Cell Therapy News Volume 13.11 | Apr 4 2022

    By
    Justin.choi
    -
    0
    35







    2022-04-04 | CTN 23.11


    Cell Therapy News by STEMCELL Technologies
    Vol. 23.11 – 4 April, 2022
    TOP STORY

    Generation of SIV-Resistant T Cells and Macrophages from Nonhuman Primate Induced Pluripotent Stem Cells with Edited CCR5 Locus

    Scientists report successful targeting of the CCR5 locus in iPSCs generated from T cells or fibroblasts from Mauritian cynomolgus macaques, using CRISPR-Cas9 technology.
    [Stem Cell Reports]

    AbstractPress Release
    Win an Immunology Podcast Bluetooth speaker!
    PUBLICATIONSRanked by the impact factor of the journal

    Dissecting the Cellular Components of Ex Vivo γδ T Cell Expansions to Optimize Selection of Potent Cell Therapy Donors for Neuroblastoma Immunotherapy Trials

    Researchers characterized γδ T cell expansions from healthy adult donors and observe that highly potent natural killer lymphocytes expand with γδ T cells under zoledronate and IL-2 stimulation.
    [OncoImmunology]

    Full Article

    Efficient Isolation of Human Gingival Stem Cells in a New Serum-Free Medium Supplemented with Platelet Lysate and Growth Hormone for Osteogenic Differentiation Enhancement

    T cell proliferation and phenotype were also assessed by flow cytometry using cell proliferation dye and specific surface markers. Data were analysed with t-test for two-group comparisons, one-way ANOVA for multigroup comparisons and two-way ANOVA for repeated measures and multigroup comparisons.
    [Stem Cell Research & Therapy]

    Full Article

    The Transplantation of Rapamycin-Treated Senescent Human Mesenchymal Stem Cells with Enhanced Proangiogenic Activity Promotes Neovascularization and Ischemic Limb Salvage in Mice

    Researchers investigated the effects of rapamycin on the proangiogenic ability of senescent human umbilical cord mesenchymal stem cells.
    [Acta Pharmacologica Sinica]

    Abstract

    Poly(I:C) Enhances Mesenchymal Stem Cell Control of Myeloid Cells From COVID-19 Patients

    The authors hypothesized that viral mimic-priming improved mesnchymal stem cells’ abilities to rebalance the dysregulated immune responses in COVID-19.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Psoriasis-Like Dermatitis by Suppressing IL-17-Producing γδ T Cells

    Human umbilical cord-derived mesenchymal stem cells were subcutaneously injected into mice with imiquimod-induced psoriasis-like skin inflammation to explore the feasibility of this cellular therapy.
    [Cell and Tissue Research]

    AbstractGraphical Abstract

    Bone Tissue Engineering Using 3D Silk Scaffolds and Human Dental Pulp Stromal Cells Epigenetic Reprogrammed with the Selective Histone Deacetylase Inhibitor MI192

    Scientists investigated the potential of using a selective histone deacetylase 2 and 3 inhibitor, MI192, to promote human dental pulp stromal cells bone-like tissue formation in vitro and in vivo within porous Bombyx Mori silk scaffolds.
    [Cell and Tissue Research]

    Full ArticleGraphical Abstract

    A Novel Renal Perivascular Mesenchymal Cell Subset Gives Rise to Fibroblasts Distinct from Classic Myofibroblasts

    The authors described a novel subset of renal perivascular mesenchymal stem cell that expressed Meflin, a glycosylphosphatidylinositol-anchored protein that was recently identified as a marker of fibroblasts essential for cardiac tissue repair.
    [Scientific Reports]

    Full Article

    Hyperacute Transplantation of Umbilical Cord Mesenchymal Stromal Cells in a Model of Severe Intracerebral Hemorrhage

    Wistar rats were randomly selected to receive an intravenous injection of human umbilical cord-mesenchymal stem cell or the vehicle one hour after a severe Intracerebral hemorrhage.
    [Future Science OA]

    Full Article
    Be sure the cells you’re gene editing are still HSPCs with StemSpan™ SFEM II culture medium.
    REVIEWS

    A Brief Overview of Global Trends in MSC-Based Cell Therapy

    Scientists summarize the biological effects and mechanisms of action of MSCs, elucidating recent clinical trials phases and findings, and highlighting therapeutic effects of mesenchymal stem cells in several representative diseases
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    Human Placenta-Derived Amniotic Epithelial Cells as a New Therapeutic Hope for COVID-19-Associated Acute Respiratory Distress Syndrome (ARDS) and Systemic Inflammation

    Investigators focus on the proposed early and late therapeutic mechanisms of human amniotic epithelial cells and their exosomes to injured organs.
    [Stem Cell Research & Therapy]

    Full ArticleGraphical Abstrac
    INDUSTRY AND POLICY NEWS

    Stem Cell Biotech Neuroplast Enrolls First Patient in Phase II Clinical Trial of Transformative Neuro-Cells® Treatment for Traumatic Spinal Cord Injury

    Neuroplast has enrolled its first patient in a Phase II clinical trial to evaluate efficacy of its transformative Neuro-Cells® treatment that aims to prevent further damage to the central nervous system after sustaining acute traumatic spinal cord injury.
    [Neuroplast]

    Press Release

    Athersys Reports That Its Partner, HEALIOS K.K., Provides Updates on MultiStem® Clinical Programs in Japan

    Athersys, Inc. announced that its partner, HEALIOS K.K. provided updates on its two clinical programs evaluating MultiStem® cell therapy, for which Healios has a license and is responsible for the development and commercialization of MultiStem for ischemic stroke and acute respiratory distress syndrome in Japan.
    [Athersys, Inc.]

    Press Release
    FEATURED EVENT

    European Immunogenetics and Histocompatibility Conference

    May 17 – 20, 2022
    Amsterdam, The Netherlands

    > See All Events

    JOB OPPORTUNITIES

    Research Scientist – Immuno Surveillance

    Francis Crick Institute – London, England, United Kingdom

    Postdoctoral Fellow Position – Translational Research

    Stanford University – Stanford, California, United States

    Science Writer – Blood Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Postdoctoral Fellow – CAR-T Cell Exhaustion in Solid Tumors

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Research Engineer – Bioprinted Tissue Therapeutics

    Aspect Biosystems – Vancouver, British Columbia, Canada

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Cell Therapy News Twitter