Cell Therapy News Volume 22.25 | Jul 12 2021

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    2021-07-12 | CTN 22.25


    Cell Therapy News by STEMCELL Technologies
    Vol. 22.25 – 12 July, 2021
    TOP STORY

    Locoregional Infusion of HER2-Specific CAR T Cells in Children and Young Adults with Recurrent or Refractory CNS Tumors: An Interim Analysis

    Researchers showed that engineering of a medium-length CAR spacer enhanced the therapeutic efficacy of human erb-b2 receptor tyrosine kinase 2 (HER2)-specific CAR T cells in an orthotopic xenograft medulloblastoma model.
    [Nature Medicine]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Genome-Scale Screens Identify Factors Regulating Tumor Cell Responses to Natural Killer Cells

    Scientists quantified the natural killer (NK) cell responsiveness of hundreds of molecularly annotated ‘DNA-barcoded’ solid tumor cell lines in multiplexed format and applied genome-scale CRISPR-based gene-editing screens in several solid tumor cell lines, to functionally interrogate which genes in tumor cells regulated the response to NK cells.

    [Nature Genetics]

    Abstract

    Gene Therapy for Aromatic L-Amino Acid Decarboxylase Deficiency by MR-Guided Direct Delivery of AAV2-AADC to Midbrain Dopaminergic Neurons

    The authors investigated the safety and efficacy of delivery of a viral vector expressing aromatic L-amino acid decarboxylase (AADC) (AAV2-hAADC) to the midbrain in children with AADC deficiency.
    [Nature Communications]

    Full Article

    Hypoimmune Induced Pluripotent Stem Cell–Derived Cell Therapeutics Treat Cardiovascular and Pulmonary Diseases in Immunocompetent Allogeneic Mice

    Investigators showed that gene-edited, immune-evasive cell grafts could survive and successfully treat diseases in immunocompetent, fully allogeneic recipients. A mixture of endothelial cells and cardiomyocytes was injected into infarcted mouse hearts, and both cell types orthotopically engrafted in the ischemic areas.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Incorporation of Bacterial Immunoevasins to Protect Cell Therapies from Host Antibody-Mediated Immune Rejection

    IdeS cleavage of host IgG averted Fc-dependent phagocytosis and lysis, and the residual F(ab’)2 fragments remained on the surface, providing cells with an inert shield from additional IgG deposition.
    [Molecular Therapy]

    Abstract

    The Post-Transplant Scoring System (PTSS) Is Associated with Outcomes in Patients with MDS after CD34+selected Allogeneic Stem Cell Transplant

    The authors investigated the prognostic value of the PTSS in a cohort of patients with myelodysplastic syndrome (MDS) who underwent myeloablative CD34-selected T-cell depletion transplants.
    [Bone Marrow Transplantation]

    Full Article

    Hematopoietic Stem Cell Transplantation in Children and Adolescents with GATA2-Related Myelodysplastic Syndrome

    Researchers analyzed the outcome of 65 patients reported to the registry of the European Working Group of myelodysplastic syndrome in childhood carrying a germline GATA2 mutation who had undergone hematopoietic stem cell transplantation.
    [Bone Marrow Transplantation]

    Full Article

    Effects of Stem Cells from Inducible Brown Adipose Tissue on Diet-Induced Obesity in Mice

    Scientists isolated and characterized adipose-derived mesenchymal stem cells from the visceral adipose tissue surrounding a pheochromocytoma, a model of inducible brown adipose tissue in humans.
    [Scientific Reports]

    Full Article

    Early Modifications of the Gut Microbiome in Children with Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation

    Researchers conducted a retrospective case–control study in allo-hematopoietic stem cell transplantation pediatric patients developing or not hepatic sinusoidal obstruction syndrome and profiled their gut microbiome over time, from before the transplant up to 72 days after.
    [Scientific Reports]

    Full Article

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    REVIEWS

    A Comparison of Chimeric Antigen Receptors Containing CD28 versus 4–1BB Costimulatory Domains

    Scientists provide an overview of T cell costimulation by CD28 and 4-1BB and, using the available preclinical and clinical data, compare the efficacy and toxicity profiles associated with CARs containing either costimulatory domain.
    [Nature Reviews Clinical Oncology]

    Abstract

    Theranostic Cells: Emerging Clinical Applications of Synthetic Biology

    Ex vivo and in vivo cell-based biosensors and therapeutics have been developed to target a wide range of diseases including cancer, microbiome dysbiosis and autoimmune and metabolic diseases.
    [Nature Reviews Genetics]

    Full Article

    INDUSTRY AND POLICY NEWS

    Tevogen Bio Announces FDA Clearance of Investigational New Drug (IND) Application For its Cytotoxic T Cell Therapy for COVID-19

    Tevogen Bio, a clinical stage biotechnology company, announced that the US FDA has cleared its IND application for TVGN-489, Allogeneic COVID-19 Specific Cytotoxic T Lymphocytes, allowing Tevogen Bio to initiate clinical trial of its investigational COVID-19 treatment.
    [Tevogen Bio (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    6th World Congress of the Tissue Engineering and Regenerative Medicine International Society

    November 15 – 19, 2021
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    JOB OPPORTUNITIES

    PhD Student – Interaction between HSPCs and Their Bone Marrow Niche

    The Technical University of Munich – Munich, Germany

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    The Westmead Institute for Medical Research – Sydney, Australia

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    Heinrich Heine University Düsseldorf – Düsseldorf, Germany

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    University of Basel – Basel, Switzerland

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