 | | Vol. 25.09 – 1 April, 2024 |
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| In a humanized mouse model of Systemic Lupus Erythematosus, a single infusion of Fox19CAR-Tregs restricts autoantibody generation, delayed lymphopenia, and restored the human immune system composition in lymphoid organs, without detectable toxicity.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated the induction of CAR T cells into an immortal-like and functional state, termed TIF. The induction of CARTIF cells depended on the repression of two factors, BCOR and ZC3H12A, and required antigen or CAR tonic signaling.
[Journal Of Experimental Medicine] |
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| Researchers reported the first individual treatment with a fully human CD19 CAR-T cell therapy in two patients with progressive multiple sclerosis. CD19 CAR-T cell administration resulted in acceptable safety profiles for both patients.
[Med] |
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| Poly(lactic-co-glycolic acid) microparticles encapsulating the anti-inflammatory and anti-fibrotic drug dexamethasone were administered to macrophages in vitro, with uptake rates controlled by different loading regimes.
[Biomaterials] |
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| Scientists reviewed 21 clinical trials across 60 manuscripts that featured a Food and Drug Administration-approved CAR T-cell construct or one of its predecessors. They highlighted substantial variability and limited reporting of cytokine measurement platforms and panels used across CAR T-cell clinical trials.
[Molecular Therapy] |
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| Investigators analyzed outcomes of rabbit anti-thymocyte globulin vs. post-transplantation Cyclophosphamide prophylaxis in adult patients with hematologic malignancies undergoing peripheral blood allogeneic stem cell transplantations from 10/10 antigen-matched unrelated donors.
[Leukemia] |
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| The authors present a ROS-responsive biomimetic nanocomplex co-loaded with Geniposide and Emodin in nanoliposome particles for targeted atherosclerosis therapy.
[Journal Of Nanobiotechnology] |
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| Plycaprolactone/up-conversion nanoparticles/magnesium oxide composite scaffolds were prepared by electrospun based on the luminescence characteristics of up-conversion nanoparticles under near infrared excitation and the osteogenic ability of MgO.
[Colloids And Surfaces B-Biointerfaces] |
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| Researchers tested whether combining image-guided ionizing radiation with an oncolytic vaccinia virus could yield a better therapeutic response than either treatment alone.
[PLOS One] |
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| Investigators performed a systematic review and meta-analysis to gain an overview of what a role immunotherapy plays in the treatment of type 1 diabetes.
[Pharmacological Research] |
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| The authors explore the capacity of neural cell regeneration and examine the critical aspects of self-assembled peptides in neuroregeneration, including their biochemical composition, topology, mechanical behavior, conductivity, and degradability.
[Macromolecular Bioscience] |
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| Xcell Biosciences, Inc., an instrumentation company focused on cell and gene therapy applications, announced it has added new elements to its research collaboration agreement with Labcorp, a global leader of innovative and comprehensive laboratory services.
[Xcell Biosciences, Inc. (BusinessWire)] |
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| NEOGAP Therapeutic has secured nearly €500K in funding from Eurostars for a collaboration project with the French biotech company Okomera. NEOGAP is developing pTTL, a personalized cell therapy utilizing modified proteins to activate the immune system against cancer cells.
[ArticStartup] |
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| May 5 -8, 2024
Beaver Run Resort, Colorado, United States |
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| | Cellistic – Mont-Saint-Guibert, Belgium |
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| | University of Colorado – Aurora, Colorado, United States |
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| | University of Colorado – Aurora, Colorado, United States |
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| | University of Manitoba – Winnipeg City, Manitoba, Canada |
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| | University of Colorado – Aurora, Colorado, United States |
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