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Researchers Identify a Coronary Vascular Progenitor Cell Capable of Growing New Coronary Arteries
Researchers recently demonstrated that the human heart contains a population of stem cells which has the unique property to form large vessels similar to those commonly affected by atherosclerosis, a disease which can lead to heart attack. [Brigham and Women’s Hospital, Boston]
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VIDEO: Nano-magnets Guide Stem Cells to Damaged Tissue
Microscopic magnetic particles have been used to bring stem cells to sites of cardiovascular injury in a new method designed to increase the capacity of cells to repair damaged tissue researchers recently announced. [University College London, London]
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Synaptotagmin Plays a Critical Role in Initiating Cellular Fusion
Success in cellular fusion — as occurs at the moment of conception and when nerve cells exchange neurotransmitters — requires that a membrane be bent before the merging process can begin researchers have shown. [University of Wisconsin-Madison, Madison]
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Scientists Grow Fully Functional Tooth from Stem Cells
Though teeth have been grown in mice before, scientists revealed their success at growing a "fully functional" tooth from stem cells in mice. [Tokyo University of Science, Tokyo]
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Watching Stem Cells Repair the Human Brain
Researcher shows viability of bone marrow stem cells with unique MRI tracking methods. [Tel Aviv University, Tel Aviv]
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Stemedica Cell Technologies, Inc. Requests Pre-IND Meeting With FDA
Stemedica Cell Technologies, Inc. has requested a pre-Investigational New Drug meeting with the U.S. Food and Drug Administration to discuss a proposed IND to use Stemedica’s proprietary line of allogeneic mesenchymal bone marrow cells as a treatment for ischemic stroke. [Stemedica Cell Technologies, Inc., San Diego]
Article
Geron’s IND for Spinal Cord Injury Placed on Hold
Geron Corporation recently announced that its investigational new drug application for GRNOPC1, a cell therapy for neurologically complete, subacute spinal cord injury, has been placed on clinical hold by the FDA pending the agency’s review of new nonclinical animal study data submitted by the company. [Geron, Menlo Park]
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Hard To Treat Diseases to Begin Stem Cell Graft Survival Study
Hard To Treat Diseases has begun preliminary experiments within a project aimed at Promoting stem cell graft survival in the model of traumatic brain injury in rats. [Hard To Treat Diseases, Belgrade]
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Treatment May Limit Graft-Versus-Host Disease
People who need a blood stem cell transplant may be able to lessen the chances of graft-versus-host disease by being treated with anti-T-cell globulin. [Universitatsklinikum Freiburg, Freiburg]
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Gentium Reports Top Line Results from the Phase III Treatment Trial of Defibrotide for Severe Veno-Occlusive Disease
Italian biopharmaceutical firm Gentium S.p.A. said its experimental drug to treat veno-occlusive disease, a complication of stem cell transplantation, missed the main goal of a late-stage study. [Gentium S.p.A., Villa Guardia]
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ABSTRACTS, REVIEWS AND SPECIAL REPORTS
In vivo Myocardial Distribution of Multipotent Progenitor Cells Following Intracoronary Delivery in a Swine Model of Myocardial Infarction
Using an anterior myocardial infarction swine model, near-infrared fluorescence was used for in vivo tracking of labeled [mesenchymal stromal cells, bone marrow mononuclear and peripheral blood mononuclear cells early after intracoronary injection. [European Heart Journal]
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The Natural and Engineered 3D Microenvironment as a Regulatory Cue During Stem Cell Fate Determination
This paper reviews the current understanding of 2D and 3D stem cell control mechanisms and proposes an approach to uncovering the mechanisms that govern stem cell behavior in 3D. [Tissue Engineering Part B: Reviews]
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Ovol2 Suppresses Cell Cycling and Terminal Differentiation of Keratinocytes by Directly Repressing c-Myc and Notch1
In this work, the researchers use HaCaT human keratinocytes to investigate the cellular and molecular functions of Ovol2. [Journal of Biological Chemistry]
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Senescence Impairs Successful Reprogramming to Pluripotent Stem Cells
This paper has identified has senescence as one barrier to somatic cells reprogrammed into induced pluripotent stem cells. [Cold Spring Harbor Laboratory Press]
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Senator Moves to Block Medical Ghostwriting
A growing body of evidence suggests that doctors at some of the nation’s top medical schools have been attaching their names and lending their reputations to scientific papers that were drafted by ghostwriters working for drug companies.
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