| TOP STORY | Novel Cancer Vaccine Approach for Brain Tumors Researchers have been working on a cancer vaccine that would extend that survival by activating the patient’s immune system to fight the brain tumor. A study drilled down to the cellular and molecular mechanisms behind the vaccine, paving the way for further development and refinement of this new experimental treatment. [Press release from the Thomas Jefferson University discussing online prepublication in Cancer Immunology, Immunotherapy] Press Release | Abstract | |
| SCIENCE NEWS | Study Comparing Opdivo (Nivolumab) to Chemotherapy in Treatment Naïve Advanced Melanoma Patients Marks First PD-1 Immune Checkpoint Inhibitor to Demonstrate a Survival Benefit in a Phase III Trial Bristol-Myers Squibb Company announced results from CheckMate-066, a Phase III randomized double blind study, comparing Opdivo, an investigational PD-1 immune checkpoint inhibitor, to the chemotherapy dacarbazine in patients with treatment naïve BRAF wild-type advanced melanoma. [Press release from Bristol-Myers Squibb Company discussing research presented at the Society for Melanoma Research 2014 International Congress, Zurich] Press Release Interim Update from Randomized Phase II ReACT Study of Rindopepimut in Recurrent Bevacizumab-Naive Glioblastoma Demonstrates Statistically Significant Survival Benefit Celldex Therapeutics, Inc. announced an interim update from the Phase II ReACT study of rindopepimut in EGFRvIII-positive glioblastoma. The ReACT results demonstrate clear signs of clinical activity in patients with recurrent glioblastoma, including groups both naïve and refractory to bevacizumab. [Press release from Celldex Therapeutics, Inc. discussing research presented at the 19th Annual Meeting of the Society for Neuro-Oncology, Miami] Press Release New Autism Study Safety Data Presented Cord Blood Registry® announced that Dr. Michael G. Chez will present data from the first ever FDA-registered study on the safety of autologous umbilical cord blood stem cells in treating autism. [Press release from Cord Blood Registry® discussing research presented at the Translational Neuroscience: Bridging the Gap Between Basic Research Discoveries and Clinical Applications Cell Symposium, Arlington] Press Release From our sponsor: Free wallchart from Nature Neuroscience – Neural Stem Cells. Request your copy. |
| POLICY | Outcry over Lost E.U. Science Adviser Post Statements of dismay poured in after Anne Glover, the first chief scientific adviser to the European Commission, confirmed that her post had “ceased to exist” along with the previous administration’s mandate. [ScienceInsider] Editorial China Predicted to Outspend the US on Science by 2020 China is on track to overtake the United States in research and development spending by the end of the decade, according to a report on the global state of research spending. Other developing and middle-income countries are also narrowing their gap with the United States, Europe and Japan, the document finds. [Nature News] Editorial |
| BUSINESS | Pfizer Forms Global Strategic Alliance with Merck KGaA, Germany, to Jointly Develop and Commercialize Anti-PD-L1 to Accelerate Presence in Immuno-Oncology Pfizer Inc. announced that it has entered into an agreement with Merck KGaA, Darmstadt, Germany, to jointly develop and commercialize MSB0010718C, an investigational anti-PD-L1 antibody currently in development by Merck KGaA as a potential treatment for multiple types of cancer. [Pfizer Inc.] Press Release Advaxis Submits Investigational New Drug Application for Phase I/II Study of ADXS-HPV and MedImmune’s MEDI4736 for the Treatment of HPV-Associated Cervical and Head & Neck Cancer Advaxis, Inc. announced that the Company has submitted an investigational new drug application to the United States Food and Drug Administration to conduct a Phase I/II study of ADXS-HPV alone or in combination with MedImmune’s investigational anti-PD-L1 immune checkpoint inhibitor, MEDI4736, for the treatment of advanced, recurrent or refractory human papillomavirus (HPV)-associated cervical cancer and HPV-associated head and neck cancer. [Advaxis, Inc.] Press Release Oncothyreon and Celldex Therapeutics Announce Initiation of Combination Immunotherapy Clinical Trial of ONT-10 and Varlilumab Oncothyreon Inc. and Celldex Therapeutics, Inc. announced that they have initiated a combined clinical trial of ONT-10 and varlilumab. ONT-10 is a therapeutic vaccine targeting the tumor-associated antigen MUC1. Varlilumab is a fully human monoclonal antibody that targets CD27, a critical molecule in the activation pathway of lymphocytes. [Oncothyreon Inc.] Press Release Stellar Biotechnologies and Araclon Biotech Sign Exclusive KLH Supply Agreement for Clinical Trials in Alzheimer’s Active Immunotherapies Stellar Biotechnologies, Inc. and Araclon Biotech SL announced that the companies have executed a definitive exclusive supply agreement to meet Araclon’s Phase II/III clinical trial requirements for Keyhole Limpet Hemocyanin (KLH) used in Araclon’s active immunotherapies against Alzheimer’s disease. [Stellar Biotechnologies, Inc.] Press Release Inovio Pharmaceuticals to Independently Develop Prostate Cancer Immunotherapy; Will Maintain Collaboration and License Agreement with Roche for Inovio’s Hepatitis B Immunotherapy Inovio Pharmaceuticals, Inc. announced the company and Roche have terminated their 2013 collaboration, option, and license agreement to co-develop INO-5150, Inovio’s DNA immunotherapy targeting prostate cancer, as well as their research collaboration in prostate cancer. [Inovio Pharmaceuticals, Inc.] Press Release Cell Source’s Megadose Drug Combination Receives Regulatory Approval in Italy to Commence Human Clinical Trials Cell Source, Inc. announced its Megadose Drug Combination has been cleared for human clinical trials in Italy. Cell Source’s proprietary Megadose Drug Combination is expected to increase bone marrow transplantation success and survival. [Cell Source, Inc. (PR Newswire Association LLC)] Press Release Ki-Bum Lee Patents Technology to Advance Stem Cell Therapeutics Ki-Bum Lee has developed patent-pending technology that may overcome one of the critical barriers to harnessing the full therapeutic potential of stem cells. Lee and colleagues at Rutgers and Kyoto University in Japan have invented a platform they call NanoScript, an important breakthrough for researchers in the area of gene expression. [Rutgers University] Press Release Pioneer Award Recipients Zelig Eshhar, PhD and Carl H. June, MD, PhD Honored for Their Research on T-Cell Engineering for Cancer Immunotherapy Zelig Eshhar, PhD and Carl H. June, MD, PhD are co-recipients of the Pioneer Award, recognized for lentiviral gene therapy clinical trials and for their leadership and contributions in engineering T-cells capable of targeting tumors with antibody-like specificity through the development of chimeric antigen receptors. [Mary Ann Liebert, Inc.] Press Release |
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