Cell Therapy News Volume 22.31 | Aug 30 2021

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    Justin.choi
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    2021-08-30 | CTN 22.31


    Cell Therapy News by STEMCELL Technologies
    Vol. 22.31 – 30 August, 2021
    TOP STORY

    The Immunostimulatory RNA RN7SL1 Enables CAR-T Cells to Enhance Autonomous and Endogenous Immune Function

    Investigators engineered CAR-T cells to deliver RN7SL1, an endogenous RNA that activates RIG-I/MDA5 signaling. RN7SL1 promoted expansion and effector-memory differentiation of CAR-T cells.
    [Cell]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Immunotherapy Combinations Overcome Resistance to Bispecific T Cell Engager Treatment in T Cell–Cold Solid Tumors

    Using an immunocompetent mouse model expressing a humanized CD3ε chain and bispecific T cell engager (BiTE) molecules directed against mouse CD19, mouse CLDN18.2, or human EPCAM antigens, researchers investigated the pharmacokinetic and pharmacodynamic parameters and immune correlates associated with BiTE efficacy across multiple syngeneic solid-tumor models.
    [Science Translational Medicine]

    Abstract

    CD7-Deleted Hematopoietic Stem Cells Can Restore Immunity after CAR T Cell Therapy

    To rescue T and NK cells after CD7-targeting CART, researchers created hematopoietic stem cells (HSCs) genetically deleted for CD7. CD7-KO HSCs were able to engraft immunodeficient mice and differentiate into T and NK cells lacking CD7 expression.
    [JCI Insight]

    Full ArticleGraphical Abstract

    Combining Bone Collagen Matrix with hUC-MSCs for Application to Alveolar Process Cleft in a Rabbit Model

    A rabbit alveolar process cleft model was established by removing the bone tissue from the left maxillary bone. 48 young Japanese white rabbits were divided into normal, control, material and mesenchymal stem cell groups.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    Serum-Free Medium and Hypoxic Preconditioning Synergistically Enhance the Therapeutic Effects of Mesenchymal Stem Cells on Experimental Renal Fibrosis

    Researchers examined whether serum-free medium and hypoxic preconditioning synergistically enhanced the therapeutic effects of mesenchymal stem cells on renal fibrosis in rats with ischemia-reperfusion injury.
    [Stem Cell Research & Therapy]

    Full Article

    Exosomes from Primed MSCs Can Educate Monocytes as a Cellular Therapy for Hematopoietic Acute Radiation Syndrome

    Human monocytes were educated by exosomes from lipopolysaccharide-primed mesenchymal stem cells (MSCs) and compared to monocytes educated by unprimed MSCs and uneducated monocytes to assess survival and clinical improvement in a xenogeneic mouse model of acute radiation syndrome.
    [Stem Cell Research & Therapy]

    Full Article

    Phagocytosis by Stroma Confounds Co-Culture Studies

    The authors showed that mesenchymal stromal cells from selected donors and NKTert, a stromal cell line, which is commonly used for co-culture studies with primary leukemia cells, extensively phagocytose apoptotic cells.
    [iScience]

    AbstractGraphical Abstract

    The Promise(s) of Mesenchymal Stem Cell Therapy in Averting Preclinical Diabetes: Lessons from In Vivo and In Vitro Model Systems

    Investigators showed that intramuscular injection of placental (P)-mesenchymal stem cells homed more towards the visceral site, restored HOMA-IR and glucose homeostasis in the WNIN/GR-Ob rats. P-MSC therapy was effective in re-establishing the dysregulated cytokines.
    [Scientific Reports]

    Full Article

    Effect of Warm Acupuncture Combined with Bone Marrow Mesenchymal Stem Cells Transplantation on Cartilage Tissue in Rabbit Knee Osteoarthritis

    The authors investigated the effect and underlying mechanism of warm acupuncture combined with bone marrow mesenchymal stem cells transplantation on cartilage tissue injury in rabbit knee osteoarthritis.
    [Evidence-Based Complementary and Alternative Medicine]

    Full Article

    Survey results on the insights and hurdles of CRISPR genome editing.
    REVIEWS

    Accelerating Vein-to-Vein Cell Therapy Workflows with New Bioanalytical Strategies

    Scientists offer a survey of recent biotechnological advances supporting enhanced and expedited biomanufacturing workflows for autologous and allogeneic cell therapies, ranging from novel genetic engineering techniques and cell sorting platforms to stem cells and tumor organoid models.
    [Current Opinion in Biotechnology]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    IGB Researchers Receive $2.2 Million NIH Grant to Develop Better In Vivo DNA-Editing Techniques

    The National Institutes of Health have awarded a $2.2 million grant to researchers at the Carl Woese Institute for Genomic Biology (IGB). The team includes bioengineering professors Pablo Perez-Pinera and Thomas Gaj, and Founder Professor of physics, Jun Song. This four-year grant will be used to develop more precise genome editing technologies for gene therapy applications.
    [University of Illinois Urbana-Champaign]

    Press Release

    UCLA Scientists Receive $1 Million Translational Award to Advance CAR T Cell Therapy for Rare Melanomas

    Scientists Dr. Cristina Puig-Saus and Dr. Daniel Shin from the UCLA Jonsson Comprehensive Cancer Center have received a $1 million Translational Research Award from the US Department of Defense Melanoma Research Program to help advance the use of chimeric antigen receptor, or CAR, T cell therapy as a treatment for people with acral, mucosal and uveal melanomas.
    [UCLA Newsroom]

    Press Release
    FEATURED EVENT

    CRISPR and Beyond: Perturbations at Scale to Understand Genomes

    September 22 – 25, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Faculty Position – Translational Immunology

    University of Miami – Miami, Florida, United States

    Senior Scientist – Immuno-Oncology

    Epitopea – Cambridge, England, United Kingdom

    Development Engineer – Cell Therapies and Regenerative Medicine

    Danaher – Toronto, Ontario, Canada

    Research Associate – Cell and Regenerative Biology

    University Of Wisconsin–Madison – Madison, Wisconsin, United States

    Postdoctoral Fellow – Bioprinting for Pancreas Biofabrication

    University Medical Center Utrecht – Utrecht, Netherlands

    > See All Jobs

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