PUBLICATIONS (Ranked by impact factor of the journal) | A Human Disease Model of Drug Toxicity-Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice Researchers demonstrated the proof of principle for using a biomimetic microdevice that reconstitutes organ-level lung functions to create a human disease model-on-a-chip that mimics pulmonary edema. The microfluidic device, which reconstitutes the alveolar-capillary interface of the human lung, consists of channels lined by closely apposed layers of human pulmonary epithelial and endothelial cells that experience air and fluid flow, as well as cyclic mechanical strain to mimic normal breathing motions. [Sci Transl Med] Abstract | Press Release
Mechanism of Extravasation of Infused Regenerative Cells From Microvessels into Tissue Parenchyma Leukocytes invade tissue by diapedesis; stem cells are commonly assumed to do likewise, but evidence is lacking. In this study, cardiac-derived regenerative cells and multi-cellular cardiospheres were infused into the coronary vessels of rat hearts. Serial histology revealed a novel mechanism of cell transmigration, “active vascular expulsion”, which underlies the extravasation of infused cells and cell aggregates. [Stem Cells] Abstract
BMP4 Sufficiency to Induce Choroid Plexus Epithelial Fate from Embryonic Stem Cell-Derived Neuroepithelial Progenitors Scientists provide evidence for bone morphogenetic protein 4 (BMP4) sufficiency to induce choroid plexus epithelial cell (CPEC) fate from neural progenitors derived from mouse embryonic stem cells. In addition to molecular, cellular, and ultrastructural criteria, derived CPECs had functions that were indistinguishable from primary CPECs, including self-assembly into secretory vesicles and integration into endogenous choroid plexus epithelium following intraventricular injection. [J Neurosci] Abstract | Press Release Reduction of Pro-Tumorigenic Activity of Human Prostate Cancer-Associated Fibroblasts Using Dlk1 or SCUBE1 The authors set out to reduce the pro-tumorigenic activity of patient cancer-associated fibroblasts (CAFs) using the Dlk1 and SCUBE1 molecules that they had previously identified in prostate development. Their hypothesis was that mesenchymally expressed molecules might reduce CAF pro-tumorigenic activity, either directly or indirectly. [Dis Model Mech] Abstract | Press Release
Long Term Reparative Effects of Mesenchymal Stem Cell Therapy following Neonatal Hyperoxia-Induced Lung Injury Mesenchymal stem cell (MSC) therapy may prevent neonatal hyperoxia-induced lung injury (HILI). There is however no clear data on the therapeutic efficacy of MSC in established HILI, the duration of the reparative effects and the exact mechanisms of repair. Researchers aimed to evaluate whether the long term reparative effects of a single intra-tracheal dose of MSC or MSC-conditioned medium are comparable in established HILI. [Pediatr Res] Full Article
Efficient Non-Viral Gene Therapy with FasL and Del1 Fragments in Mice Researchers aimed to improve FasL gene therapy with a non-viral vector by taking advantage of the E3 and C1 domains of Del1 protein, which induces apoptosis and localizes to the extracellular matrix. Mouse explanted tumors derived from a human oral squamous cell carcinoma cell line, SCCKN, were treated with plasmids encoding FasL, E3C1, and a fusion of FasL and E3C1. [J Gene Med] Abstract
Asymmetric siRNA Targeting the bcl-2 Gene Inhibits the Proliferation of Cancer Cells In Vitro and In Vivo Researchers demonstrated that an asymmetric small interfering RNA (asiRNA) consisting of 17 base pair duplex region (17 bp asiRNA), 17 bp asiRNA-M2, with a proteolipid micelle delivery system can effectively suppress the growth of H22 and BGC 803 tumors in vivo. These results suggest that the chemically modified asiRNAs may have potential as an effective therapeutic approach for cancer gene therapy in the future. [Int J Oncol] Abstract
Physical Properties and In Vitro Evaluation of Collagen-Chitosan-Calcium Phosphate Microparticle-Based Scaffolds for Bone Tissue Regeneration Researchers compared collagen-chitosan-calcium phosphate microparticle-based scaffolds fused with glycolic acid to their counterparts without collagen in terms of degradation, cytocompatibility, porosity, and Young’s modulus. In general, scaffolds exhibited 23% porosity, 0.6-1.2 MPa Young’s modulus, 23% degradation over 4 weeks, and supported a four to seven fold increase in osteoblast cell number over 7 days in culture. [J Biomater Appl] Abstract
