TOP STORY | Generation of Chimeric Rhesus Monkeys Here, researchers demonstrate that rhesus monkey embryonic stem cells (ESCs) and isolated inner cell masses fail to incorporate into host embryos and develop into chimeras. However, chimeric offspring were produced following aggregation of totipotent cells of the four-cell embryos. [Cell] Abstract | Press Release
| PUBLICATIONS (Ranked by Impact Factor of the Journal) | Adult Human RPE Can Be Activated into a Multipotent Stem Cell that Produces Mesenchymal Derivatives This study establishes the retinal pigment epithelial (RPE) stem cell as an accessible, human CNS-derived multipotent stem cell, useful for the study of fate choice, replacement therapy, and disease modeling. [Cell Stem Cell] Abstract | Press Release Rejuvenation of Regeneration in the Aging Central Nervous System Here researchers show that remyelination of experimentally induced demyelination is enhanced in old mice exposed to a youthful systemic milieu through heterochronic parabiosis. [Cell Stem Cell] Abstract | Press Release Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice Researchers found that Polg-Mutator mice had neural (NSC) and hematopoietic progenitor (HPC) dysfunction already from embryogenesis. N-acetyl-L-cysteine treatment rescued both NSC and HPC abnormalities, suggesting that subtle ROS/redox changes, induced by mtDNA mutagenesis, modulate somatic stem cell function. [Cell Metab] Abstract | Press Release Essential Features and Rational Design of CRISPR RNAs that Function with the Cas RAMP Module Complex to Cleave RNAs Researchers show that CRISPR-associated (Cas) RAMP module CRISPR RNAs (crRNAs) contain an 8 nucleotide 5 sequence tag (also found on crRNAs associated with other CRISPR-Cas pathways) that is critical for crRNA function and can be used to engineer crRNAs that direct cleavage of novel targets. [Mol Cell] Abstract | Press Release
Implantation Site and Lesion Topology Determine Efficacy of a Human Neural Stem Cell Line in a Rat Model of Chronic Stroke Magnetic resonance imaging here confirmed stroke damage and allowed the targeted injection of 450,000 human neural stem cells into peri-infarct tissue, rather than the lesion cyst. [Stem Cells] Abstract | Press Release Foamy Virus Vector-Mediated Gene Correction of a Mouse Model of Wiskott–Aldrich Syndrome In this study, researchers assessed the use of foamy virus vectors as a gene transfer system for Wiskott–Aldrich syndrome (WAS), using a Was knockout mouse model. [Mol Ther] Abstract Concomitant Intravenous Nitroglycerin with Intracoronary Delivery of AAV1.SERCA2a Enhances Gene Transfer in Porcine Hearts In an effort to enhance the efficiency and homogeneity of gene uptake in cardiac tissue, investigators examined the effects of nitroglycerin in a porcine model following AAV1.SERCA2a gene delivery. [Mol Ther] Abstract Combined Tbet and IL12 Gene Therapy Elicits and Recruits Superior Antitumor Immunity In Vivo This study was undertaken to determine whether gene therapy using combined Tbet and interleukin (IL)-12 complementary DNA would yield improved antitumor efficacy based on the complementary/synergistic action of these biologic modifiers. [Mol Ther] Abstract Discovering Small Molecules that Promote Cardiomyocyte Generation by Modulating Wnt Signaling Researchers have developed a robust in vivo small-molecule screen that modulates heart size and cardiomyocyte generation in zebrafish. Increased cardiomyocyte number in Cardionogen-treated embryos was due to expansion of cardiac progenitor cells. [Chem Biol] Abstract Targeted Lentiviral Vectors Pseudotyped with the Tupaia paramyxovirus Glycoproteins Researchers demonstrate here that lentiviral vectors can also be pseudotyped with the glycoproteins of Tupaia paramyxovirus, the hemagglutinin and fusion protein. [Gene Ther] Abstract The Effects of Mechanical Stress on the Growth, Differentiation, and Paracrine Factor Production of Cardiac Stem Cells In this study, human cardiac stem cells were seeded in a silicon chamber and mechanical stress was then induced by cyclic stretch stimulation (60 cycles/min with 120% elongation). [PLoS One] Abstract Muscle-Derived Stem/Progenitor Cell Dysfunction Limits Healthspan and Lifespan in a Murine Progeria Model Here researchers show that muscle-derived stem/progenitor cells (MDSPCs) from old and progeroid mice are defective in proliferation and multilineage differentiation. Intraperitoneal administration of MDSPCs, isolated from young wild-type mice, to progeroid mice confer significant lifespan and healthspan extension. [Nat Commun] Abstract | Press Release
