Cell Therapy News Volume 22.33 | Sep 20 201

May 12, 2022

2021-09-33 | CTN 22.33

Cell Therapy News by STEMCELL Technologies

Vol. 22.33 – 20 September, 2021

TOP STORY

Harnessing Features of Adaptive NK Cells to Generate iPSC-Derived NK Cells for Enhanced Immunotherapy

Natural killer (NK) cells derived from uniformly engineered iPSCs, termed iADAPT, displayed metabolic features and gene expression profiles mirroring those of cytomegalovirus-induced adaptive NK cells.
[Cell Stem Cell]

Abstract Graphical Abstract

Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.

PUBLICATIONSRanked by the impact factor of the journal

A Randomized Phase II Trial of Idiotype Vaccination and Adoptive Autologous T Cell Transfer in Multiple Myeloma Patients

In this randomized, Phase II trial, eligible patients received either the control or idiotype-keyhole limpet hemocyanin vaccine, an auto-transplant, vaccine-specific co-stimulated T cells expanded ex vivo, and two booster doses of the assigned vaccine.
[Blood]

Abstract

Ectopic Activation of the miR-200c–EpCAM Axis Enhances Antitumor T Cell Responses in Models of Adoptive Cell Therapy

Investigators found that ectopic expression of microRNA-200c markedly enhanced the antitumor activity of CD8⁺ cytotoxic T lymphocytes during adoptive cell therapy in multiple mouse models.
[Science Translational Medicine]

Abstract

Biological Resurfacing in a Canine Model of Hip Osteoarthritis

Scientists used 3D weaving, additive manufacturing, and autologous mesenchymal stem cells to create a tissue-engineered, bicomponent implant to restore hip function in a canine hip osteoarthritis model.
[Science Advances]

Full Article

Three-Dimensional Covalent Organic Frameworks with Cross-Linked Pores for Efficient Cancer Immunotherapy

Mechanism studies revealed that after linking these immunogenic cell death inert monomers into the covalent organic frameworks (COFs) backbone, the optical properties of these COFs could be systematically tuned to achieve excellent reactive oxygen species production performance.
[Nano Letters]

Abstract Graphical Abstract

Combine and Conquer: Manganese Synergizing Anti-TGF-β/PD-L1 Bispecific Antibody YM101 to Overcome Immunotherapy Resistance in Non-Inflamed Cancers

The synergistic effect between Bivalent manganese and YM101 in vitro was determined by one-way mixed lymphocyte reaction, CFSE dilution assay, and cytokine detection.
[Journal of Hematology & Oncology]

Full Article

Mesenchymal Stromal Cells as Carriers of IL-12 Reduce Primary and Metastatic Tumors of Murine Melanoma

Researchers developed a system in which cytokine may be administered intravenously without toxic side effects. MSC were used as carriers of the IL-12.
[Scientific Reports]

Full Article

Effects of Single and Multiple Transplantations of Human Umbilical Cord Mesenchymal Stem Cells on the Recovery of Ovarian Function in the Treatment of Premature Ovarian Failure in Mice

Scientists compared the effect of single and multiple injections of human umbilical cord blood-MSCs on ovarian function repair in chemotherapy-induced premature ovarian failure.
[Journal of Ovarian Research]

Full Article

First-in-Human Clinical Trial of Transplantation of iPSC-Derived NS/PCs in Subacute Complete Spinal Cord Injury: Study Protocol

A clinical study used an open-label, single-arm design. The initial follow-up period will be one year. The primary objective was to assess the safety of human induced pluripotent stem cell-derived neural stem/progenitor cell transplantation in patients with subacute spinal-cord injury.
[Regenerative Therapy]

Abstract

Pharmacokinetically Guided, Once-Daily Intravenous Busulfan in Combination with Fludarabine for Elderly AML/MDS Patients as a Conditioning Regimen for Allogeneic Stem Cell Transplantation

The efficacy of pharmacokinetically guided, once-daily administration of busulfan was evaluated in elderly patients with acute myeloid leukemia/myelodysplastic syndrome.
[International Journal of Hematology]

Abstract

Evaluate the Presentation of Mutant KRAS Peptides on Individual HLA-I Molecules Using Targeted Mass Spectrometry and Identify 13 Unpublished KRASG12C/D/R/V Mutation/HLA-I Pairs and Nine Previously Described Pairs.

