 | | Vol. 22.05 – 8 February, 2021 |
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| Chronic graft versus host disease (GvHD) manifestations in mice associated with high B cell-activating factor (BAFF)/B cell ratios and persistence of B cell receptor-activated B cells in peripheral blood and lesional tissue.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed an inhibitory feature, achieving a three-input logic, and demonstrated that this programmable system was functional in diverse adaptive and innate immune cells.
[Nature Communications] |
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| Scientists perform single cell genomic characterization of longitudinal samples from a patient who relapsed after initial CAR T cell treatment with lack of response to retreatment.
[Nature Communications] |
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| Investigators evaluated B7-H3 as a potential target for acute myeloid leukemia-directed CAR T cell therapy.
[Clinical Cancer Research] |
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| Researchers determined the precise role of miR-34a in mesenchymal stem cells exposed to hyperglycaemia and in recovery heart function after myocardial infarction in diabetes mellitus rats.
[Stem Cell Research & Therapy] |
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| Transplanted endothelial progenitor cells labelled with PKH26 were attached to the injured luminal surface the first day after balloon injury.
[Stem Cell Research & Therapy] |
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| scAAV1.tMCK.NT-3 was delivered to the gastrocnemius muscle of three-month-old Cx32 knockout mice. Measurable levels of neurotrophin-3 were found in the serum at six-month post gene delivery.
[Gene Therapy] |
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| In Sprague–Dawley rats, hindlimb ischemia was generated by femoral artery removal, then seven days after ischemic induction 1 × 105 SB623 cells or PBS was injected into the ischemic adductor muscle.
[Scientific Reports] |
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| The authors collected bone marrow stem cells derived exosomes to deal with spinal cord injury rats and LPS induced microglia to explore the possible mechanisms.
[Journal of Molecular Histology] |
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| Researchers demonstrated a practical, and widely applicable, approach that included the successful reprogramming of somatic cells from a patient with a urea cycle defect, their genetic correction and differentiation into hepatic organoids.
[International Journal of Molecular Sciences] |
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| In vivo, epithelial cell sheets were directly transplanted to skin defect models and histological examination was performed at one week postoperatively.
[BMC Biotechnology] |
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| State-of-the-art gene-editing technology has made it possible to repair the β-globin mutation in patient hematopoietic stem cells or target genetic loci associated with reactivation of endogenous γ-globin expression.
[Cell Stem Cell] |
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| The authors highlight advances in the development and application of gene-based therapies for neurodegenerative diseases and offer a prospective look into this emerging arena.
[Nature Neuroscience] |
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| Investigators discuss current approaches to disc regeneration, with a particular focus on cell-based therapeutic strategies, including ongoing challenges, and attempts to provide a framework to interpret current data and guide future investigational studies.
[Nature Reviews Rheumatology] |
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| Asklepios BioPharmaceutical, Inc. announced that the clinical team from Brain Neurotherapy Bio, Inc., a gene therapy company based in Columbus, Ohio, has joined AskBio to expand its clinical pipeline for the treatment of neurodegenerative disorders.
[Asklepios BioPharmaceutical, Inc.] |
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| March 1 – 3, 2021
Virtual |
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| | Max Planck Institute of Molecular Physiology – Dortmund, Germany |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | University of California San Francisco – San Francisco, California, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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