Cell Therapy News Volume 22.14 | Apr 19 2021

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    CTN 22.14 | Apr 19 2021


    Cell Therapy News by STEMCELL Technologies
    Vol. 22.14 – 19 April, 2021
    TOP STORY

    Chimeric Contribution of Human Extended Pluripotent Stem Cells to Monkey Embryos Ex Vivo

    Scientists studied the chimeric competency of human extended pluripotent stem cells in cynomolgus monkey embryos cultured ex vivo.
    [Cell]

    Full ArticlePress Release

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    PUBLICATIONSRanked by the impact factor of the journal

    A Nonviral, Nonintegrating DNA Nanovector Platform for the Safe, Rapid, and Persistent Manufacture of Recombinant T Cells

    The authors used nonintegrating minimally sized DNA vectors with an enhanced capability of generating genetically modified cells, and they demonstrated that they could be efficiently used to engineer human T lymphocytes.
    [Science Advances]

    Full Article

    Interleukin-11-Expressing Fibroblasts Have a Unique Gene Signature Correlated with Poor Prognosis of Colorectal Cancer

    To characterize IL-11+ cells in vivo, investigators generated Il11 reporter mice. IL-11+ cells appeared in the colon in murine tumor and acute colitis models.
    [Nature Communications]

    Full Article

    An Aged Bone Marrow Niche Restrains Rejuvenated Hematopoietic Stem Cells

    The authors determined the influence of an aged niche on the function of ex vivo rejuvenated old hematopoietic stem cells (HSCs), as the relative contribution of HSCs intrinsic mechanisms vs extrinsic mechanisms for aging of HSCs still remain unknown.
    [Stem Cells]

    Full Article

    Precision Modeling of Gall Bladder Cancer Patients in Mice Based on Orthotopic Implantation of Organoid-Derived Tumor Buds

    Scientists established a novel model using gall bladder organoids with mutant Kras and Trp53 loss generated in vitro by lentiviral Cre transduction and CRISPR/Cas9 gene editing.
    [Oncogenesis]

    Full Article

    Impact of Depth of Clinical Response on Outcomes of Acute Myeloid Leukemia Patients in First Complete Remission Who Undergo Allogeneic Hematopoietic Cell Transplantation

    Researchers examined the effect of depth of clinical response, including incomplete count recovery and/or measurable residual disease, in patients from the Center for International Blood and Marrow Transplantation Research registry.
    [Bone Marrow Transplantation]

    Abstract

    CRISPR/Cas9-Mediated Knockout of PIM3 Suppresses Tumorigenesis and Cancer Cell Stemness in Human Hepatoblastoma Cells

    Scientists used CRISPR/Cas9 gene editing with dual gRNAs to introduce large inactivating deletions in the PIM3 gene and achieve stable PIM3 knockout in the human hepatoblastoma cell line, HuH6.
    [Cancer Gene Therapy]

    Abstract

    CARAMBA: A First-in-Human Clinical Trial with SLAMF7 CAR-T Cells Prepared by Virus-Free Sleeping Beauty Gene Transfer to Treat Multiple Myeloma

    The CARAMBA clinical trial investigated the feasibility, safety, and anti-myeloma efficacy of autologous SLAMF7 CAR-T cells.
    [Gene Therapy]

    Full Article

    Survey results on the insights and hurdles of CRISPR genome editing.
    REVIEWS

    Vector Engineering, Strategies and Targets in Cancer Gene Therapy

    Scientists outline the advances and challenges in the field with emphasis on the biology and scope of vectors used for gene transfer, newer targets identified, and their outcome in preclinical and clinical studies.
    [Cancer Gene Therapy]

    Abstract

    INDUSTRY AND POLICY NEWS

    Agenus Doses First Cancer Patient with iNKT Cell Therapy

    Agenus, Inc. announced the dosing of the first cancer patient with agenT-797, an allogeneic iNKT cell therapy, in a Phase I clinical trial through its subsidiary, AgenTus Therapeutics.
    [Agenus, Inc. (Globe Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    Synthetic Biology: At the Crossroads of Genetic Engineering and Human Therapeutics

    May 3 – 4, 2021
    Virtual

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    JOB OPPORTUNITIES

    Research Associate – Cell and Tissue Mechanobiology

    King’s College London – London, England, United Kingdom

    Postdoctoral Fellow or Research Scientist – Cell and Gene Therapy of Cancer

    Rutgers University – New Brunswick, New Jersey, United States

    Postdoctoral Position – Gene and Cell Therapy Development for Treatment of Primary Immune Deficiencies

    NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States

    Lab Scientist – Tissue and Cellular Therapy

    The University of Iowa – Iowa City, Iowa, United States

    Assistant Professor – Hematology

    University of Washington – Seattle, Washington, United States

    > See All Jobs

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