| SCIENCE NEWS | ZIOPHARM Oncology Presents Systemic, DNA/Cell Plasmid Therapy Showing Long-Term Persistence and Anti-Tumor Effects ZIOPHARM Oncology, Inc. announced results from a preclinical study demonstrating the long-term persistence and anti-tumor effects of a new synthetic biology approach (DNA/cell plasmid) to controlled protein production in vivo. [Press release from ZIOPHARM Oncology, Inc. discussing research presented at the EORTC-NCI-AACR International Conference on Molecular Targets and Cancer Therapeutics, Dublin] Press Release VistaGen Therapeutics and Duke University Announce Heart Tissue Engineering Progress VistaGen Therapeutics, Inc. and Duke University announced that results of their collaboration were presented. The presentation, entitled “Human embryonic stem cell-derived cardiac tissue patch with advanced structure and function,” highlighted the important synergistic interactions of VistaGen’s stem cell-derived human cardiomyocytes and Duke’s tissue engineering and analytical technologies. [Press release from VistaGen Therapeutics, Inc. discussing research presented at the American Heart Association 2012 Scientific Sessions, Los Angeles] Press Release Two Years Out, All Patients Receiving Autologous Stem Cell Therapy Show Sustained Improvement in Heart Function Researchers presented data from their groundbreaking research in the use of autologous adult stem cells with patients who had previous heart attacks. They report that after two years, all patients receiving the stem cell therapy show improvement in heart function. [Press release from the University of Louisville discussing research presented at the American Heart Association Scientific Sessions 2012 Meeting, Los Angeles] Press Release Preclinical Data Support Potential Combinations for Allovectin® with Emerging Immunotherapies Vical Incorporated announced the release of animal data at a melanoma conference documenting the benefits of combining the company’s Allovectin® immunotherapy with anti-CTLA-4, anti-PD-1, and anti-PD-L1 antibodies, which are emerging immunotherapies for metastatic melanoma. [Press release from Vical Incorporated discussing research presented at the 9th International Congress of the Society for Melanoma Research, Hollywood] Press Release | POLICY | Update on Stem Cell Therapy The Department of Health saw the necessity to cover regulations for Stem Cell therapy. Stem Cell therapy belongs to the category of Advanced Cell therapy which includes biologics and blood. [Department of Health, Republic of the Philippines] Press Release £20 Million Investment for UK Synthetic Biology Research In a move that could potentially revolutionize major UK industries and help us to meet serious social and environmental challenges, the Biotechnology and Biological Sciences Research Council has announced an unprecedented £20M worth of synthetic biology projects. [Biotechnology and Biological Sciences Research Council, United Kingdom] Press Release | BUSINESS | Angel Biotechnology Holdings plc – Manufacturing Contract for ReNeuron Drug Substance Angel Biotechnology Holdings plc announced the signing of a new contract with ReNeuron Group plc. This contract relates to the expansion of CTX cells, the production of a GMP Drug Substance batch and associated testing. The contract is scheduled for completion in the current financial year. [Angel Biotechnology Holdings plc] Press Release Wellcome Trust and MRC Invest £13 Million to Create a New National Stem Cell Resource The Wellcome Trust and Medical Research Council (MRC) announced a £12.75 million initiative to create a catalogue of high-quality adult stem cells, so-called ‘induced pluripotent stem cells’ (iPS cells). The initiative will provide a knowledge base to underpin the use of such cells in studying the effects of our genes on health and disease and lay the foundations to create a new iPS cell bank, providing a world-class resource for UK researchers. [Wellcome Trust] Press Release Cardiac Cell Therapy Phase III Trial to Treat Refractory Angina CryopraxisTM/CellPraxis® aims to start patient recruitment for its Phase III Refractory Angina Cell Therapy Brazilian arm clinical trial by the end of 2012 or early 2013. The phase IIA/B clinical trial study was completed in December 2011. These trials involved the use of a proprietary autologous stem cell formulation indicated for neoangiogeneses. [Business Wire] Press Release Tengion