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TOP STORY |
Auto-Attraction of Neural Precursors and Their Neuronal Progeny Impairs Neuronal Migration Limited neuronal migration into host brain tissue is a key challenge in neural transplantation. Scientists found that one important mechanism underlying this phenomenon is an intrinsic chemotactic interaction between the grafted neural precursor cells and their neuronal progeny. [Nat Neurosci] Abstract | Press Release |
PUBLICATIONS ( Ranked by impact factor of the journal) |
Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment Scientists showed that disruption of the microbiota impairs the response of subcutaneous tumors to CpG-oligonucleotide immunotherapy and platinum chemotherapy. [Science] Abstract | Press Release Platelet-Targeted Gene Therapy with Human Factor VIII Establishes Hemostasis in Dogs with Hemophilia A Inhibition of Rac1 Activity by Controlled Release of NSC23766 from Chitosan Microspheres Effectively Ameliorates Osteoarthritis Development In Vivo Stem Cell Derived Endochondral Cartilage Stimulates Bone Healing by Tissue Transformation Evaluation of Engraftment and Immunological Tolerance after Reduced Intensity Conditioning in a Rhesus Hematopoietic Stem Cell Gene Therapy Model Suppression of the Immune System as a Critical Step for Bone Formation from Allogeneic Osteoprogenitors Implanted in Rats Intracavernous Delivery of Clonal Mesenchymal Stem Cells Restores Erectile Function in a Mouse Model of Cavernous Nerve Injury Progranulin, a Major Secreted Protein of Mouse Adipose-Derived Stem Cells, Inhibits Light-Induced Retinal Degeneration |
REVIEWS |
Stem Cells in Preclinical Spine Studies This review focuses on two important applications of stem cells in spinal surgery: spine fusion and the management of degenerative disc disease. [Spine J] Abstract Towards Reaching the Target: Clinical Application of Mesenchymal Stem Cell (MSC) for Diabetic Foot Ulcers (DFUs) Visit our reviews page to see a complete list of reviews in the cell, gene and immunotherapy research field. |
SCIENCE NEWS |
Long-Lasting Gene Therapy Benefits Advanced Heart Failure Patients Researchers report the long-term benefits of a single dose of their gene therapy AAV1/SERCA2a in advanced heart failure patients. [Press release from Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai discussing research presented at the American Heart Association Scientific Sessions 2013, Dallas] Press Release Bone Marrow Mononuclear Stem Cells Show No New Gains in Heart Function Says TIME Study |
POLICY |
European Parliament Approves Horizon 2020 Funding Plan The European Parliament has formally approved Horizon 2020, the European Union’s funding program for research and innovation for 2014 through 2020. This leaves one formal step to go before the program’s actual rollout. [ScienceInsider] Editorial Communist Party Takes Aim at Elite Scientists |
BUSINESS |
Project A.L.S. Announces Research Effort with Lilly Project A.L.S. announced an agreement with Eli Lilly and Company aimed at helping to accelerate the development of potential therapies for the neurodegenerative disease amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. [Project A.L.S.] Press Release Life Stem Genetics Announces Collaborative Agreement with American CryoStem Actinium Pharmaceuticals Announces Plans for Iomab™-B Phase III Pivotal Trial Following Meeting with FDA Alnylam Earns $7 Million Milestone Payment from Genzyme for Phase II Success with Patisiran (ALN-TTR02), an RNAi Therapeutic Targeting Transthyretin (TTR) for the Treatment of TTR-Mediated Amyloidosis (ATTR) ARMO BioSciences Initiates Phase I Clinical Trial of First-in-Class Cancer Immunotherapy Alliqua Receives License to Celgene Cellular Therapeutics Advanced Wound Care Products Leading Scientists Join BioResearch Open Access Editorial Board under Editor-in-Chief Robert Lanza Allergen Research Corporation Announces $17 Million Series A Financing Regeneus to Fast-Track Human Cells under New Japanese Laws New Japanese Regenerative Medicine Legislation and Commercial Opportunities for Stem Cell Products |
NIH |
Submission for OMB Review; 30-day Comment Request: Generic Clearance To Support Programs and Administrative Operations at the National Cancer Institute (NCI) (FR Doc No: 2013-28086) |
CBER |
Guidance for Industry: Preclinical Assessment of Investigational Cellular and Gene Therapy Products |
REGULATORY |
Food and Drug Administration (United States) |
EVENTS |
NEW 19th Congress of the European Hematology Association June 12-15, 2014 Milan, Italy Visit our events page to see a complete list of events in the cell, gene and immunotherapy community. |
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