 | | Vol. 22.18 – 17 May, 2021 |
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| Scientists treated 50 patients with severe combined immunodeficiency due to adenosine deaminase (ADA) with an investigational gene therapy composed of autologous CD34+ hematopoietic stem and progenitor cells transduced ex vivo with a self-inactivating lentiviral vector encoding human ADA.
[New England Journal of Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported the generation of hypoimmunogenic cancer-antigen-specific T cells derived from induced pluripotent stem cells lacking β2-microglobulin, the class-II major histocompatibility complex transactivator and the natural killer cell-ligand poliovirus receptor CD155, and expressing single-chain MHC class-I antigen E.
[Nature Biomedical Engineering] |
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| The authors identified a population of Krt17+ basal cells with multipotent properties at the squamo-columnar anorectal junction that maintained a squamous epithelium during normal homeostasis and could participate in the repair of a glandular epithelium following tissue injury.
[Nature Communications] |
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| Scientists engineered red blood cells into artificial antigen-presenting cells presenting a peptide bound to the major histocompatibility complex I, the costimulatory ligand 4-1BBL, and interleukin-12.
[Nature Communications] |
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| The authors observed a high correlation in LILRB4 expression with other immune inhibitory receptors. After tumor challenge, LILRB4−/− mice and mice treated with anti-LILRB4 antibody showed reduced tumor burden and increased survival.
[Journal of Experimental Medicine] |
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| Analysis of CD45RA-depleted haploidentical mixed lymphocytes culture revealed insufficient suppression of alloresponses in the CD4+ compartment and identified CD276 as a marker for alloreactive memory Th1 T cells.
[Bone Marrow Transplantation] |
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| Investigators studied the role of serum‐derived small extracellular vesicles in diabetes mellitus–impaired microvascular endothelial cell function.
[Journal of the American Heart Association] |
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| High levels of FOXP3, CTLA4 and CD25 expression, demethylation of the FOXP3 promoter and high suppressive ability were found with no differences between Tregs and RA+Tregs.
[European Journal of Immunology] |
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| The Solupore system was used to deliver mRNA and CRISPR/Cas9 guide RNA ribonucleoprotein cargos to T cells, and efficiency was measured by flow cytometry.
[Cytotherapy] |
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| Investigators highlight the influence of hematopoeitic stem cells in the bone repair process, mainly through the promotion of osteogenesis and angiogenesis at the bone injury site.
[Tissue Engineering Part B-Reviews] |
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| Scientists summarize studies that indicate the superiority of IL-12 as a potential cytokine for conditioning T cells for adoptive cell therapy.
[Cancer Immunology Immunotherapy] |
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| BlueRock Therapeutics LP, FUJIFILM Cellular Dynamics, Inc., and Opsis Therapeutics, LLC announced that they have entered into a strategic research and development (R&D) alliance. As part of the alliance, the companies will combine their collective expertise to discover and develop off-the-shelf iPS cell therapies for ocular diseases.
[BlueRock Therapeutics LP] |
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| June 14 – 18, 2021
Virtual |
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| | University of California – Davis, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Stanford University – Stanford, California, United States |
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| | Zhejiang University – Zhejiang, China |
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Cancer Stem Cell News
Cell Therapy News
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Hepatic Cell News
Human Immunology News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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Pulmonary Cell News
