 | | Vol. 22.19 – 31 May, 2021 |
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| The authors demonstrated the feasibility of generating CD19-specific CAR19 T-cells from HLA-matched donors of sibling allogeneic hematopoietic stem cell transplant patients via a simple and inexpensive method using the piggyBac transposon.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported an example of injectable self-healing hydrogel based on gastric environment-adaptive supramolecular assembly, and explored its application for gastric perforation healing.
[ACS Nano] |
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| Investigators generated a herpes simplex 1-based oncolytic viruses expressing human IL-15/IL-15Rα sushi domain fusion protein, as well as off-the-shelf EGFR-CAR natural killer (NK) cells, and studied their monotherapy and combination efficacy in vitro and in multiple glioblastoma mouse models.
[Cancer Research] |
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| Scientists examined the abundance and butyrogenic capacity of butyrate producing bacteria in 28 healthy donors and 201 patients after allogeneic stem cell transplantation.
[Clinical infectious Diseases] |
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| Researchers analyzed the oxidative damage in models of liver injury characterized by biliary epithelial cells/hepatic progenitor cells (HPCs) activation and defined the impact of redox balance perturbation on HPC fate.
[NPJ Regenerative Medicine] |
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| Adropin in vitro reduced hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells (MSCs) and improved MSCs survival with increased phosphorylation of Akt and extracellular regulated protein kinases.
[Cell Death & Disease] |
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| Epothilone D could promote the neuronal differentiation of neural stem cells (NSCs) by upregulating Apol8, which might provide a promising therapeutic target for spinal cord injury repair.
[Stem Cell Research & Therapy] |
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| The authors investigated the immunosuppressive and immunomodulation abilities of Withaferin A and its effect on long-term islet allograft survival.
[Scientific Reports] |
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| Investigators described five Wolman disease patients diagnosed in infancy that were treated at Royal Manchester Children’s Hospital receiving enzyme replacement therapy with dietary substrate reduction then hematopoietic stem cell transplant — multimodal therapy.
[Orphanet Journal of Rare Diseases] |
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| The authors investigated whether functional reinnervation of denervated muscle could be achieved by early or delayed transplantation after denervation.
[Journal of Tissue Engineering and Regenerative Medicine] |
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| Scientists introduce CAR-T cell technology, describe the meaningful achievements of CAR-T cells observed in onco-hematology and discuss preliminary data obtained with CAR-T cells and their derivative constructions in experimental models of autoimmune diseases.
[Arthritis & Rheumatology] |
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| The authors present the history of CAR-T cell therapy, and then expand on various developments in the CAR ectodomain. They discuss different formats, each with their own advantages and disadvantages, as well as the developments in affinity tuning, avidity effects, epitope location, and influence of the extracellular spacer.
[Medicinal Research Reviews] |
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| GlycoMimetics, Inc. announced that clinicians at Washington University School of Medicine in St. Louis have dosed the first patient in an investigator-sponsored trial evaluating uproleselan as a prophylactic agent to reduce gastrointestinal toxicities associated with high-dose melphalan in autologous hematopoietic cell transplantation for multiple myeloma.
[GlycoMimetics, Inc.] |
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| Sorrento Therapeutics, Inc. announced receipt of clearance from the ANVISA to proceed with a Phase II Pivotal clinical trial of COVI-MSCâ„¢, an injectable infusion of MSCs, for the treatment of hospitalized COVID-19 patients suffering from acute respiratory distress syndrome.
[Sorrento Therapeutics, Inc.] |
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| July 13 – 15, 2021
Virtual |
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| | Cedars Sinai – Los Angeles, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Stanford University – Stanford, California, United States |
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| | Zhejiang University – Zhejiang, China |
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Cancer Stem Cell News
Cell Therapy News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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