| Vol. 21.23 – 29 June, 2020 |
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| Investigators tested whether the inflammatory nature of oncolytic viruses and their ability to remodel the tumor microenvironment may help to recruit and potentiate the functionality of CAR T cells. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In vivo, scientists observed an increase in cell retention and vasculogenesis after treatment with Mybl2‐over‐expressing explant‐derived cells which improved heart function in infarcted recipient hearts. [Aging Cell] |
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| In rats with ventral root avulsion injuries, the authors combined timed glial cell line‐derived neurotrophic factor gene therapy delivered to the proximal nerve roots with the digestion of inhibitory CSPGs in the distal denervated nerve using sustained lentiviral‐mediated chondroitinase ABC enzyme expression. [FASEB Journal] |
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| Scientists showed that psVEGFR‐3 significantly diminished cell growth with and without added VEGF‐C in vitro, and significantly reduced primary tumor growth and tumor metastases to wide‐spectrum organs in vivo. [Cancer Science] |
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| Investigators evaluated the therapeutic effect of human umbilical cord MSCs and laser alone or combined on spinal cord injury. [Journal of Cellular Physiology] |
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| Researchers grafted microencapsulated umbilical cord Wharton Jelly‐derived adult mesenchymal stem cell/human pancreatic islet‐derived progenitor cell co‐aggregates into NOD/SCID mice, and observed an acquired ability of cells to produce and store hormones. [Diabetes-Metabolism Research and Reviews] |
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| Eye drops containing biocompatible non-viral vectors based on solid lipid nanoparticles as gene delivery systems to induce the expression of interleukin 10 (IL-10) were designed to address the treatment of corneal inflammation. [Pharmaceutics] |
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| Platelet recovery following autologous stem cell transplantation (ASCT) was affected by insufficient hematopoietic recovery at stem cell harvest, a need for repeated apheresis, and high fever early after ASCT, particularly when the amount of infused stem cells was insufficient. [Annals of Hematology] |
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| Researchers found that the co‑transplantation of tonsil‑derived mesenchymal stromal cells (T‑MSCs) with bone marrow‑derived cells (BMCs) accelerated the recovery of involuted thymuses in mice following partial pre‑bone marrow transplantation conditioning with busulfan‑cyclophosphamide treatment, possibly by inducing FMS‑like tyrosine kinase 3 ligand and fibroblast growth factor 7 production in T‑MSCs. [International Journal of Molecular Medicine] |
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| Substantial advances have been made in producing mature β-cells from human pluripotent stem cells that respond appropriately to dynamic changes in glucose concentrations in vitro and rapidly function in vivo following transplantation in mice. [Nature Reviews Endocrinology] |
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| Scientists summarize the research advances related to oncolytic viruses that express immunomodulatory transgenes, as well as potential treatment pitfalls in patients with malignant gliomas. [Cell Death & Disease] |
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| Avalon GloboCare Corp. announced it has successfully completed Phase I first-in-human clinical study of its leading Chimeric Antigen Receptor T-cell therapy candidate, AVA-001. [Avalon Globocare Corp.] |
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| Rocket Pharmaceuticals, Inc. announced that it has received clearance from the FDA for the company’s Investigational New Drug application for RP-L401. [Rocket Pharmaceuticals, Inc.] |
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| Lineage Cell Therapeutics, Inc. provided an update on OPC1, the company’s oligodendrocyte progenitor cell therapy for the treatment of acute spinal cord injury. [Lineage Cell Therapeutics, Inc.] |
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| August 17 – August 19 Virtual |
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| Genezen Laboratories – Indianapolis, Indiana, United States |
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| Genezen Laboratories – Indianapolis, Indiana, United States |
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| Gilbert Family Foundation – Detroit, Michigan, United States |
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| Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States |
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| Guangzhou Regenerative Medicine and Health Guangdong Laboratory – Guangzhou, China |
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