 | | Vol. 22.02 – 18 January, 2021 |
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| Scientists showed that chaperone-mediated autophagy 5, a selective form of lysosomal protein degradation, was involved in sustaining hematopoietic stem cell function in adult mice.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Antitumor activities, cytokine production, and proliferation were enhanced in decitabine-treated chimeric antigen receptor T cells both in vitro and in vivo.
[Nature Communications] |
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| Researchers analyzed the safety and evaluate preliminary efficacy of polyomavirus JC-specific T cell therapy in a cohort of hematological patients with Progressive Multifocal Leukoencephalopathy.
[Annals of Neurology] |
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| Investigators report increased frequencies of hematopoietic stem cell (HSC), HPC and lineage negative cells in the elderly but a decreased frequency of multi-lymphoid progenitors. Aged human HSCs further exhibited a delay in initiating division ex vivo though without changes in their division kinetics.
[Haematologica] |
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| The authors observed that transduced ribosomal protein S19 (Rps19)-deficient bone marrow cells could reconstitute mice long term and rescue the bone marrow failure and severe anemia observed in Rps19-deficient mice, with a low risk of mutagenesis and a highly polyclonal insertion site pattern.
[Haematologica] |
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| Scientists placed human retinal pigment epithelium (RPE) stem cell-derived RPE monolayers under the macula of a non-human primate model for three months.
[Stem Cell Reports] |
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| Researchers aimed at developing a gene therapy strategy for gene delivery into endothelial cells, the natural site of biosynthesis of Von Willebrand disease.
[Gene Therapy] |
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| The authors investigated the correlation between the gene polymorphisms within the HLA region and the adverse reactions of post-hematopoietic stem cell transplantation in patients with acute leukemia, where 72 patients were diagnosed with acute lymphocytic leukemia and 104 were acute myeloid leukemia.
[Scientific Reports] |
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| Scientists present an overview of nanomaterials that have been used to overcome clinical barriers to T-cell-based immunotherapies and provide their outlook of this emerging field at the interface of cancer immunotherapy and nanomaterial design.
[Nature Nanotechnology] |
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| The authors summarize the literature, provide an approach to better understanding of the possible etiology of immune mediated cytopenias, and propose a diagnostic and management plan for patients with inherited metabolic disorders who develop single or multi-lineage cytopenias after hematopoietic stem cell transplantation.
[Bone Marrow Transplantation] |
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| Adocia announced it has developed a hydrogel scaffold that hosts and protects pancreatic β cells for replacement of the missing cells of people with type 1 diabetes.
[Adocia] |
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| February 18, 2021
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | University of California San Francisco – San Francisco, California, United States |
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| | University of California, San Francisco – San Francisco, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States |
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