SCIENCE MyoD Helps Stem Cells Proliferate in Response to Muscle Injury
The master regulator of muscle differentiation, MyoD, functions early in myogenesis to help stem cells proliferate in response to muscle injury, according to researchers. [Case Western Reserve University, Cleveland] Needling Molecules
Researchers have developed a method using nanowires as needles to poke molecules into cells. If the method proves effective, it could greatly speed the ability to manipulate cells in a variety of applications, including stem cell reprogramming and drug screening. [Harvard University, Boston] Fake Skin Patches Could Deliver Helpful Genes
Patches of synthetic skin could deliver gene therapies to patients without the need for injections. [National Institutes of Health, Bethesda] Researchers Discover a Molecular Security System that Protects Human Cells from Potentially Harmful Foreign DNA
Researchers have discovered a molecular security system in human cells that deactivates and degrades foreign DNA. This discovery could open the door to major improvements in genetic engineering and gene therapy technologies. [University of Minnesota, Minneapolis] Regulatory Network Balances Stem Cell Maintenance, Differentiation
Working with the small roundworm Caenorhabditis elegans, researchers describe how a network of regulatory factors can maintain a stable pool of stem cells while launching a second pool of cells on the path toward maturing into differentiated cells with specific functions. [University of Wisconsin, Madison] Study Shows that Delivering Stem Cells Improves Repair of Major Bone Injuries in Rats
Recent studies show that delivering stem cells on a polymer scaffold to treat large areas of missing bone leads to improved bone formation and mechanical properties compared to treatment with the scaffold alone. [Georgia Institute of Technology, Atlanta] Human Immune Cells — In Mice
Researchers recently reported that they have engineered, for the first time, strains of mice that produce several types of human immune cells. Though the mice still do not express the full complement of immune cells, the work represents a big advance in generating so-called “humanized” mice. [Massachusetts Institute of Technology, Cambridge] Pluristem Therapeutics Announces Interim Results from PLX-PAD Clinical Trials
Pluristem Therapeutics Inc. recently announced interim results from their Phase I clinical trials utilizing their placenta derived cell therapy product, PLX-PAD, for the treatment of critical limb ischemia, the end-stage of peripheral artery disease. Data suggested that PLX-PAD is safe and potentially efficacious. [Pluristem Therapeutics Inc., Haifa] Stem Cell Therapeutics Corp. Announces Second Positive Review by Data Safety and Monitoring Board for the Modified REGENESIS Phase IIb Stroke Trial and Provides Corporate Update
Stem Cell Therapeutics Corp. announced it has been advised by the Data Safety Monitoring Board (DSMB) that its second regularly scheduled safety analysis has been completed and the DSMB has recommended for the Phase IIb acute ischemic stroke trial to continue as per protocol. [Stem Cell Therapeutics Corp., Calgary] University Hospitals Case Medical Center Testing Gene Therapy for Alzheimer’s Disease
University Hospitals Case Medical Center is one of 12 sites conducting the first Phase 2 clinical trial of a gene therapy for Alzheimer’s disease. The study uses a viral-based gene transfer system called CERE-110, which is designed to deliver nerve growth factor into the brain. [University Hospitals Case Medical Center, Cleveland] PUBLICATIONS, REVIEWS AND SPECIAL REPORTS Induced Pluripotent Stem Cells: One Cell to Rule Them All?
Rapid progress with induced pluripotent stem cells is bringing scientists closer to understanding their strengths and weaknesses as embryonic stem cell stand-ins. [Nat Methods] Human Neural Stem Cell Grafts Modify Microglial Response and Enhance Axonal Sprouting in Neonatal Hypoxic–Ischemic Brain Injury
The efficacy of human neural stem cells derived from human embryonic stem cells in a rat model of neonatal hypoxic–ischemic was investigated and the mechanisms enhancing brain repair. [Stroke] Multipotent Adult Progenitor Cell Isolation and Proliferation in Cytokine and Serum-Free Medium Conditioned by Rat B104 Cells
The isolation of rodent multipotent adult progenitor cells and proliferation of these cells in both standard medium and medium without exogenous serum or growth factors conditioned by the rat cell line B104 are described by investigators. [Br J Haematol] Synergistic Effect of Vascular Endothelial Growth Factor and Granulocyte Colony-Stimulating Factor Double Gene Therapy in Mouse Limb Ischemia
Local transient expression of vascular endothelial growth factor and stem cell mobilizer granulocyte colony-stimulating factor genes in ischemic limbs can complement their activities and be more efficient for limb recovery. [J Gene Med] Functional and Transcriptional Characterization of Human Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Myocardial Infarction
Researchers developed an extracellular matrix culture system for increasing endothelial differentiation and free from contaminating animal cells. Transcriptional changes that occur during endothelial differentiation of human embryonic stem cells using whole genome microarray were investigated, and compared to human umbilical vein endothelial cells. [PLoS One] Funding of US Biomedical Research, 2003-2008
With the exception of the American Recovery and Reinvestment Act, funding support for biomedical research in the United States has slowed after a decade of doubling. However, the extent and scope of slowing are largely unknown. [JAMA] 
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