SCIENCE NEWS Surprising New Clues on How to Build a Heart
New studies of how the heart develops in growing mouse embryos have brought researchers a step closer to understanding how to induce the body’s own cells to rebuild damaged coronary arteries. [Press release from Howard Hughes Medical Institute discussing online prepublication in Nature] Insulin-Like Signal Needed to Keep Stem Cells Alive in Adult Brain
Biologists have found a signal that keeps stem cells alive in the adult brain, providing a focus for scientists looking for ways to re-grow or re-seed stem cells in the brain to allow injured areas to repair themselves. [Press release from University of California, Berkeley discussing online prepublication in Current Biology] Secret to Healing Chronic Wounds Might Lie in Tiny Pieces of Silent RNA
Researchers discovered in a new animal study that an RNA segment, known as miR-210, in wounds with limited blood flow lowers the production of a protein that is needed to encourage skin cells to grow and close over the sore. [Press release from The Ohio State University discussing online prepublication in Proceedings of the National Academy of Sciences USA] Biologic Joint Reconstruction Using Stem Cells Proven Successful in Patients with Arthritis
Biologic Joint Reconstruction, rather than bionic replacement, may be an appropriate first step for many people with knee joint arthritis. [PRWeb Press Release] Scientists Share Secret of How Our Cells Make Us Tick
Scientists have defined the shape of a protein molecule at different stages as it performs a key activity within a cell – breaking down sugar to turn it into energy. [Press release from ScienceDaily discussing online prepublication in Journal of Biological Chemistry] “Good” Cells can Go “Bad” in a “Bad Neighborhood”
Researchers report that normal blood stem cells “are dependent upon their environment. They get their cues from the surrounding 'neighborhood' of bone cells,” says Scadden, co-director of the Harvard Stem Cell Institute and director of the MGH Center for Regenerative Medicine. [Press release from the Harvard Stem Cell Institute discussing the online prepublication in Nature] Aastrom Announces Treatment of Final Patient in RESTORE-CLI Clinical Trial
Aastrom Biosciences, Inc. reported that the final patient has been treated in the company's ongoing multi-center, randomized, double-blind, placebo-controlled U.S. Phase IIb clinical trial designated RESTORE-CLI. [Aastrom Biosciences, Inc. Press Release] Fish Show How to Fix a Broken Heart
Using advanced genetic tools, researchers now have identified key cells involved in zebrafish heart regeneration and begun to discover the instructions the cells use to carry out their repair work. [Press release from the Harvard Stem Cell Institute discussing online prepublication in Nature] Independent Studies Demonstrate that NellOne Therapeutics’ Protein Has Potential to Heal Damaged Skeletal and Heart Muscle
Two key, independent proof-of-concept studies conducted for NellOne Therapeutics, Inc. demonstrate the potential efficacy of the company’s lead therapeutic candidate for both skeletal muscle wound healing and myocardial infarction. [NellOne Therapeutics, Inc. Press Release] Garnet BioTherapeutics Announces First Patient Treated in Trial of New Therapy for Improvement in Scar Appearance
Garnet BioTherapeutics announced that the first patient has been treated in a Phase II multicenter, double-blind, placebo-controlled study of its lead product candidate GBT009 at Unity Hospital in Rochester, New York. [Garnet BioTherapeutics Press Release] CURRENT PUBLICATIONS Bone Progenitor Dysfunction Induces Myelodysplasia and Secondary Leukemia
By examining how mesenchymal osteolineage cells modulate hematopoiesis, researchers show that deletion of Dicer1 specifically in mouse osteoprogenitors, but not in mature osteoblasts, disrupts the integrity of hematopoiesis. [Nature] Zscan4 Regulates Telomere Elongation and Genomic Stability in Embryonic Stem Cells
Researchers show that Zscan4 is involved in telomere maintenance and long-term genomic stability in embryonic stem cells. [Nature] Primary Contribution to Zebrafish Heart Regeneration by gata4+ Cardiomyocytes
Results indicate that electrically coupled cardiac muscle regenerates after resection injury, primarily through activation and expansion of cardiomyocyte populations. [Nature] Zebrafish Heart Regeneration Occurs by Cardiomyocyte Dedifferentiation and Proliferation
The researchers' data provide the first direct evidence for the source of proliferating cardiomyocytes during zebrafish heart regeneration and indicate that stem or progenitor cells are not significantly involved in this process. [Nature] Inactivation of Both foxo and reaper Promotes Long-Term Adult Neurogenesis in Drosophila
Researchers show that the absence of adult neurogenesis in Drosophila results from the elimination of neural stem cells (neuroblasts) during development. [Curr Biol] Hypoxia Inducible MicroRNA 210 Attenuates Keratinocyte Proliferation and Impairs Closure in a Murine Model of Ischemic Wounds
These results are unique in presenting evidence demonstrating that the hypoxia component of ischemia may limit wound re-epithelialization by stabilizing HIF-1(alpha), which induces miR-210 expression, resulting in the down-regulation of the cell-cycle regulatory protein E2F3. [Proc Natl Acad Sci U S A] The Allosteric Mechanism of Pryuvate Kinase from Leishmania mexicana: a Rock and Lock Model
The results presented here illustrate how conformational changes coupled with effector binding correlate with loss of flexibility and increase in thermal stability providing a general mechanism for allosteric control. [J Biol Chem]
| 
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
