SCIENCE NEWSCombination Therapy Targets Stubborn Leukemia Stem Cells
New research discovers a combination of drugs that may prove to be a more effective treatment for a lethal form of leukemia. [Press release from Science Centric discussing online prepublication in Cancer Cell]Technique Might Boost Women's Fertility
Scientists have found a way to awaken dormant ovarian follicles, possibly making more eggs available for reproduction during a woman's lifespan. [Press release from Health Day discussing online prepublication in the Proceedings of the National Academy of Sciences USA] Oncolytic Viruses Mediating Anti-Tumor Immunity in Human Cancer Patients Published by Oncos Therapeutics and University of Helsinki
Oncos Therapeutics published initial results from its Advanced Therapy Access Program. The results demonstrate anti-tumor immunity of oncolytic viruses — published for the first time in humans — and indicate strong efficacy of the next generation viruses against solid tumor cancers. [Press release from Oncos Therapeutics discussing online prepublication in Cancer Research] Mayo Clinic Researchers Find Gene They Believe Is Key to Kidney Cancer
Researchers have discovered a key gene that, when turned off, promotes the development of common kidney cancer. Their findings suggest that a combination of agents now being tested in other cancers may turn the gene back on, providing a much-needed therapy for the difficult-to-treat cancer. [Press release from the Mayo Clinic discussing online prepublication in Oncogene] Spanish Researchers Reprogram Adult Stem Cells to Help Cardiac Muscle Regeneration
Spanish researchers have employed for the first time adult cells extracted from a human heart to turn stem cells from adipose tissue into cardiac myocytes. [Press release from The Medical News discussing online prepublication in Cytotherapy] Progress in Exploring New Avenues for Brain Repair
Researchers showed how astroglia can be directly converted into the two main classes of cortical neurons. [Press release from Ludwig-Maximilians University discussing online prepublication in PLoS Biology] Cellmedicine Stem Cell Clinic Case Report of Successful Treatment of Heart Failure Patient Published
The Cellmedicine Institutes reported publication of a heart failure patient who underwent profound recovery after receiving adult stem cell therapy. [Press release from Medical News Today discussing online prepublication in the International Archives of Medicine] Process of Cancer Cell Self-Digestion Is Target of New Cancer Therapies
In an effort to improve current anticancer treatments, investigators have been targeting autophagy. While preclinical studies have shown that inhibition of autophagy sensitizes tumor cells to treatment, researchers recently have had an opportunity to observe these effects in early-stage clinical trials involving a drug commonly used to treat malaria. [Press release from The Cancer Institute of New Jersey discussing research presented at the 2010 Annual Meeting of the American Society of Clinical Oncology] Estrogen-Lowering Drugs Minimize Surgery in Breast Cancer Patients
A nationwide study has confirmed the benefit of giving estrogen-lowering drugs before surgery to breast cancer patients. The treatment increased the likelihood that women could undergo breast-conservation surgery, also called lumpectomy, instead of mastectomy. [Press release from Washington University in St. Louis discussing research presented at the 2010 Annual Meeting of the American Society of Clinical Oncology] CA-125 Change Over Time Shows Promise as Screening Tool for Early Detection of Ovarian Cancer
Evaluating its change over time, CA-125, the protein long-recognized for predicting ovarian cancer recurrence, now shows promise as a screening tool for early-stage disease. [Press release from University of Texas M. D. Anderson Cancer Center discussing research presented at the 2010 Annual Meeting of the American Society of Clinical Oncology] Geron Announces Positive Study Data on GRNCM1
Geron Corporation reported positive preclinical study data showing that GRNCM1, Geron's cardiomyocyte product derived from human embryonic stem cells, does not cause cardiac arrhythmias after transplantation into a model of chronic heart damage designed to test this potential safety concern. [Press release from Geron Corporation] Amsterdam Molecular Therapeutics Reports Promising Data from Cholesterol Lowering Gene Therapy Study
Amsterdam Molecular Therapeutics reported positive preclinical data from a study using an adeno-associated virus gene therapy product to lower cholesterol. [Press release from Amsterdam Molecular Therapeutics] Jennerex Reports Positive Phase 1 Results for JX-594 Administered Intravenously
Jennerex, Inc. reported positive results from its Phase 1 dose escalation study evaluating the intravenous (IV) administration of JX-594 to patients with metastatic cancer. [Press release from Jennerex, Inc.] Celgene's Revlimid Positive in Maintenance Trials
According to preliminary data patients who took Revlimid on a continuous basis following a stem cell transplant kept their disease in check longer than those who took a placebo. [Press release from Reuters] CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome
Researchers report the design, synthesis, and assembly of the 1.08-Mbp Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a Mycoplasma capricolum recipient cell to create new Mycoplasma mycoides cells that are controlled only by the synthetic chromosome. [Science] Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate
Treatment with HDAC inhibitors combined with imatinib mesylate (IM) effectively induced apoptosis in quiescent chronic myelogenous leukemia (CML) progenitors resistant to elimination by IM alone, and eliminated CML stem cells capable of engrafting immunodeficient mice. [Cancer Cell] Sonic Hedgehog Is a Critical Mediator of Erythropoietin-Induced Cardiac Protection in Mice
These results suggest that erythropoietin protects the heart after myocardial infarction by inducing angiogenesis through sonic hedgehog signaling. [J Clin Invest] Activation of Dormant Ovarian Follicles to Generate Mature Eggs
Short-term in vitro activation of dormant ovarian follicles after stimulation of the PI3K-Akt pathway allows the generation of a large supply of mature female germ cells for future treatment of infertile women with a diminishing ovarian reserve and for cancer patients with cryo-preserved ovaries. [Proc Natl Acad Sci U S A] Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients
An oncolytic adenovirus coding for granulocyte macrophage colony-stimulating factor (GMCSF) was engineered and shown to induce tumor-specific immunity in an immunocompetent syngeneic hamster model. Subsequently, 20 patients with advanced solid tumors refractory to standard therapies were treated with Ad5-D24-GMCSF. [Cancer Res] Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons
Researchers show that strong and persistent expression of neurogenic fate determinants driven by silencing-resistant retroviral vectors instructs astroglia from the postnatal cortex in vitro to mature into fully functional, synapse-forming neurons. [PLoS Biology] 
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