| BUSINESS | Alnylam and Arrowhead Form Collaboration and Licensing Agreement Alnylam Pharmaceuticals, Inc. and Arrowhead Research Corporation announced that they have entered into a collaboration and joint licensing agreement. [Alnylam Pharmaceuticals, Inc.] Press Release Osiris Therapeutics Provides Update on Groundbreaking Stem Cell Trial for Type 1 Diabetes Osiris Therapeutics, Inc. provided an update on its Phase II trial evaluating Prochymal, a formulation of adult mesenchymal stem cells, in patients with newly diagnosed type 1 diabetes. [Osiris Therapeutics, Inc.] Press Release Phase III Clinical Trial Begins for Prostate Cancer Immunotherapy Advantagene Inc. and the University of Massachusetts Medical School have announced the beginning of a Phase III clinical study to test the ability of a novel immunotherapy to kill tumor cells and stimulate a patient-specific anti-tumor immune response for patients newly diagnosed with localized prostate cancer. [The University of Massachusetts Medical School] Press Release
ThermoGenesis Announces Approval of AXP® by India Ministry of Health ThermoGenesis Corp. said that India’s Ministry of Health has approved the AutoXpress® System (AXP), enabling the Company to initiate commercial sales of the product in India. The AXP is used for the processing of stem cells from cord blood. [ThermoGenesis Corp.] Press Release
Neuralstem’s NSI-189 Trial in Major Depressive Disorder Receives FDA Approval to Advance to Phase Ib Neuralstem, Inc. announced that it has been approved by the Food and Drug Administration (FDA) to advance to Phase Ib in its ongoing clinical trial to test its novel neuroregenerative compound, NSI-189, for the treatment of major depressive disorder. [Neuralstem, Inc.] Press Release
AlloCure’s Investigational Treatment for Acute Kidney Injury Receives Fast Track Designation by FDA AlloCure, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to AC607, the company’s investigational treatment for acute kidney injury. [AlloCure, Inc.] Press Release Amsterdam Molecular Therapeutics Receives US Orphan Designation for Hemophilia B Gene Therapy Amsterdam Molecular Therapeutics announced that the U.S. Food and Drug Administration has granted orphan drug designation to its gene therapy program for the treatment of hemophilia B. [Amsterdam Molecular Therapeutics] Press Release Athersys Receives U.S. Patent Covering the Treatment of Cardiovascular Disease with Adult Stem Cells Athersys, Inc. announced that it has been granted U.S. patent 8,075,881 that covers the use of non-embryonic multipotent stem cells for the treatment of cardiovascular conditions including myocardial infarction, or heart attack, congestive heart failure, myocardial ischemia and other heart conditions. [Athersys, Inc.] Press Release Alnylam Files Clinical Trial Application for ALN-TTR02, an RNAi Therapeutic Targeting Transthyretin for the Treatment of Transthyretin-Mediated Amyloidosis Alnylam Pharmaceuticals, Inc. announced that it has filed a Clinical Trial Application with the U.K. Medicines and Healthcare products Regulatory Agency to initiate a Phase I clinical trial with ALN-TTR02, an RNAi therapeutic targeting transthyretin (TTR) for the treatment of TTR-mediated amyloidosis. [Alnylam Pharmaceuticals, Inc.] Press Release Dicerna Pharmaceuticals Appoints Life Sciences Executive James B. Weissman to Chief Business Officer Dicerna Pharmaceuticals, Inc. announced the appointment of James B. Weissman to chief business officer. [Dicerna Pharmaceuticals, Inc.] Press Release Tengion Announces Relocation of Corporate Headquarters to Current Facility in Winston-Salem, North Carolina Tengion, Inc. announced it has completed the relocation of its corporate headquarters from East Norriton, Pennsylvania to the Company’s existing facility in Winston-Salem, North Carolina. [Tengion, Inc.] Press Release
Major US Research Award for Professor Frank Barry One of Ireland’s leading scientists working in the field of stem cell therapy is to receive the 2012 Marshall R. Urist Award for Excellence in Tissue Regeneration Research. [The National University of Ireland, Galway] Press Release | JOB OPPORTUNITIES | Research and Development Technologist, hPSC Media (STEMCELL Technologies)
Scientist – Pluripotent Stem Cells (STEMCELL Technologies) Research Technologist, Manufacturing Sciences (STEMCELL Technologies) Business Analyst – Product Management (STEMSOFT Software) Postdoctoral Fellow – Adult Neurogenesis and Neural Signaling (University of Kentucky) Postdoctoral Position (The Laboratory for Equine and Comparative Orthopedic Research) Research Associate II/III (Louisiana State University) Associate Professor, Biology and Medicine in Maternal, Perinatal and Child Health (Wayne State University) Postdoctoral Position – Center for Human Genetics (VIB Research Institute)
Senior Development Associate (Genzyme Corporation)
Scientist II, Innovation – Cell Processing Technologies (Lonza Walkersville, Inc.)
Senior Manager, Innovation – Cell Processing Technologies (Lonza Walkersville, Inc.)
Postdoctoral/Research Associate (Children’s Memorial Research Center) Postdoctoral Fellow – Program in Children’s Regenerative Medicine (The University of Texas Medical School at Houston)
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