SCIENCE NEWSTwelve New Genes Linked to Type 2 Diabetes Twelve new genes associated with type 2 diabetes have been identified in the largest study yet of the connections between differences in people’s DNA and their risk of diabetes. [Press release the University of Oxford discussing online prepublication in Nature Genetics]Virus Works with Gene to Cause Crohn's-Like Illness Scientists have shown that a specific virus can interact with a mutation in the host's genes to trigger disease. The observation may help explain why many people with disease risk genes do not actually develop disease. [Press release from Washington University School of Medicine discussing online prepublication in Cell] Scientists Implant Regenerated Lung Tissue in Rats Scientists report that they have achieved an important first step in regenerating fully functional lung tissue that can exchange gas. [Press release from Yale University discussing online prepublication in Science] Living, Breathing Human Lung-on-a-Chip: A Potential Drug-Testing Alternative Researchers have created a device that mimics a living, breathing human lung on a microchip. [Press release from the Wyss Institute for Biologically Inspired Engineering at Harvard University discussing online prepublication in Science] Microbial Protein Restores Vision in Blind Animals Neurobiologists have devised a gene therapeutic method to restore the functionality of the cone cells in models of retinitis pigmentosa. They used a light-sensitive protein called halorhodopsin from archaebacteria to re-establish vision. [Press release from the Friedrich Miescher Institute for Biomedical Research discussing online prepublication in Science] Researchers Create Self-Assembling Nanodevices That Move and Change Shape on Demand By emulating nature's design principles, researchers have created nanodevices made of DNA that self-assemble and can be programmed to move and change shape on demand. [Press release from the Wyss Institute for Biologically Inspired Engineering discussing online prepublication in Nature Nanotechnology] Studying Cells in 3D Could Reveal New Cancer Targets A new study indicates that viewing cell behavior in three dimensions could lead to important advances in cancer research. [Press release from Johns Hopkins University discussing online prepublication in Nature Cell Biology] New Lung Cancer Treatment Is Saving Lives Chemotherapy given after surgery for lung cancer improves overall survival rates in the general population. [Press release from Queen’s University discussing online prepublication in the Journal of Clinical Oncology] Molecular Discovery Suggests New Strategy to Fight Cancer Drug Resistance Scientists have found a way to disable a common protein that often thwarts chemotherapy treatment of several major forms of cancer. [Press release from Dana-Farber Cancer Institute discussing online prepublication in Nature Chemical Biology] Gene Linked to Blood Clots During Cancer Therapy A new study has found a gene mutation that can increase the risk of developing blood clots in breast cancer patients undergoing treatment with the drug tamoxifen. [Press release from BioNews discussing research published in the Journal of the National Cancer Institute] Scientists Capture Structure of Virus Changing During Infection Using intricate scientific techniques that involved freezing bacteria and virus and transporting in liquid nitrogen, scientists used powerful cryo-electron microscopes to determine how the structure of the virus changes during infection, allowing it to release its DNA into the cell. [Press release from the Baylor College of Medicine discussing online prepublication in Nature Structural and Molecular Biology] Control of Cancer Cell Pathways Key to Halting Disease Spread Scientists have deciphered a part of the pathway used by the oncogene called Myc to exert its malignant effect. Their findings confirm that at least some cancerous cells have within them the seeds to stop their own growth, if Myc can first be disabled. [Press release from Stanford University School of Medicine discussing online prepublication in Genes and Development] Multinational Research Team Sequences Body Louse Genome A global research team published a new study describing the sequencing and analysis of the body louse genome. [Press release from the J. Craig Venter Institute discussing online prepublication in the Proceedings of the National Academy of Sciences USA] Brain Scans Support Genes' Role in Alzheimer's Disease Scientists have confirmed that four suspect genes are tied to Alzheimer’s disease and linked the disease to two new genes, offering unexpected targets for future research. [Press release from the National Institutes of Health discussing online prepublication in the Archives of Neurology] Inovio Pharmaceuticals' Optimized DNA Vaccine Demonstrates Significant Advantages in Non-Human Primates Compared to Leading Viral Vector Based Vaccine Researchers noted that significant advances in the design, formulation, and delivery of DNA plasmid-based vaccines have dramatically increased their ability to induce antigen-specific immune responses. [Press release from Inovio Pharmaceuticals, Inc. discussing online prepublication in Molecular Therapy] CEL-SCI Collaborator Presents Data Showing LEAPS™ Vaccine Technology Generates Dendritic Cells That Can Protect Animals Against Viral Illness and Other Diseases CEL-SCI Corporation and researchers at the Northeastern Ohio Universities Colleges of Medicine and Pharmacy jointly announced that a LEAPS™-based vaccine (Ligand Epitope Antigen Presentation System) study has demonstrated the technology's potential using dendritic cells to stimulate the immune system to fight viral illnesses and other diseases. [Press release from CEL-SCI Corporation discussing online prepublication in Vaccine] University of Texas Medical Branch Grows Lung from ‘Skeletons’ Specialists in the field of tissue engineering have been