PUBLICATIONS (Ranked by impact factor of the journal) | RD3 Gene Delivery Restores Guanylate Cyclase Localization and Rescues Photoreceptors in the Rd3 Mouse Model of Leber Congenital Amaurosis 12 To investigate the role of RD3 in photoreceptors and explore gene therapy as a potential treatment for Leber Congenital Amaurosis 12, scientists delivered adeno-associated viral vector with a Y733F capsid mutation and containing the mouse Rd3 cDNA under the control of the human rhodopsin kinase promoter to photoreceptors of 14 day old Rb(11.13)4Bnr/J and In (5)30Rk/J strains of rd3 mice by subretinal injections. [Hum Mol Genet] Abstract
Recovery From Experimental Parkinsonism by Semaphorin-Guided Axonal Growth of Grafted Dopamine Neurons Scientists asked whether intranigral transplantation of dopamine (DA) neurons, combined with either degradation of chondroitin sulphate proteoglycans or with grafts of Semaphorin 3-expressing cells, towards the striatum, is effective in establishing a new nigrostriatal dopaminergic pathway in rats with unilateral depletion of DA neurons. They found depolarization-induced DA release in dorsal striatum, DA axonal projections from substantia nigra to striatum, and concomitant behavioral improvement in Semaphorin 3-treated animals. [Mol Ther] Abstract
Myeloid/Microglial Driven Autologous Hematopoietic Stem Cell Gene Therapy Corrects a Neuronopathiclysosomal Disease The authors previously demonstrated improved neuropathology in mucopolysaccharidosistype IIIA (MPSIIIA) mice using lentiviral vectors (LV) overexpressing N-sulfoglucosaminesulfohydrolase in wild type hematopoietic stem cell transplants (LV-HSCT), achieved via donor monocyte/microglial engraftment in the brain. However, neurological disease was not corrected using LV in autologous MPSIIIA HSCT. In this study, to improve brain expression via monocyte/microglial specificity, LV expressing eGFP under ubiquitous PGK, or myeloid-specific promoters were compared in transplanted HSCs. [Mol Ther] Abstract
Pericytes Derived from Adipose-Derived Stem Cells Protect against Retinal Vasculopathy Adipose-derived stem cells (ASCs) differentiate into pericytes, suggesting they may be useful as a protective and regenerative cellular therapy for retinal vascular disease. Researchers found that ASCs express pericyte-specific markers in vitro. When injected intravitreally into the murine eye subjected to oxygen-induced retinopathy, ASCs were capable of migrating to and integrating with the retinal vasculature. [PLoS One] Full Article | Press Release
Adult Bone Marrow Neural Crest Stem Cells and Mesenchymal Stem Cells Are Not Able to Replace Lost Neurons in Acute MPTP-Lesioned Mice Whereas the in vivo integration and differentiation of bone marrow stromal cells in neurons into the central nervous system is currently matter of debate, researchers report that once injected into the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-treated mice, pure populations of either bone marrow neural crest stem cells or mesenchymal stem cells survived only transiently into the lesioned brain. [PLoS One] Full Article
Systemic Treatment with Adipose-Derived Mesenchymal Stem Cells Ameliorates Clinical and Pathological Features in the Amyotrophic Lateral Sclerosis Murine Model Researchers assessed the efficacy of the systemic administration of adipose-derived mesenchymal stem cells (ASC), a previously untested stem cell population, in superoxide-dismutase 1 (SOD1)-mutant transgenic mice, the animal model of familial amyotrophic lateral sclerosis. The administration of ASC to SOD1-mutant mice at the clinical onset significantly delayed motor deterioration for four-six weeks, as shown by clinical and neurophysiological tests. [Neuroscience] Abstract
Cyclosporine-Assisted Adipose-Derived Mesenchymal Stem Cell Therapy to Mitigate Acute Kidney Ischemia-Reperfusion Injury Researchers tested the hypothesis that cyclosporine-supported syngeneic adipose-derived mesenchymal stem cell (ADMSC) therapy offered superior attenuation of acute ischemia-reperfusion (IR) kidney injury than either therapy alone. They concluded that combination therapy using cyclosporine-plus-ADMSCs offers improved protection against acute IR kidney injury. [Stem Cell Res Ther] Abstract | Full Article
Inflammatory Hypertrophic Cauda Equina following Intrathecal Neural Stem Cell Injection The authors describe a woman who presented with progressive bilateral leg pain, numbness, and gait difficulties. A prior stroke, macular degeneration, osteoarthritis, and depression, led her to receive intrathecal neural stem cell therapy overseas one year prior to onset of symptoms. Imaging showed marked enlargement of lumbosacral roots of the cauda equina, which was not seen prior to stem cell treatment. Electrodiagnostic studies confirmed chronic multiple lumbosacral radiculopathies. [Muscle Nerve] Abstract
