Growing Back a Lost Limb
An Israeli researcher has developed a biologically active ‘scaffolding’ of soluble fibers which could be used to regenerate lost or damaged bone and tissue. [Tel Aviv University, Tel Aviv]
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Muscle Cell Infusion Shown to Strengthen Sphincters in Animals
A new study shows that muscle cells grown in the lab can restore an intestine’s ability to squeeze shut properly. The work, performed in dogs and rats, might ultimately help treat patients with conditions such as gastric reflux and fecal incontinence. [Stanford University School of Medicine, Stanford]
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Study Results Suggests Adult Stem Cells May Help Repair Hearts Damaged by Heart Attack
Results from the Phase I study show stem cells from donor bone marrow appear to help heart attack patients recover better by growing new blood vessels to bring more oxygen to the heart. [Rush University Medical Center, Chicago]
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Kiadis Pharma Announces Enrollment of First Patients in a Multinational Registration Study for ATIRâ„¢
The study is designed to show reduction in transplant related mortality after one year following an allogeneic stem cell transplantation with a mismatched (haplo-identical) donor in blood cancer patients eligible for an allogeneic stem cell transplantation but without having a matched donor available. [Kiadis Pharma, Amsterdam]
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Clinical Trials Launched for Treating Most Aggressive Brain Tumour with Personalised Cell Vaccines
The University of Navarra Hospital has launched a series of clinical trials in order to assess the efficacy of an immunotherapy treatment involving the application of personalised vaccines designed to combat glioblastomas, one of the most aggressive and frequent malignant tumours. [University of Navarra Hospital, Pamplona]
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New Technique Could Revolutionize Stem Cell Transplants
Montreal researchers have developed a new approach that preserves the cells that fight infection and leukemia while eliminating the cells that reject donor cells. [Maisonneuve-Rosemont Hospital, Montreal]
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Neurologix Completes All Surgical Procedures in Its Clinical Trial for Parkinson’s Disease
Neurologix, Inc. announced the completion of all planned surgeries in an ongoing Phase 2 clinical trial of the company’s gene transfer approach to the treatment of advanced Parkinson’s disease. [Neurologix, Inc., Fort Lee]
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PUBLICATIONS, REVIEWS AND SPECIAL REPORTS
Cyclin E-dependent Protein Kinase Activity Regulates Niche Retention of Ovarian Follicle Stem Cells
Researchers identified a hypomorphic cyclin E allele WX that strongly impairs the maintenance of follicle stem cells in the Drosophila ovary but does not reduce follicle cell proliferation or germline stem cell maintenance. [PNAS]
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SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells
This study investigated whether skin-derived precursors might fulfill the role for an adult dermal stem cell. [Cell Stem Cell]
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Electrophysiological Properties of Human Induced Pluripotent Stem Cells
Previously, researchers reported that several specialized ion channels are functionally expressed in hESCs. Using transcriptomic analyses as a guide, TEA-sensitive (IC50 = 3.3 ± 2.7 mM) delayed rectifier K+ currents in 105 of 110 single iPSCs (15.4 ± 0.9 pF) was observed. [Am J Physiol Cell Physiol]
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