frustrated by the problem of coaxing undifferentiated stem cells to develop into the specific cell types that populate different locations in the lung. Now, researchers have demonstrated a potentially revolutionary solution to this problem. [Press release from the University of Texas Medical Branch discussing online prepublication in Tissue Engineering Part A] Identification of a Novel Tumor Suppressor Scientists have identified a novel tumor suppressor playing an important role in T-cell lymphoma. The protein kinase NDR1 has so far been implicated in the processes controlling cell death and centrosome duplication. [Press release from the Friedrich Miescher Institute for Biomedical Research discussing online prepublication in Science Signaling] Building a Substitute Pancreas for Diabetics Implants containing specially wrapped insulin-producing cells derived from embryonic stem cells can regulate blood sugar in mice for several months. [Press release from MIT Technology Review discussing research presented at the 8th Annual Meeting of the International Society for Stem Cell Research] Scientists Successfully Engineer Heart Tissue Scientists in China have successfully engineered myocardial tissue that is likely to share structural and functional similarities with natural myocardium. [Press release from the World Heart Federation discussing research presented at the World Congress of Cardiology 2010] Stem Cells Offer Hope in Cerebral Palsy Battle Researchers have begun a U.S. Food and Drug Administration-authorized random clinical trial to see if cord blood stem cells have the ability to cure or lessen spastic cerebral palsy in children aged 1 to 6. [Triangle Business Journal] Gene Therapy a Step Closer to Mass Production Researchers have synthesized and studied a range of organic compounds able to carry genetic material into individual cells where it can remedy the diseases caused by defective genes. Still under development, these compounds are much more readily produced than the viral carriers now in use and avoid their side-effects. [EUREKA Network Press Release] Neurologix Announces Successful Phase II Trial of Gene Therapy for Parkinson's Disease Neurologix, Inc. announced positive results in a Phase II trial of its investigational gene therapy for advanced Parkinson's disease, NLX-P101. [Neurologix, Inc. Press Release] Cellonis Diabetes Stem Cell Therapy: A Chance for Insulin Independence and the Reversal of Complications A new personalized diabetes treatment concept has demonstrated an amazing improvement in treated patients’ conditions. The ongoing clinical study shows the treatment’s best case could reconstruct a patient’s natural insulin production and even reverse later complications like kidney failure. [Cellonis Press Release] Mologen AG Receives Approval for Clinical Study with Cell-Based Gene Therapy Against Renal Cancer Mologen AG has received approval from the Paul-Ehrlich-Institut to carry out a Phase I/II clinical study with its innovative new MGN1601 cancer medicine. MGN1601 is a cell-based gene therapy for the treatment of advanced renal cancer. [Mologen Press Release] CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Limbal Stem-Cell Therapy and Long-Term Corneal Regeneration Cultures of limbal stem cells represent a source of cells for transplantation in the treatment of destruction of the human cornea due to burns. [N Engl J Med] Genome-Wide Meta-Analyses Identifies Seven Loci Associated with Platelet Aggregation in Response to Agonists Researchers identified associations of seven loci with platelet aggregation near or within GP6, PEAR1, ADRA2A, PIK3CG, JMJD1C, MRVI1 and SHH. [Nat Genet] Twelve Type 2 Diabetes Susceptibility Loci Identified Through Large-Scale Association Analysis By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, researchers identified 12 new T2D association signals. [Nat Genet] Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine Researchers provide a specific example of how a virus-plus-susceptibility gene interaction can, in combination with additional environmental factors and commensal bacteria, determine the phenotype of hosts carrying common risk alleles for inflammatory disease. [Cell] Tissue-Engineered Lungs for In Vivo Implantation To explore whether lung tissue can be regenerated in vitro, researchers treated lungs from adult rats using a procedure that removes cellular components but leaves behind a scaffold of extracellular matrix that retains the hierarchical branching structures of airways and vasculature. [Science] Reconstituting Organ-Level Lung Functions on a Chip Researchers describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary interface of the human lung. [Science] Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa Researchers show that expression of archaebacterial halorhodopsin in light-insensitive cones can substitute for the native phototransduction cascade and restore their light sensitivity in mouse models of retinitis pigmentosa. [Science] Self-Assembly of Three-Dimensional Prestressed Tensegrity Structures from DNA Researchers report nanoscale, prestressed, three-dimensional tensegrity structures in which rigid bundles of DNA double helices resist compressive forces exerted by segments of single-stranded DNA that act as tension-bearing cables. [Nat Nanotechnol] The MCL-1 BH3 Helix Is an Exclusive MCL-1 Inhibitor and Apoptosis Sensitizer By leveraging nature's solution to ligand selectivity, researchers generated an MCL-1–specific agent that defines the structural and functional features of targeted MCL-1 inhibition. [Nat Chem Biol] Structural Changes in a Marine Podovirus Associated with Release of Its Genome into Prochlorococcus Observations suggest a mechanism whereby, upon binding to the host cell, the tail fibers induce a cascade of structural alterations of the portal vertex complex that triggers DNA release. [Nat Struct Mol Biol]
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