, Melbourne]
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Aldagen Reaches Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial of ALD-301 for Critical Limb Ischemia
The Phase 3 trial will be a double blind, placebo-controlled study designed to assess the ability of ALD-301 to improve clinical outcomes in patients with CLI, including amputation rates, ulcer healing and pain reduction. [Aldagen, Inc., Durham]
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ABSTRACTS, REVIEWS AND SPECIAL REPORTS
A Novel Human Gamma-globin Gene Vector for Genetic Correction of Sickle Cell Anemia in a Humanized Sickle Mouse Model: Critical Determinants for Successful Correction
This study shows that lentiviral delivery of human {gamma}-globin gene under {beta]-globin regulatory control elements in hematopoietic stem cells results in sufficient postnatal fetal hemoglobin expression to correct sickle cell anemia in the Berkeley “humanized” sickle mouse. [Blood]
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The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into {alpha} and Subsequently {beta} Cells
Here, the researchers conditionally and ectopically express Pax4 using different cell-specific promoters and demonstrate that Pax4 forces endocrine precursor cells, as well as mature {alpha} cells, to adopt a {beta} cell destiny. [Cell]
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Secreted Frizzled-Related Protein 1 Extrinsically Regulates Cycling Activity and Maintenance of Hematopoietic Stem Cells
This report explores secreted frizzled-related protein 1’s role in maintaining hematopoietic stem cells homeostasis through extrinsic regulation of -catenin. [Cell, Stem Cell]
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Engineering the Surface Glycoproteins of Lentiviral Vectors for Targeted Gene Transfer
This article provides an overview of innovative approaches to upgrade lentiviral vectors for tissue targeting. [Cold Spring Harbor Protocols]
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Gene Therapy and Bone Marrow Stem Cell Transfer to Treat Autoimmune Disease
Gene therapy combined with bone marrow stem cells has successfully introduced genes lacking in immunodeficiences. [Trends in Molecular Medicine]
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Doubts Over Stem Cell Images Prompt New Inquiry
The University of Minnesota in Minneapolis has launched yet another inquiry into research at its Stem Cell Institute after New Scientist raised further concerns about papers that seem to contain duplicated and manipulated images. [University of Minnesota in Minneapolis, Minneapolis]
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