TOP STORY | Precision Gene Targeting in Stem Cells Corrects Disease-Causing Mutations Using two distinct methods, researchers have successfully and consistently manipulated targeted genes in both human embryonic stem cells and induced pluripotent stem cells. [Press release from the Whitehead Institute for Biomedical Research discussing online prepublication in Cell and Nature Biotechnology] | SUBMIT A RESPONSE TO OUR INTERACTIVE POLL | | SCIENCE NEWS | Case Western Reserve University School of Medicine Restores Breathing After Spinal Cord Injury in Rodent Model Researchers bridged a spinal cord injury and biologically regenerated lost nerve connections to the diaphragm, restoring breathing in an adult rodent model of spinal cord injury. [Press release from Case Western Reserve University School of Medicine discussing online prepublication in Nature]
Efficient Process Using MicroRNA Converts Human Skin Cells into Neurons, Study Shows The addition of two particular gene snippets to a skin cell’s usual genetic material is enough to turn that cell into a fully functional neuron, report researchers. [Press release from Stanford School of Medicine discussing online prepublication in Nature]
Editing the Genome Researchers developing genome-scale editing tools have rewritten the genome of living cells using the genetic equivalent of search and replace—and combined those rewrites in novel cell strains, strikingly different from their forebears. [Press release from Harvard Medical, Dental and Public Health Schools discussing online prepublication in Science]Stem Cell Breakthrough Heralds New Era of Therapy Development Scientists have uncovered a new method for culturing adult stem cells which could lead to the creation of revolutionary stem cell therapies for conditions such as arthritis, Alzheimer’s disease and Parkinson’s disease. [Press release from the University of Glasgow discussing online prepublication in Nature Materials] Stem Cell “Memory” Can Boost Insulin Levels Researchers capitalizing on the “memories” of stem cells generated from adult cells to bring new hope to sufferers of juvenile or type 1 diabetes. [Press release from Tel Aviv University discussing online prepublication in Cell Stem Cell]
Stem Cells Restore Cognitive Abilities Impaired by Brain Cancer Treatment Research with rats found that stem cells transplanted two days after cranial irradiation restored cognitive function, as measured in one- and four-month assessments. [Press release from the University of California, Irvine discussing online prepublication in Cancer Research]
New Technique Boosts Efficiency of Blood Cell Production from Human Stem Cells Scientists have developed an improved technique for generating large numbers of blood cells from a patient’s own cells. [Press release from the Salk Institute for Biological Studies discussing online prepublication in Stem Cells]Experts Grow Whole Tooth Units Using Mouse Stem Cells Scientists said they have created teeth — complete with connective fibers and bones — by using mouse stem cells and successfully transplanted them into mice. [Press release from Reuters discussing online prepublication in PLoS One]
Celprogen Announces Development of Neuronal Stem Cells Derived from Adult Human Brains; May Someday Be an Effective Therapy for Alzheimer’s Patients Celprogen has developed neuronal stem cells that can be differentiated into neurons as an alternative for cell based therapy for neurological diseases including Alzheimer’s patients. [Celprogen Inc. Press Release]
Researchers Begin First Stem Cell Trials to Treat Eye Diseases Researchers have begun two clinical trials to determine the safety of stem cell therapy and patients’ ability to tolerate it for the treatment of two common, currently untreatable degenerative eye diseases. [University of California, Los Angeles Press Release]Study Uses New Stem Cell Therapy in Patients Up to 19 Days After Stroke The first Texas patient has been enrolled by researchers in the country’s first double-blind clinical trial studying the safety and efficacy of an innovative stem cell therapy that can be given up to 19 days after an ischemic stroke. [The University of Texas Health Science Center at Houston Press Release]
| POLICY | Stem Cell Policy Receives Updates The Executive Board approved revisions to the American Veterinary Medical Association’s policy on stem cells that reflect the changing face of stem cell research and stem cell–based therapies. [The American Veterinary Medical Association, United States] House Spending Panel Punishes OSTP Over Links to China The Congress cuts the White House Office of Science and Technology Policy (OSTP)’s 2012 budget by 55%, from the current $6.65 million to $3 million. [White House Office of Science and Technology Policy, United States] Task Force: No Need to Pull Research Council Out of European Commission Despite their often tumultuous relationship, there is no need to cut the European Research Council loose from the European Commission and create a new, independent organization to manage it, a task force said in a report issued. [European Research Council, European Union] NICE Seen at Heart of New UK Drug Pricing System Britain’s cost-effectiveness health watchdog the National Institute for Health and Clinical Excellence (NICE) expects to play a central role in a value-based pricing system for new medicines due to take effect from 2014, according to its chief executive. [National Institute for Health Clinical Excellence, United Kingdom] | BUSINESS | NeoStem Signs Definitive Merger Agreement to Acquire Amorcyte in Equity Transaction NeoStem, Inc. announced the signing of a definitive merger agreement whereby NeoStem will acquire Amorcyte, Inc. [Neostem, Inc. Press Release]
Family Foundation of Business Leader Invests $4.55 Million In Northwest Biotherapeutics for Promising Clinical Trials In the US and Europe Northwest Biotherapeutics announced a $4.55 million equity investment on June 28, 2011, by The Richard M. Schulze Family Foundation. [Northwest Biotherapeutics Press Release] NIH Supports New Research Strategy for Finding a Cure for HIV An international team led by researchers from the University of California, San Francisco and the nonprofit Vaccine and Gene Therapy Institute has received a major grant from the National Institutes of Health (NIH) to develop a strategy to eradicate HIV from the body. [University of California, San Francisco Press Release] Hutchinson Center to Lead a $20 Million Research Project to Explore a Potential Cure for HIV Infection Whether a stem cell transplant using an HIV-infected person’s own genetically modified immune cells can become a cure for the disease is the focus of a new $20 million, five-year research grant award announced by the National Institutes of Health to Fred Hutchinson Cancer Research Center. [Fred Hutchinson Cancer Research Center Press Release] Cancer Research UK Invests in Future World-Leading Scientists Cancer Research UK has given a number of prestigious grants to new investigators who are set to become the eminent cancer scientists of the future. [Cancer Research UK Press Release] European Patent OK’d for iPSC Technology of Kyoto Univ.’s Yamanaka The European Patent Office has approved a patent for Kyoto University professor Shinya Yamanaka’s technology for creating induced pluripotent stem cells (iPSCs) the university said. [The Mainichi Daily News] Alnylam Files Clinical Trial Application (CTA) for ALN-PCS, an RNAi Therapeutic Targeting PCSK9 for the Treatment of Severe Hypercholesterolemia Alnylam Pharmaceuticals, Inc. announced that it has filed a CTA with the Medicines and Healthcare products Regulatory Agency to initiate a Phase I clinical trial with ALN-PCS, an RNAi therapeutic for the treatment of severe hypercholesterolemia. [Alnylam Pharmaceuticals, Inc. Press Release] | |
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