| BUSINESS | Surgeons at Duke University Hospital Implant Bioengineered Vein In a first-of-its-kind operation in the United States, a team of doctors at Duke University Hospital helped create a bioengineered blood vessel and implanted it into the arm of a patient with end-stage kidney disease. The procedure, the first U.S. clinical trial to test the safety and effectiveness of the bioengineered blood vessel, is a milestone in the field of tissue engineering. [Duke University Health System] Press Release
Advancing Neuroscience: MRI Interventions, IMRIS and Tocagen Combine Technologies to Precisely Deliver Potential Cancer-Fighting Drug to Brain Tumors MRI Interventions, Inc. and IMRIS Inc. announced that a surgical team at a leading U.S. neuroscience institution has delivered the investigational gene therapy drug Toca 511 directly into a glioblastoma brain tumor using real-time intraoperative MRI guidance within an IMRIS VISIUS® Surgical Theatre. MRI Interventions’ ClearPoint® Neuro Intervention System served as the navigation platform and the ClearPoint SmartFlow® large-bore cannula as the vehicle for delivery of the therapeutic agent. [MRI Interventions, Inc.] Press Release
NeoStem’s Subsidiary, PCT, Enters Into a Manufacturing Agreement with ImmunoCellular Therapeutics, Ltd. for Dendritic Cell Vaccines Targeting Brain and Other Cancers NeoStem, Inc., its subsidiary, Progenitor Cell Therapy LLC (PCT), and ImmunoCellular Therapeutics, Ltd. (IMUC), a clinical-stage biotechnology company that is developing immune-based therapies for the treatment of brain and other cancers, announced the execution of a Services Agreement under which PCT will provide current good manufacturing practices manufacturing services to support research and development of IMUC’s ICT-121 cell therapy product candidate, a dendritic cell vaccine targeting CD133 cells. [NeoStem Inc.] Press Release
Cell Therapy Companies Make Strong Progress from October 2012 to March 2013 Amid Mixed Stock Market Sentiment During Q4 2012 and Q1 2013, the cell therapy industry made strong progress in translation and commercialization. Continued development of the companies included in a dedicated stock market index suggests emergence of this industry as a distinct healthcare sector. [Cell Stem Cell] Summary Sosei Announces Establishment of a Regenerative Medicine Fund Sosei Group announced at the meeting of the Board of Directors that it resolved to invest in the regenerative medicine fund run by the newly-established subsidiary Sosei Corporate Venture Capital (Sosei CVC). Sosei Group will pursue a new venture through Sosei CVC. [Sosei Co. Ltd.] Press Release Arcturus Therapeutics Raises $1.3 Million in Series Seed Funding Arcturus Therapeutics, Inc., an industry leader in RNAi technologies for the treatment of disease, announced it has raised $1.3 million in a seed funding round led by multiple high net-worth private investors from the United States and Canada. [Arcturus Therapeutics, Inc.] Press Release Allied’s CardioCel® $1.9M Grant from Commercialization Australia Allied Healthcare Group announced that Commercialization Australia will soon announce that Allied’s CardioCel® is the recipient of a $1.9M grant for the commercialization and launch of the groups lead regenerative tissue product CardioCel®. CardioCel® is the group’s lead regenerative tissue product for the repair and reconstruction of cardiovascular defects including repairing heart valves. [Allied Healthcare Group Ltd.] Press Release SanBio Announces FDA Clearance for the Initiation of a Phase I/IIa Clinical Trial Testing Their Cell Therapy Product, SB623, in Patients with Traumatic Brain Injury SanBio Inc. announced that the U.S. Food and Drug Administration (FDA) has approved their Investigational New Drug application for the use of SB623, a novel allogeneic stem cell therapy product, in patients suffering from traumatic brain injuries. This approval allows the company to proceed with a Phase I/IIa clinical trial testing the safety and feasibility of the therapy. The clinical trial is expected to be carried out at several major hospitals in the United States. [PR Newswire Association LLC] Press Release Key Mesenchymal Precurser Cell Patent Granted in Japan Mesoblast Limited announced that it has been granted a key patent by the Japanese Patent Office. Japanese patent number 5265190 provides Mesoblast with exclusive commercial rights in Japan through to September 2025 to all compositions-of-matter and uses of its Mesenchymal Precursor Cell (MPC) technology platform, irrespective of the MPC tissue source, including bone marrow, adipose, placenta, umbilical cord and dental pulp. [Mesoblast, Inc.] Press Release Pluristem to Receive Clinical-Hold Notice from the U.S. FDA Pluristem Therapeutics Inc. announced that it has received notification from the U.S. Food and Drug Administration (FDA) that its United States phase II Intermittent Claudication study (IND 15038) has been placed on clinical hold due to a serious allergic reaction in a case which required hospitalization. [Pluristem Therapeutics Inc.] Press Release | |
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