 | | Vol. 21.29 – 17 August, 2020 |
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| Scientists tested the hypothesis that inhibition of the soluble epoxide hydrolase (sEH) enzyme using sEH inhibitors to decrease inflammation and fibrosis in the host myocardium may increase the survival of the transplanted human induced pluripotent stem cell derived‐cardiomyocytes in a murine postmyocardial infarction model.
[Stem Cells Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated efficient brain-targeted delivery of apolipoprotein E 2 (ApoE2) encoding plasmid DNA using glucose transporter-1 targeted liposomes.
[Molecular Pharmaceutics] |
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| Using the Japanese transplant registry data, the outcomes of 59 aggressive NK-cell leukemia patients who underwent first allogeneic hematopoietic stem cell transplantation were analyzed. Twenty-nine patients received stem cells from cord blood, 18 from peripheral blood, and 12 from bone marrow.
[Bone Marrow Transplantation] |
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| The authors examined umbilical cord-derived mesenchymal stem cells labeled with superparamagnetic and ultrasmall superparamagnetic iron oxide in terms of cell functioning and imaging efficiency in vitro and in vivo.
[Scientific Reports] |
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| Researchers determined if the combination of sevoflurane and adipose-derived stromal cells exerted additional protective effects against acute lung injury induced by cecal ligation and puncture in rats.
[Scientific Reports] |
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| Investigators found that PKH26-labeled human amniotic epithelial cells mainly distributed in the basal layer of endometrium after transplantation.
[Stem Cells and Development] |
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| Researchers tested the ability of adeno-associated viral (AAV) vectors carrying the cDNA for BMP-2 to transduce human mesenchymal stem cells, produce BMP-2, and induce osteogenesis in vitro as compared with lentiviral gene therapy with a two-step transcriptional amplification system lentiviral vector.
[Gene Therapy] |
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| Scientists evaluated the adeno-associated virus 5 vector system for its capability to target the central nervous system via intrastriatal, intrathalamic or intracerebroventricular delivery routes in rats.
[Gene Therapy] |
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| The authors found that the different sites of extranodal involvement may affect response, overall survival, and progression-free survival in patients with relapsed or refractory non-Hodgkin lymphoma treated with anti-CD19 CAR-T cells.
[Frontiers of Medicine] |
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| Investigators discuss the recent advances in proangiogenic gene therapy for critical limb ischemia and DNA vaccine for hypertension.
[Hypertension] |
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| The authors explored the therapeutic potential of both mesenchymal stem cells and exosomes in mitigating the COVID-19 induced cytokine storm as well as promoting the regeneration of alveolar tissue, attributed to the intrinsic cytokines and growth factor present in the secretome.
[Human Cell] |
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| Abeona Therapeutics Inc. and Taysha Gene Therapies announced that they have entered into license and inventory purchase agreements for ABO-202, an adeno-associated virus gene therapy for CLN1 disease.
[Abeona Therapeutics Inc.] |
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| Kiadis Pharma N.V. announced a new research program, K-NK-ID101, that will focus on the development of K-NK cells as a treatment for COVID-19.
[Kiadis Pharma N.V.] |
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| Pluristem Therapeutics Inc. announced its subsidiary, Pluristem Ltd., has signed a non-binding Memorandum of Understanding (MOU) with the United Arab Emirates-based Abu Dhabi Stem Cells Center.
[Pluristem Therapeutics Inc.] |
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| November 2 – November 3
Virtual |
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| | Pennsylvania State University – Philadelphia, Pennsylvania, United States |
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| | Roswell Park Center for Immunotherapy – Buffalo, New York, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Nanyang Technological University – Singapore, Singapore |
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| | Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States |
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