 | | Vol. 22.21 – 14 June, 2021 |
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| The authors examined the safety and efficacy of human umbilical cord mesenchymal stem cell infusion for immune non-responder patients with chronic HIV-1 infection, who represented an unmet medical need even in the era of efficient antiretroviral therapy.
[Signal Transduction and Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists observed monoamine oxidase A (MAO-A) induction in mouse and human tumor-associated macrophages (tAMs). MAO-A-deficient mice exhibit decreased TAM immunosuppressive functions corresponding with enhanced antitumor immunity.
[Nature Communications] |
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| Researchers performed an integrative analysis of the mutational and transcriptional profiles of large cohorts of non-small-cell lung cancer patients and found that epigenetic downregulation of B2M was common.
[Immunology] |
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| Scientists conducted dual tumor and T-cell imaging by use of a bioluminescent reporter and positron emission tomography in clinically relevant mouse models of pleural mesothelioma and non-small cell lung cancer.
[Molecular Therapy-Oncolytics] |
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| The authors examined the potency and functionality of both female and male adipose derived mesenchymal stem cells in order to gain further insights into donor selection.
[Scientific Reports] |
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| Human articular chondrocytes and immortalised mesenchymal cells differentiated in chondrocytes were cultured in round-bottom 96-well plates to produce multicellular spheroids and their growth kinetics and viability was evaluated over seven days of culture.
[Tissue Engineering Part A] |
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| Immunohistochemistry and flow cytometry were performed to detect the characteristics of sialic acid-binding immunoglobulin-like lectin 10high (Siglec-10hi) tumor-associated macrophages and explored their impact on the tumor microenvironment of hepatocellular carcinoma.
[Experimental Hematology & Oncology] |
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| IL1β priming Tonsil-derived MSCs had an enhanced osteogenic differentiation and secreted factors that regulated both osteoclastogenesis and osteoblastogenesis.
[Tissue Engineering and Regenerative Medicine] |
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| Investigators investigated whether human endometrium-derived stem cells could be used for cardiac repair after ischemic injury and their possible underlying mechanisms.
[Current Stem Cell Research & Therapy] |
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| Investigators summarize the potential mechanisms and therapeutic effects of MSC-derived exosomes in cardiac regeneration and repair and provide evidence to support their clinical application.
[Stem Cell Reports] |
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| The authors summarize the emerging understanding of apoptosis in mediating mesenchymal stem cell transplant, highlighting the potential of apoptotic extracellular vesicles as cell-free therapeutics.
[Cell Death & Disease] |
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| Scientists discuss the progress made in iPSC-derived T cells and provides a roadmap for the development of CAR iPSC-derived T cells and off-the-shelf T-iPSCs.
[Pharmaceutical Research] |
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| IN8bio, Inc. announced an update from the ongoing Phase I clinical trial of INB-200, its DeltEx drug resistant immunotherapy , MGMT-gene modified gamma delta T-cells in patients with newly diagnosed GBM.
[IN8bio, Inc.] |
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| Notch Therapeutics is a Canadian company with a potential breakthrough in the form of a cost-effective and reliable manufacturing platform called Engineered Thymic Niche. The technology can create universally compatible T-cells from donor stem cells on an industrial scale, offering an efficient way to mass manufacture T-cell therapies that are of consistent quality.
[Notch Therapeutics] |
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| The National Institutes of Health (NIH) awarded Lydia Kavraki, PhD, of Rice University’s Brown School of Engineering, a U01 grant to develop a new approach to model and analyze protein-ligand interactions in cancer research. The end goal is to create a proteomics toolkit, PROTEAN-CR, focused on the structural analysis of protein-ligand interactions.
[Genetic Engineering & Biotechnology News] |
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| With a view to team science, the programme ZonMw Open Competition is specifically aimed at innovative and groundbreaking combinations of two or more research groups.
[ZonMw] |
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| July 12 – 15, 2021
Virtual |
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| | GSK – San Francisco, California, United States |
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| | Sana Biotechnology – Multiple Locations, United States |
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| | Shanghai Immune Therapy Institute – Shanghai, China |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | Cedars Sinai – Los Angeles, California, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
