 | | Vol. 22.15 – 26 April, 2021 |
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| Scientists present the composite outcomes of two pilot clinical trials of T cells bearing a 4-1BB-based, CD22-targeting CAR in patients with relapsed or refractory acute lymphoblastic leukemia.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that the release, through the implantation of a hyaluronic acid hydrogel, of CAR-T cells targeting the human chondroitin sulfate proteoglycan 4, polymer nanoparticles encapsulating the cytokine interleukin-15 and platelets conjugated with the checkpoint inhibitor programmed death-ligand 1 into the tumor cavity of mice with a resected subcutaneous melanoma tumour inhibits the local recurrence of the tumor.
[Nature Biomedical Engineering] |
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| The authors characterized the cellular properties and in vivo tissue repair activity of glial enriched progenitor cells differentiated from human-induced pluripotent stem cells.
[Science Translational Medicine] |
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| Scientists demonstrated successful genome editing in primary human islets using CRISPR and Cas9. They established a paradigm for genetic studies in human islet cells, and revealed regulatory and genetic mechanisms linking non-coding variants to human diabetes risk.
[Nature Communications] |
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| Investigators established a highly specific chimeric antigen receptors (CAR) against CD44v6 on head and neck squamous cell carcinoma cells that could be expressed on normal T-cells with lentiviral vectors.
[Oral Oncology] |
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| The authors showed restoration of visual function after transplantation of purified human pluripotent stem cell-derived cones into a mouse model of advanced degeneration.
[Cell Reports] |
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| Scientists investigated the therapeutic efficacy of mesenchymal stem cells for bronchopulmonary dysplasia in premature infants.
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| Researchers demonstrated that the established lacrimal gland (LG) organoids resembled the characteristics of normal LG tissue and may be used as a therapy for patients with dry eye disease.
[Stem Cell Research & Therapy] |
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| Investigators compared extracellular vesicles derived from multiple human mesenchymal stem cell and cardiosphere-derived cell donors using diverse in vitro and in vivo assays.
[Scientific Reports] |
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| Gene-edited SCD CD34+ cells contributed corrected cells 6 months post-xenograft mouse transplant without off-target δ-globin editing.
[Cell Reports Medicine] |
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| The authors discuss existing barriers and strategies to overcome them for successful T cell expansion and persistence in the context of adoptive T cell immunotherapy for solid cancers.
[Nature Reviews Immunology] |
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| Scientists provide an overview of the use of NK cells in cancer immunotherapy, their current status in clinical trials, as well as the design and implementation of delivery technologies.
[Cancer Gene Therapy] |
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| Vertex Pharmaceuticals, Inc. and Obsidian Therapeutics announced that the two companies have entered into a strategic research collaboration and licensing agreement focused on the discovery of novel therapies that regulate gene editing for the treatment of serious diseases.
[Vertex Pharmaceuticals, Inc.] |
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| LEXEO Therapeutics announced that the FDA has granted Fast Track designation to LX1001, the company’s adeno-associated virus mediated gene therapy program, for the potential treatment of apolipoprotein E4 associated Alzheimer’s disease.
[LEXEO Therapeutics] |
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| | LSU Health Science Center – Shreveport, Louisianam United States |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | The University of Iowa – Iowa City, Iowa, United States |
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| | University of Washington – Seattle, Washington, United States |
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