 | | Vol. 2.28 – 9 August, 2021 |
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| In this single-center, Phase I trial, scientists administered anti-CD7 chimeric antigen receptor (CAR) T cells, manufactured from either previous stem-cell transplantation donors or new donors, to patients with relapsed or refractory T-cell acute lymphoblastic leukemia, in single infusions at doses of 5 × 105 or 1 × 106 cells per kilogram of body weight.
[Journal of Clinical Oncology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that protecting the endothelial glycocalyx in vascular allografts via the enzymatic ligation of immunosuppressive glycopolymers under cold-storage conditions attenuated the acute and chronic rejection of the grafts after transplantation in the absence of systemic immunosuppression.
[Nature Biomedical Engineering] |
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| Scientists isolated a broad range of promising TCRs targeting multiple antigens for treatment of B-cell malignancies. 28 target genes for B-cell malignancies were selected based on gene expression profiles.
[Molecular Therapy] |
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| In this Phase I/II clinical trial, the authors investigated the safety and efficacy of high doses of mb-IL21 ex vivo expanded donor-derived NK cells to decrease relapse in 25 patients with myeloid malignancies receiving haploidentical stem-cell transplantation.
[Leukemia] |
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| Investigators determined the ratio of patients whose synovial MSCs were transplanted clinically, to intensively investigate MSCs with trisomy 7 from a safety perspective, and to follow up the patients for five years after transplantation.
[Stem Cells Translational Medicine] |
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| To determine the function of umbilical cord blood (UCB)-MSCs, the authors examined and compared the therapeutic effects of UCB-MSCs and UCB-MSC-derived exosomes on skin healing in rats.
[Stem Cell Research & Therapy] |
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| Scientists compared the biological and functional characteristics of naïve MLpvNG2 cells with identical bone marrow-derived MSCs using in vitro and in vivo procedures.
[Stem Cell Research] |
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| Researchers evaluated intratracheal MSCs as an approach to treat an hyperoxia-induced bronchopulmonary dysplasia animal model and compared the therapeutic effects between amniotic fluid-, umbilical cord- and bone marrow-MSCs.
[Journal of Cellular and Molecular Medicine] |
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| The authors formed encapsulated, transplantable neuronal networks of regionally matched cervical spinal motor neurons, interneurons, and oligodendrocyte progenitor cells derived through trunk-biased neuromesodermal progenitors.
[iScience] |
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| Researchers investigated the comprehensive cytokine dynamics following endoscopic submucosal dissection in patients with oesophageal cancer.
[Scientific Reports] |
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| The authors review current approaches to sample processing and computational analysis regarding their application to translational cancer immunotherapy research.
[Cancer Cell] |
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| Investigators outlined how epigenetic modifications in CAR T cells can overcome barriers limiting CAR T cell effectiveness, particularly in immunosuppressive tumor microenvironments.
[Molecular Therapy] |
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| The University of Michigan Health C.S. Mott Children’s Hospital is among the first study sites to begin applying stem cell therapy to babies with single ventricle heart disease.
[Michigan Medicine] |
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| Kite, a Gilead Company and Appia Bio, Inc. announced a collaboration and license agreement to research and develop hematopoietic stem cells-derived cell therapies directed toward hematological malignancies.
[Kite, a Gilead Company] |
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| September 6 – 10, 2021
Virtual |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Incyte – Wilmington, Delaware, United States |
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| | University of California, San Francisco – San Francisco, California, United States |
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| | University of California Irvine – Irvine, California, United States |
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| | UCLA Jules Stein Eye Institute – Los Angeles, California, United States |
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