 | | Vol. 22.26 – 19 July, 2021 |
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| In this open-label, single-arm Phase I/II trial, 87 patients with recurrent/refractory non-Hodgkin lymphoma received an infusion at doses of 0.5 × 106–8 × 106 TanCAR7 T cells per kilogram of body weight after conditioning chemotherapy.
[Leukemia] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists expanded SARS-CoV-2 T cells from the peripheral blood of COVID-19-recovered donors and non-exposed controls using different culture conditions.
[Cell Reports] |
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| Ligation of dexamethasone and glucocorticoid receptor on tumor cells activated the PI3K signaling pathway and upregulated serum glucocorticoid-inducible kinase 1 (SGK1) expression, and then increased the expression of connective tissue growth factor (CTGF) through Nedd4l-Smad2.
[Oncogene] |
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| Trophoblast glycoprotein-targeted cell sorting enriched FOXA2+LMX1A+ ventral mesencephalic dopaminergic (vmDA) precursors and helped attain efficient behavioral recovery of rodent Parkinson’s disease models with increased numbers of TH+, NURR1+, and PITX3+ vmDA neurons in the grafts.
[npj Parkinson’s Disease] |
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| Investigators evaluated bacterial and fungal composition of fecal microbiota at day zero of allogeneic hematopoietic cell transplantation.
[Mucosal Immunology] |
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| Researchers reported the development of carHLH in 14·8% of pediatric patients and young adults treated with CD19-specific CAR T-cell therapy with carHLH, occurring most commonly in those with high disease burden.
[British Journal of Haematology] |
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| Scientists assessed the safety and efficacy of injecting intravenous Wharton’s jelly-derived mesenchymal stem cells (MSCs) in patients with COVID-19 as a treatment. Five patients with severe COVID-19 were treated with Wharton’s jelly-derived mesenchymal stem cells.
[Stem Cell Research & Therapy] |
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| The authors investigated the pulmonary transplantation of macrophages transgenic for alpha-1 antitrypsin (AAT) as a potential therapy for AAT deficiency-associated lung pathology.
[Gene Therapy] |
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| Researchers showed an effective method for transplantation of adipose-derived mesenchymal stem cell spheroids onto skin wounds in order to efficiently cure refractory ulcers.
[Scientific Reports] |
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| The authors set up a new natural scaffold derived from a decellularized porcine mucoperiosteum, engineered by an innovative micro-perforation procedure based on Quantum Molecular Resonance and then subjected to in vitro recellularization with human bone marrow-derived mesenchymal stem cells.
[Scientific Reports] |
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| Scientists provide a rundown of the rapidly expanding toolbox for CRISPR-based diagnostics, in particular the various assays, preamplification strategies and readouts, and highlight their main applications in the sensing of a wide range of molecular targets relevant to human health.
[Nature Biomedical Engineering] |
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GC LabCell and GC Cell announced that they have entered into a definitive merger agreement to combine in an all-stock transaction. The transaction brings together highly complementary portfolios with a robust broad cell therapy R&D pipeline and cutting-edge manufacturing capabilities to accelerate growth and enhance value creation.
[GC LabCell (BusinessWire, Inc.)] |
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| August 12 – 14, 2021
Busan, South Korea |
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| | Aarhus University – Aarhus, Denmark |
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| | The Technical University of Munich – Munich, Germany |
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| | The Westmead Institute for Medical Research – Sydney, Australia |
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| | Heinrich Heine University Düsseldorf – Düsseldorf, Germany |
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| | University of Basel – Basel, Switzerland |
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