SCIENCE NEWSResearchers Create First Molecule Able to Block Key Component of Cancer Genes' On-Off Switch In the quest to arrest the growth and spread of tumors, there have been many attempts to get cancer genes to ignore their internal instruction manual. In a new study, scientists have created the first molecule able to prevent cancer genes from “hearing” those instructions, stifling the cancer process at its root. [Press release from the Dana-Farber Cancer Institute discussing online prepublication in Nature]Gene Variations that Alter Key Enzyme Linked to Prostate Cancer Researchers at the National Institutes of Health have found that variations in a gene for an enzyme involved in cell energy metabolism appear to increase the risk for prostate cancer. [Press release from the National Institutes of Health discussing online prepublication in the Journal of Clinical Endocrinology and Metabolism] Sodium Plays Key Role in Tissue Regeneration: New Drug Treatment Triggers Sodium Ions to Regrow Nerves and Muscle; Could Extend Treatment Window for Acute Injuries Biologists have discovered that sodium plays a key role in initiating a regenerative response after severe injury. Scientists have found a way to regenerate injured spinal cord and muscle by using small molecule drugs to trigger an influx of sodium ions into injured cells. [Press release from Tufts University discussing online prepublication in the Journal of Neuroscience] Jevtana® Improves Survival in Advanced Prostate Cancer Patients Sanofi-aventis announced that data from the Phase III TROPIC study, which was the basis for the June 2010 U.S. Food and Drug Administration (FDA) approval of Jevtana® (cabazitaxel) Injection, was published in the October 2 issue of The Lancet in an article titled “Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.” [Press release from Sanofi-aventis discussing online prepublication in The Lancet] Yale Researchers Find Protein is a Key Tool in Chromosomal Repair Kit Scientists have discovered how one protein plays a key role in repairing damage to chromosomes that can cause different types of cancer. [Press release from Yale University discussing online prepublication in Nature Structural & Molecular Biology] Triple-Negative Breast Cancers May Have Unique Therapeutic Target Patients with triple-negative breast cancer, one of the hardest subtypes to treat, may have a unique biomarker that would enable them to receive more targeted therapy. [Press release from the American Association for Cancer Research (AACR) discussing data presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development] Circulating Tumor Cells Can Provide 'Real-time' Information on Patient's Current Disease State Circulating tumor cells may be a promising alternative, noninvasive source of tumor materials for biomarker assessment. [Press release from the American Association for Cancer Research (AACR) discussing data presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development] Novel Biomarker May Predict Response to New VEGF Receptor Inhibitor Researchers believe there may be a way to predict, based on individual tumors, those patients who are more likely to respond to the investigational new drug tivozanib. [Press release from the American Association for Cancer Research (AACR) discussing data presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development] Proteins To Yield New Clues in Fight Against Osteoporosis A $1.76 million study at Rensselaer Polytechnic Institute seeks to identify new methods of diagnosing osteoporosis and inform the development of next-generation drugs to treat the bone disease. [Rensselaer Polytechnic Institute Press Release] Technique to Reattach Teeth Using Stem Cells Developed at UIC A new approach to anchor teeth back in the jaw using stem cells has been developed and successfully tested in the laboratory for the first time by researchers at the University of Illinois at Chicago. [Press release from the University of Illinois at Chicago discussing online prepublication in Tissue Engineering] MicroRNA Panel Provides a More Precise Lung Cancer Diagnosis A test based on a panel of microRNAs under development by Rosetta Genomics, Ltd., in Rehovot, Israel, may allow for more precise diagnosis and better targeted therapy for patients with lung cancer. [ScienceDaily Press Release] Scientists Stack Up New Genes for Height An international team of researchers has discovered hundreds of genes that influence human height. [Press release from the University of North Carolina at Chapel Hill School of medicine discussing online prepublication in Nature] Addition of Immunotherapy Boosts Pediatric Cancer Survival in Children With Neuroblastoma Administering a new form of immunotherapy to children with neuroblastoma increased the percentage of those who were alive and free of disease progression after two years, according to researchers at the University of California, San Diego School of Medicine and fellow institutions. [Press release from ScienceDaily discussing online prepublication in the New England Journal of Medicine] Research on Killer HIV Antibodies Provides Promising New Ideas for Vaccine Design Rockefeller researchers have made