Issued Notice of Allowance for U.S. Patent Application Covering Renal Regeneration for its Neo-Kidney Augment™ Product Candidate Tengion, Inc. announced that the United States Patent and Trademark Office has issued a Notice of Allowance for U.S. Patent Application No. 12/617,721, titled “Isolated Renal Cells and Uses Thereof.” The application includes claims intended to protect important aspects of Tengion’s renal regenerative product candidate, the Neo-Kidney Augment™, for the treatment of advanced chronic kidney disease. [Tengion, Inc.] Press Release IntelliCell BioSciences Announces FDA Listing For Human Cells, Tissues, and Cellular Based Products IntelliCell BioSciences, Inc. announced that it has been notified according to the FDA validation registration number 3009842420, that its new facility located at 460 Park Avenue, New York, NY 10022 is now registered to recover, process, package, store, and label human cells and tissue products such as the IntelliCell autologous stromal vascular fraction cellular product. In the registration notification, FDA acknowledged that the IntelliCell process is to be covered under regulations for tissue products. [PR Newswire Association LLC] Press Release Healthpoint Biotherapeutics Introduces 5×7 Size Of OASIS® Ultra Tri-Layer Matrix Healthpoint Biotherapeutics announced the introduction of a 5 cm x 7 cm size of OASIS® Ultra Tri-Layer Matrix, a naturally-derived extracellular matrix (ECM) material formed from three layers of porcine small intestinal submucosa. The three-layer construct of ECM was designed to provide increased structure for difficult-to-heal and chronic wounds. [Healthpoint Biotherapeutics] Press Release Tissue Regeneration at Heart of New Institute The emerging field of tissue regeneration, which harnesses the power and healing potential of stem cells, is an area to which scientists around the world are turning their attention. One of the foremost leaders in this area, Mark Sussman from San Diego State University (SDSU), announced the opening of SDSU’s new Integrated Regenerative Research Institute to help advance this area of research in San Diego. [San Diego State University] Press Release Kansas City-Based Likarda Named Among World’s Top 50 New Ventures Competing in Global Entrepreneurship Week’s Startup Open Likarda, an early-stage animal health company and a spinoff of the University of Kansas Medical Center, is one of the world’s 50 most promising new companies chosen to compete in the Global Entrepreneurship Week’s Startup Open this Monday. Likarda’s primary product, 3D islet cell clusters known as Kanslets™, can be transplanted into animals to cure diabetes through a simple procedure as routine as neutering a pet. [PR Newswire Association LLC] Press Release Introducing a New ASGCT Forum for Publication of Methodology and Clinical Development in Gene, Cell, and Oligonucleotide Therapies Editors are thrilled to announce the establishment of a new Methods section in Molecular Therapy’s sibling journal, Molecular Therapy Nucleic Acids. The section will focus specifically on methodology and technology development in gene-, cell-, and oligonucleotide-based therapy as well as on clinical development studies essential for safely moving these techniques into the clinic. [Molecular Therapy] Press Release | JOB OPPORTUNITIES | Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)
Product Manager – Hematopoietic (STEMCELL Technologies, Inc.)
Product Quality Scientist (STEMCELL Technologies, Inc.)
Scientist – Endothelial Cell Research (STEMCELL Technologies, Inc.)
Research Technologist – Cell Separation (STEMCELL Technologies, Inc.)
Postdoctoral Position – Pathophysiology of Brain Tumors (UMR 6301 ISTCT)
Scientist, Postdoctoral and Research Associate Positions (University of Miami – Sylvester Comprehensive Cancer Center)
Postdoctoral Positions in Cell Biology, Biophysics and Neurobiology (University of Missouri – Kansas City)
Postdoctoral Fellow in Stem Cell Tissue Engineering (Stanford University School of Medicine)
Cell Therapy Researcher (Bioiberica SA)
Principal Investigator – Stem Cell and Cardiovascular Diseases (Heart Center, Second Affiliated Hospital, Zhejiang University School of Medicine)
Postdoctoral Position – Tumor Stem Cells (Cancer Institute of New Jersey)
Quality Assurance Manager (The University of Texas Medical School at Houston)
Experienced Researcher (Hebrew University of Jerusalem)
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