Scientists collected clinical histories of 13 patients with IL-21R deficiency from eight families across seven centers worldwide, including five novel patients identified by exome or NGS panel sequencing. [Journal of Clinical Immunology]
The authors demonstrated that human marrow‐derived MSCs were antimicrobial and anti‐inflammatory in vitro and in the context of an in vivo sustained infection of either Mycobacterium avium and/or Mycobacterium intracellulare. [Stem Cells Translational Medicine]
Investigators evaluatedchondrogenic differentiation potential of menstrual blood-derived mesenchymal stem/stromal cells (MSCs) and bone marrow MSCs stimulated with transforming growth factor β (TGF-β3) and activin A. [Stem Cell Research & Therapy]
Vascularized dental pulp stem cells (DPSC) constructs were fabricated by inducing endothelial differentiation, and then scientist investigated the behavior of differentiated DPSCs, the internal structure of cell constructs, and their pulp regenerative ability in vivo. [Journal of Dental Research]
Injectable alginate based microporous hydrogel were used to deliver 5-Azacytidine in zein protein nanoparticle with mesenchymal stem cells for attenuating adverse cardiac remodelling after myocardial infarction. [International Journal of Pharmaceutics]
12 patients with primary or secondary graft failure received T cell replete bone marrow grafts from haploidentical donors and post-transplantation cyclophosphamide. [Bone Marrow Transplantation]
Researchers described a non-genotoxic conditioning protocol using an immunotoxin targeting CD117 to achieve endogenous hematopoietic stem cell depletion and a cocktail of monoclonal antibodies to provide transient immune suppression against the transgene product in a murine hemophilia A gene therapy model. [Molecular Therapy-Methods & Clinical Development]
To evaluate donor‐derived functional sperm production after spermatogonial stem cells transplantation to adult monkeys that had received testicular irradiation during the prepubertal period. [Andrology]
The stellar successes of immunotherapies that harness the power of T cells to treat solid tumors and an improved understanding of the immune systems of patients with hematologic malignancies have led to major efforts to develop immunotherapies for the treatment of patients with AML. [Leukemia]
Despite their promising osteogenic properties, the clinical usefulness of recombinant bone morphogenetic protein is hindered by delivery problems that necessitate their application in vastly supraphysiological amounts. [Translational Research]
Investigators introduce neuropathic pain (NP) current pharmacological and nonpharmacological treatments, and preclinical studies of stem cells to treat NP. They also summarize stem cell mechanisms- including neuromodulation in treating NP. [International Journal of Molecular Sciences]
Two pharmaceutical companies have halted clinical trials of gene-targeting therapies for Huntington’s disease, following the drugs’ disappointing performance. [Nature News]
Off-the-shelf treatments for cancer made from genetically engineered T cells and natural killer, or NK, cells have each shown promise in clinical trials. Two biotech companies- Nkarta and CRISPR Therapeutics- announced a partnership that aims to merge the two immune-cell approaches together. [STAT News]
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