The authors evaluated the presentation of mutant KRAS peptides on individual HLA-I molecules using targeted mass spectrometry and identify 13 unpublished KRAS^G12C/D/R/V mutation/HLA-I pairs and nine previously described pairs.
[Cell Reports Methods]

Full Article

Mesenchymal Stem Cells Act as Stimulators of Neurogenesis and Synaptic Function in a Rat Model of Alzheimer’s Disease

The possible roles of human umbilical mesnchymal stromal cord and adipose mesenchymal stem cells in neurogenesis and synaptic function were investigated using a β-amyloid 1-42-induced Alzheimer’s disease rat model.
[Heliyon]

Full Article

Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes

REVIEWS

HSCT Remains the Only Cure for Patients with Transfusion-Dependent Thalassemia until Gene Therapy Strategies Are Proven to Be Safe

The authors review current critical points of hematopoietic stem cell transplantation using alternative donors and assessing recently reported safety issues of gene therapy methods, and conclude that, although a breakthrough, the safety of gene therapy remains to be established.
[Bone Marrow Transplantation]

Abstract

Clinical Features, Pathophysiology and Therapy of Poor Graft Function Post Allogeneic Stem Cell Transplantation

The pathophysiology of poor graft function can be conceptualized as dysfunction related to the number or productivity of the stem cell compartment, defects in bone marrow microenvironment components such as mesenchymal stromal cells and endothelial cells, or immunological suppression of post allogeneic stem cell transplant hematopoiesis.
[Blood Advances]

Abstract

INDUSTRY AND POLICY NEWS

City of Hope Trial Is First to Test an Investigational COVID-19 Vaccine in Immunocompromised Bone Marrow Transplant and Cellular Therapy Patients with Blood Cancers

City of Hope is now enrolling patients in a Phase II clinical trial of its COH04S1 vaccine that is the first to study the safety and effectiveness of an investigational vaccine in blood cancer patients who have received a bone marrow transplant or CAR T therapy.
[City of Hope (BusinessWire, Inc.)]

Press Release

First Patients Given Novel Cell Therapy in Leukemia Trial

GammaDelta Therapeutics announced that it has initiated a First-in-Human Phase I clinical trial in the US, evaluating a unique gamma-delta T cell therapy for the treatment of acute myeloid leukemia.
[The Francis Crick Institute]

Press Release

Intellia Therapeutics Announces US FDA Acceptance of Investigational New Drug Application for NTLA-5001, Its CRISPR/Cas9-Engineered TCR-T Cell Candidate for Acute Myeloid Leukemia

Intellia Therapeutics, Inc. announced that the US FDA has accepted the investigational new drug application for NTLA-5001, the company’s first wholly-owned ex vivo CRISPR genome editing candidate for the treatment of cancer.
[Intellia Therapeutics, Inc.]

Press Release

FEATURED EVENT

Harnessing Features of Adaptive NK Cells to Generate iPSC-Derived NK Cells for Enhanced Immunotherapy

A Randomized Phase II Trial of Idiotype Vaccination and Adoptive Autologous T Cell Transfer in Multiple Myeloma Patients

Ectopic Activation of the miR-200c–EpCAM Axis Enhances Antitumor T Cell Responses in Models of Adoptive Cell Therapy

Biological Resurfacing in a Canine Model of Hip Osteoarthritis

Three-Dimensional Covalent Organic Frameworks with Cross-Linked Pores for Efficient Cancer Immunotherapy

Combine and Conquer: Manganese Synergizing Anti-TGF-β/PD-L1 Bispecific Antibody YM101 to Overcome Immunotherapy Resistance in Non-Inflamed Cancers

Mesenchymal Stromal Cells as Carriers of IL-12 Reduce Primary and Metastatic Tumors of Murine Melanoma

Effects of Single and Multiple Transplantations of Human Umbilical Cord Mesenchymal Stem Cells on the Recovery of Ovarian Function in the Treatment of Premature Ovarian Failure in Mice

First-in-Human Clinical Trial of Transplantation of iPSC-Derived NS/PCs in Subacute Complete Spinal Cord Injury: Study Protocol

Pharmacokinetically Guided, Once-Daily Intravenous Busulfan in Combination with Fludarabine for Elderly AML/MDS Patients as a Conditioning Regimen for Allogeneic Stem Cell Transplantation

Evaluate the Presentation of Mutant KRAS Peptides on Individual HLA-I Molecules Using Targeted Mass Spectrometry and Identify 13 Unpublished KRASG12C/D/R/V Mutation/HLA-I Pairs and Nine Previously Described Pairs.

Mesenchymal Stem Cells Act as Stimulators of Neurogenesis and Synaptic Function in a Rat Model of Alzheimer’s Disease

HSCT Remains the Only Cure for Patients with Transfusion-Dependent Thalassemia until Gene Therapy Strategies Are Proven to Be Safe

Clinical Features, Pathophysiology and Therapy of Poor Graft Function Post Allogeneic Stem Cell Transplantation

City of Hope Trial Is First to Test an Investigational COVID-19 Vaccine in Immunocompromised Bone Marrow Transplant and Cellular Therapy Patients with Blood Cancers

First Patients Given Novel Cell Therapy in Leukemia Trial

Intellia Therapeutics Announces US FDA Acceptance of Investigational New Drug Application for NTLA-5001, Its CRISPR/Cas9-Engineered TCR-T Cell Candidate for Acute Myeloid Leukemia

Eurotox

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Research Fellow – Gene Therapy for Refractory Epilepsy

Scientist – Mesenchymal Stem Cell Lineages

Assistant Professor – Tumor Immunology and Experimental Immunotherapy

Biomedical Engineering – Biomaterials, Organoids, and Organ-on-a-Chip

Advanced Practice Provider – Stem Cell Transplantation

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