Cell Therapy News Volume 22.27 | Jul 26 2021

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    2021-07-26 | CTN 2.27


    Cell Therapy News by STEMCELL Technologies
    Vol. 2.27 – 26 July, 2021
    TOP STORY

    CAR T Cells with Dual Targeting of CD19 and CD22 in Adult Patients with Recurrent or Refractory B Cell Malignancies: A Phase I Trial

    10 of 16 patients with large B cell lymphoma with progressive disease after CAR19 treatment had absent or low CD19.
    [Nature Medicine]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Siglec-6 Is a Novel Target for CAR T-Cell Therapy in Acute Myeloid Leukemia (AML)

    Researchers introduced sialic-acid-binding immunoglobulin-like lectin (Siglec)-6 as a novel target for CAR T-cells in acute myeloid leukemia (AML) and found that Siglec-6 was prevalently expressed on AML cell lines and primary AML blasts, including the subpopulation of AML stem cells.
    [Blood]

    Abstract

    Core-Shell Hydrogel Microfiber-Expanded Pluripotent Stem Cell-Derived Lung Progenitors Applicable to Lung Reconstruction In Vivo

    The authors established an expansion system of hPSC-derived lung progenitors based on their 3D culture in core-shell hydrogel microfibers, that ensured the maintenance of their bipotency for differentiation into alveolar and airway epithelial cells including alveolar type II cells.
    [Biomaterials]

    Full Article

    Characterization of Neoantigen-Specific T Cells in Cancer Resistant to Immune Checkpoint Therapies

    Leveraging the use of mass cytometry combined with multiplex major histocompatibility complex class I tetramer staining, researchers screened and identified tumor neoantigen–specific CD8+ T cells in the Lewis Lung carcinoma tumor model.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    A Universal Gene Correction Approach for FKRP-Associated Dystroglycanopathies to Enable Autologous Cell Therapy

    Investigators developed a gene-editing approach that replaced the entire mutant open reading frame with the wild-type sequence to universally correct all fukutin-related protein (FKRP) mutations and applied this approach to correct FKRP mutations in iPSCs derived from patients displaying broad clinical severity.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Localized Chemotherapy Based on Injectable Hydrogel Boosts the Antitumor Activity of Adoptively Transferred T Lymphocytes In Vivo

    A preprocessing strategy was developed to reprogram the immunosuppressive tumor microenvironment using a thermoresponsive hydrogel loaded with doxorubicin.
    [Advanced Healthcare Materials]

    Abstract

    Synthetic Multiepitope Neoantigen DNA Vaccine for Personalized Cancer Immunotherapy

    A DNA vaccine was efficiently uptaken by dendritic cells and induced effective immune response against mouse melanoma cells, leading to significant inhibition of melanoma tumor growth and reduction of lung metastasis in a mouse model.
    [Nanomedicine-Nanotechnology Biology and Medicine]

    AbstractGraphical Abstract

    Lymphoid and Myeloid Immune Cell Reconstitution after Nicotinamide-Expanded Cord Blood Transplantation

    Investigators evaluated the immune reconstitution (IR) of patients receiving omidubicel grafts during the first six months post-transplant, as IR was critical for favorable outcomes of the procedure.
    [Bone Marrow Transplantation]

    Abstract

    Depletion of High-Content CD14+ Cells from Apheresis Products Is Critical for the Successful Transduction and Expansion of CAR T Cells during Large-Scale cGMP Manufacturing

    Scientists found that high CD14+ cell content posed a challenge for manufacturing CAR T cells especially in patients with non-Hodgkin’s lymphoma and multiple myeloma due to the non-specific phagocytosis of the magnetic beads used to activate CD3+ T cells.
    [Molecular Therapy-Methods & Clinical Development]

    Full ArticleGraphical Abstract
    Watch Video Recordings from the Nature Research Round Table on hPSC Quality
    REVIEWS

    High-Throughput and Single-Cell T Cell Receptor Sequencing Technologies

    The authors highlight advances in high-throughput sequencing technologies to identify T cell receptor sequences and describe how they have been applied to discover fundamental insights into T cell-mediated immunity.
    [Nature Methods]

    Abstract

    Bracing NK Cell Based Therapy to Relegate Pulmonary Inflammation in COVID-19

    Investigators discuss the possible use of natural killer (NK) cells cells as a therapeutic agent in view of preventing immunological harms of SARS-CoV-2 and the current challenges in advocating NK cell therapy for the same.
    [Heliyon]

    Full Article
    INDUSTRY AND POLICY NEWS

    FDA Gives Speedy Review to Bayer’s Parkinson’s Stem Cell Therapy

    Bayer subsidiary BlueRock Therapeutics has been granted a fast-track review by the FDA for DA01, its stem cell-based therapy for Parkinson’s disease which is currently in early-stage clinical testing.
    [PharmaPhorum]

    Press Release

    GC LabCell and GC Cell to Merge, Creating a Premier Cell Therapy Company

    GC LabCell and GC Cell announced that they have entered into a definitive merger agreement to combine in an all-stock transaction.
    [GC LabCell (BusinessWire, Inc.)]

    Press Release

    Ottawa Researchers Receive $8 Million to Find Answers on COVID Vaccines, Cancer

    Ottawa researchers have been awarded more than $8 million to lead four national studies in pursuit of answers about how well COVID-19 vaccines work in people with cancer and other health conditions.
    [Ottawa Citizen]

    Press Release
    FEATURED EVENT

    DGI German Society for Immunogenetics

    September 15 – 16, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Scholar – Immunology, Cancer Immunotherapy, and Protein Engineering

    University of California Irvine – Irvine, California, United States

    Postdoctoral Positions – Stem Cell-Based Therapy

    UCLA Jules Stein Eye Institute -Los Angeles, California, United States

    Postdoctoral Researcher – CRISPR/Cas9 and Hematopoietic Stem Cell Biology

    Aarhus University – Aarhus, Denmark

    PhD Student – Interaction between HSPCs and Their Bone Marrow Niche

    The Technical University of Munich – Munich, Germany

    PhD Student – Interaction between HSPCs and Their Bone Marrow Niche

    The Technical University of Munich – Munich, Germany

    > See All Jobs

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