Cell Therapy News Volume 21.34 | Sep 28 2020

May 12, 2022

CTN 21.34 | Sep 28 2020

Cell Therapy News by STEMCELL Technologies

Vol. 21.34 – 28 September, 2020

TOP STORY

BATF3 Programs CD8⁺ T Cell Memory

Investigators showed that BATF3 was expressed transiently within the first days after T cell priming and had long-lasting T cell–intrinsic effects.
[Nature Immunology]

Abstract

The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.

PUBLICATIONSRanked by the impact factor of the journal

LRP6 Downregulation Promotes Cardiomyocyte Proliferation and Heart Regeneration

Researchers investigated the role of lipoprotein receptor-related protein 6 (LRP6) in heart repair through regulation of cardiomyocyte proliferation. Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal, juvenile and adult mice.
[Cell Research]

Full Article

Efficacy of Anti-CD147 Chimeric Antigen Receptors Targeting Hepatocellular Carcinoma

The authors report that T and NK cells transduced with a chimeric antigen receptor that recognized the surface marker, CD147, also known as Basigin, can effectively kill various malignant hepatocellular carcinoma (HCC) cell lines in vitro, and HCC tumors in xenograft and patient-derived xenograft mouse models.
[Nature Communications]

Full Article

Human
T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction

Coculturing CD19-expressing β-like cells and CD19 CAR-T cells resulted in T cell-mediated β-like cell death with release of activated T cell cytokines.
[Cell Reports Medicine]

Full Article Graphical Abstract

Augmentation
of NK Cell Proliferation and Anti-Tumor Immunity by Transgenic Expression of Receptors for Erythropoietin or Thrombopoietin

To reduce or preclude the necessity for IL-2 use, scientists investigated whether genetic engineering of NK cells to express the erythropoietin receptor or thrombopoietin receptor could be used as a method to improve NK cell survival and function.
[Molecular Therapy]

Abstract Graphical Abstract

Morphology
of Tumor and Nontumor Tissue in Liver Resection Specimens for Hepatocellular Carcinoma following Nivolumab Therapy

Twelve patients were treated with nivolumab in the neoadjuvant setting, whereas eight were treated with nivolumab, usually along with other therapies, before undergoing liver transplantation.
[Modern Pathology]

Abstract

Reduced
Dose of Posttransplant Cyclophosphamide in HLA-Haploidentical Peripheral Blood Stem Cell Transplantation

Scientists conducted two consecutive prospective multicenter Phase II studies to evaluate the safety and efficacy of 80 mg/kg of PTCy in 137 patients who underwent HLA-haploidentical peripheral blood stem cell transplantation following reduced-intensity conditioning.
[Bone Marrow Transplantation]

Abstract

Translation
Elongation Factor 2 Depletion by siRNA in Mouse Liver Leads to mTOR-Independent Translational Upregulation of Ribosomal Protein Genes

Researchers demonstrated the feasibility of perturbing protein synthesis in a mouse liver by targeting translation elongation factor 2 with RNAi. They were able to achieve over 90% knockdown efficacy and maintain it for two weeks effectively slowing down the rate of translation elongation.
[Scientific Reports]

Full Article

A
Modified Human Myogenin Promoter That Is Highly Active in Alveolar Rhabdomyosarcoma

Investigators designed a suicide gene therapy by generating an ARMS-targeted promoter to drive the herpes simplex virus thymidine kinase suicide gene.
[Cancer Gene Therapy]

Full Article

REVIEWS

CAR T Cell Therapies for Patients with Multiple Myeloma

Scientists highlight potential future innovations that could enhance the efficacy and/or reduce the toxicities associated with CAR T cell therapies.
[Nature Reviews Clinical Oncology]

Abstract

Stem/Progenitor
Cell-Based Transplantation for Retinal Degeneration: A Review of Clinical Trials

The authors provide a comprehensive overview on the progression of clinical trials for retinal degeneration treatment using four types of stem/progenitor cell-based transplantation to replace degenerative retinal cells and/or to supplement trophic factors from the aspects of safety, effectiveness and their respective advantages and disadvantages.
[Cell Death & Disease]

Full Article

INDUSTRY AND POLICY NEWS

Papyrus
Therapeutics Inc. Signs Research Collaboration with Oxford Biomedica

Papyrus Therapeutics, Inc. and Oxford Biomedica plc announced the signing of a research collaboration agreement, which includes the assessment of the impact and therapeutic benefit of Papyrus’ PYTX-002, a potential first-in-class gene replacement therapy.
[Papyrus Therapeutics, Inc.(BusinessWire, Inc.)]

Press Release

Athenex
Announces FDA Allowance of IND Application for TCRT-ESO-A2, a TCR-T Cell Therapy

Athenex, Inc. announced that the FDA has allowed its Investigational New Drug application for TCRT-ESO-A2, an autologous T cell receptor-T cell therapy targeting solid tumors that are NY-ESO-1 positive in HLA-A*02:01 positive patients.
[Athenex, Inc.]

Press Release

Seelos
Therapeutics Announces Sponsored Research Agreement with Duke University for Gene Therapy Studies of SLS-004 in Parkinson’s Disease

Seelos Therapeutics, Inc. announced the signing of a Sponsored Research Agreement with Duke University to use the MPTP-induced Parkinson’s Disease (PD) mouse model to establish in vivo proof-of-concept study to demonstrate that administration of LV-dCas9-DNMT3A virus can prevent and/or delay PD and test the efficacy and safety of SLS-004.
[Seelos Therapeutics Inc.]

Press Release

FEATURED EVENT

BATF3 Programs CD8⁺ T Cell Memory

LRP6 Downregulation Promotes Cardiomyocyte Proliferation and Heart Regeneration

Efficacy of Anti-CD147 Chimeric Antigen Receptors Targeting Hepatocellular Carcinoma

Human
T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction

Augmentation
of NK Cell Proliferation and Anti-Tumor Immunity by Transgenic Expression of Receptors for Erythropoietin or Thrombopoietin

Morphology
of Tumor and Nontumor Tissue in Liver Resection Specimens for Hepatocellular Carcinoma following Nivolumab Therapy

Reduced
Dose of Posttransplant Cyclophosphamide in HLA-Haploidentical Peripheral Blood Stem Cell Transplantation

Translation
Elongation Factor 2 Depletion by siRNA in Mouse Liver Leads to mTOR-Independent Translational Upregulation of Ribosomal Protein Genes

A
Modified Human Myogenin Promoter That Is Highly Active in Alveolar Rhabdomyosarcoma

CAR T Cell Therapies for Patients with Multiple Myeloma

Stem/Progenitor
Cell-Based Transplantation for Retinal Degeneration: A Review of Clinical Trials

Papyrus
Therapeutics Inc. Signs Research Collaboration with Oxford Biomedica

Athenex
Announces FDA Allowance of IND Application for TCRT-ESO-A2, a TCR-T Cell Therapy

Seelos
Therapeutics Announces Sponsored Research Agreement with Duke University for Gene Therapy Studies of SLS-004 in Parkinson’s Disease

i-Vaccines 2021: International Vaccines & Virology Conference

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PhD
Student – Topical Gene Therapy

Research
Fellow Position – Neural Cell Therapy

Research
Positions – Cancer and Immunotherapy

Research Fellow – Multiple Myeloma

Postdoctoral Scholar – Biomedical Engineering in Regenerative Medicine

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