two fundamental new discoveries about the immune defenses of a rare group of HIV patients whose bodies can naturally keep the virus at bay. [Press release from The Rockefeller University discussing online prepublication in Nature] Rescue Services at the Cellular Level: How Stem Cells Help the Brain to Regain its Functions After a Stroke A study has now demonstrated, in a long-term animal study on rats, that the positive effect of stem cell injection after a stroke is mainly based on a stimulative effect in the surrounding cell region. [Press release from the Max Planck Institute for Neurological Research in Cologne discussing online prepublication in PLoS ONE] Scientists Discover Gene that Controls Stem Cells in Central Nervous System Scientists at the Medical Research Council have discovered that a gene called Sox9 plays a critical role in how stem cells behave and is crucial in the development of the central nervous system. [Press release from the Medical Research Council discussing online prepublication in Nature Neuroscience] Arizona Cancer Center-TGen-Mayo Study Finds Gene Associated with Aggressive Skin Cancer The loss of a gene known as INPP5A could predict the onset and track the progression of an aggressive type of skin cancer, according to a study. [Press release from the Arizona Cancer Center discussing online prepublication in Cancer Prevention Research] Synosia Presents Data from Clinical Trial of SYN-118 As A New Treatment For Parkinson's Disease Synosia Therapeutics announced the first clinical study results showing that SYN-118 provides clinically meaningful benefits to Parkinson’s patients, has a good safety profile and is well tolerated. [Synosia Therapeutics Press Release] CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Anti-GD2 Antibody with GM-CSF, Interleukin-2, and Isotretinoin for Neuroblastoma Researchers conducted a study to determine whether adding ch14.18, GM-CSF, and interleukin-2 to standard isotretinoin therapy after intensive multimodal therapy would improve outcomes in high-risk neuroblastoma. [New Engl J Med] Selective Inhibition of BET Bromodomains The data establishes proof-of-concept for targeting protein–protein interactions of epigenetic ‘readers’, and provides a versatile chemical scaffold for the development of chemical probes more broadly throughout the bromodomain family. [Nature] Hundreds of Variants Clustered in Genomic Loci and Biological Pathways Affect Human Height Here, using 183,727 individuals, researchers show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. [Nature] Polyreactivity Increases the Apparent Affinity of Anti-HIV Antibodies by Heteroligation Here, researchers show that during the human antibody response to HIV, somatic mutations that increase antibody affinity also increase breadth and neutralizing potency. [Nature] Prednisone Plus Cabazitaxel or Mitoxantrone for Metastatic Castration-Resistant Prostate Cancer Progressing After Docetaxel Treatment: a Randomised Open-Label Trial Researchers aimed to compare the efficacy and safety of cabazitaxel plus prednisone with those of mitoxantrone plus prednisone in men with metastatic castration-resistant prostate cancer with progressive disease after docetaxel-based treatment. [Lancet] Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA Here researchers describe a simple, nonintegrating strategy for reprogramming cell fate based on administration of synthetic mRNA modified to overcome innate antiviral responses. [Cell Stem Cell] SOX9 Induces and Maintains Neural Stem Cells Data identifies a functional link between extrinsic and intrinsic mechanisms of neural stem cell specification and maintenance, and establish a central role for SOX9 in the process. [Nat Neurosci] Cooperation of Breast Cancer Proteins PALB2 and Piccolo BRCA2 in Stimulating Homologous Recombination Inherited mutations in human PALB2 are associated with a predisposition to breast and pancreatic cancers. The studies provide the first biochemical insights into PALB2's function with piccolo BRCA2 as a mediator of homologous recombination in DNA double-strand break repair. [Nat Struct Mol Biol] Induction of Vertebrate Regeneration by a Transient Sodium Current Whereas voltage-gated sodium channels play a well known and important role in propagating action potentials in excitable cells, researchers have identified a novel role in regeneration for the ion transport function mediated by the voltage-gated sodium channel, NaV1.2. [J Neurosci] Phosphodiesterase 11A (PDE11A) Genetic Variants May Increase Susceptibility to Prostatic Cancer The data suggest that, like in the adrenal cortex and the testicular germ cells, PDE11A-inactivating genetic alterations may play a role in susceptibility to prostatic cancer. [J Clin Endocrinol Metab] Stem Cell Mediation of Functional Recovery after Stroke in the Rat In order to address the underlying mechanisms of stem cell mediated functional improvement, this functional improvement after stroke in the rat was investigated for six months after stroke by use of fMRI, somatosensory evoked potentials by electrophysiology, and sensorimotor behavior testing. [PLoS ONE]
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