 | | Vol. 13.12 – 11 April, 2022 |
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| The authors demonstrated the induction of functional primordial germ cell-like cells (PGCLCs) from rat PSCs. They showed that epiblast-like cells in floating aggregates formed rat PGCLCs.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using an myogenic progenitor cell (MPC)-specific fluorescent reporter system, scientists demonstrated that hPSC-derived MPCs could contribute to the regeneration of myofibers in mice following local injury and in mice deficient of dystrophin.
[Cell Stem Cell] |
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| Researchers engineered simple-to-implement injectable hydrogels for the controlled co-delivery of CAR-T cells and stimulatory cytokines that improve treatment of solid tumors.
[Science Advances] |
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| A dual pH-responsive hydrogel with tumor acidity neutralizer and neutrophil extracellular traps lyase was developed and used in combination with natural killer cell infusion for preventing post-resection hepatocellular carcinom recurrence.
[Biomaterials] |
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| The authors developed an efficient and scalable protocol to produce hPSC-derived liver sinusoidal endothelial cells progenitors characterized as venous endothelial cells from different mesoderm subpopulations.
[Cell Reports] |
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| Since natural killer (NK)-92 cells do not spontaneously express CCR7, clinical-grade activated NK cells were transfected with a non-viral vector containing the CCR7 receptor, an anti-CD19 CAR and a high-affinity CD16 Fc receptor.
[Cytotherapy] |
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| Investigators tested the outcome after implantation of contractile engineered heart muscle and non-contractile engineered connective tissue as well as engineered mesenchymal tissue allografts as transmural heart wall replacement.
[Journal of Molecular and Cellular Cardiology] |
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| ‘SIAMMS II’ was a prospective, single centre Phase I extension study in which participants in the SIAMMS study were offered repeat bone marrow harvest and infusion of autologous, unfractionated bone marrow as a day-case procedure.
[Multiple Sclerosis and Related Disorders] |
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| Mesenchymal stem cells were encapsulated in the 3D printable GelMA ink, and their biological properties were assessed in vitro to evaluate their potential for cell delivery application.
[Journal of Biomedical Materials Research Part B-Applied Biomaterials] |
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| Based on current knowledge of trabecular meshwork pathology in glaucoma and existing literature regarding stem cell regeneration of this tissue, scientists propose a human clinical study as the next step in understanding this potentially revolutionary treatment paradigm.
[Progress in Retinal and Eye Research] |
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| The authors review the mitochondrial characteristics of exhausted T cells and particularly discuss different aspects of mitochondrial metabolism and plasticity.
[Journal of Hematology & Oncology] |
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| Artiva Biotherapeutics, Inc., an oncology company whose mission is to deliver highly effective, off-the-shelf, allogeneic natural killer cell therapies to treat cancer, announced that it has entered into an agreement with Merck, known as MSD outside the United States and Canada.
[Artiva Biotherapeutics, Inc.] |
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| A Japanese university research team has concluded that the world’s first clinical trial, spanning over years, transplanting corneal tissues derived from iPSC, or iPS cells, into four almost-blind patients was safe and effective.
[Kyodo News] |
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| May 11 – 15, 2022
Amsterdam, The Netherlands |
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| | Novo Nordisk – Fremont, California, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Stanford University – Stanford, California, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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