 | | Vol. 22.22 – 21 June, 2021 |
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| Researchers investigated the impact of inhibiting HIF-1α transcriptional activity on cytotoxic immune cell infiltration into B16-F10 melanoma.
[Oncogene] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators described elevated infiltration by regulatory T cells as the most common feature, while other lymphocyte subsets and also expression of immune-regulatory molecules on tumor-infiltrating lymphocytes showed site-specific variation.
[npj Precision Oncology] |
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| The authors elucidated the role of ovarian cancer microenvironment in regulating the immunosuppressive function of CD11b+Gr1+ myeloid cells.
[Molecular Metabolism] |
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| Germ cell ablation downregulated the expression of glial cell line-derived neurotrophic factor, which has been shown to attract spermatogonial stem cells (SSCs) to niches, implying that nonablated niches would attract SSCs more efficiently.
[Stem Cell Reports] |
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| Orthotopic and ectopic hepatocellular carcinoma models were constructed by implanting Hepa1-6 cells at different body sites of mice. Immune agents were administrated via three ways, including intratumoral injection into one site of the tumor, intraperitoneal injection, and subcutaneous injection.
[Journal of Hepatocellular Carcinoma] |
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| The authors investigated whether bone marrow-derived cells (BMDCs) could be applied as gene carriers for cell-based gene therapy by employing the accumulation of BMDCs.
[Scientific Reports] |
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| Experiments in a mouse xenograft model using allo lymphocytes showed that PTPN3 inhibition in small cell lung cancer cells enhanced the anti-tumor effect of phosphatase non-receptor type 3 (PTPN3)-suppressed activated lymphocytes.
[Translational Oncology] |
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| The authors generated a rat xenotransplantation model to prove the role of macrophages as a xenotransplantation barrier. Immunodeficiency in SRG rats, which were Sprague–Dawley rats lacking Rag2 and Il2rg, was confirmed by flow cytometry and spleen immunostaining.
[Xenotransplantation] |
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| Scientists used 89Zr-Df-IAB22M2C, a human CD8-specific minibody to monitor CD8+ T cell infiltration into tumors by positron emission tomography.
[Molecular Imaging and Biology] |
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| The author provides background information on hirschsprung (HSCR) disease, outlines the future approaches of stem cell-based HSCR therapy, reviews recent key publications, discusses technical and ethical challenges the field faces prior to clinical translation, and tackles such challenges by proposing solutions and evaluating existing approaches to progress further.
[Gene Therapy] |
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| Lineage Cell Therapeutics, Inc. a biotechnology company developing allogeneic cell therapies for unmet medical needs, announced it granted an exclusive option to Amasa Therapeutics, Inc., to acquire an exclusive, royalty-bearing license to use Lineage’s HyStem technology for the development and commercialization of therapies for local treatment of solid tumors under pre-negotiated terms.
[Lineage Cell Therapeutics, Inc.] |
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| Essent Biologics™ has announced the launch of its human MSCs for regenerative medicine, biopharmaceutical and cell therapy research. Essent Biologics will provide highly-characterized, low-passaged human MSCs.
[Essent Biologics] |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | Institute of Oncology Research – Bellinzona, Switzerland |
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| | Shanghai Immune Therapy Institute – Shanghai, China |
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| | Sana Biotechnology – Multiple Locations, United States |
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| | Shanghai Immune Therapy Institute – Shanghai, China |
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