 | | Vol. 22.36 – 18 October, 2021 |
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| Researchers conducted a Phase I trial in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia to test AUTO3, autologous transduced T cells expressing both anti-CD19 and anti-CD22 CARs.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release.
[Science Advances] |
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| Neural-stem cells were isolated from parthenogenetic lizard embryos, rendered unresponsive to Hedgehog signaling via CRISPR/Cas9 gene knockout of smoothened, and implanted back into clonally-identical adults to regulate tail regeneration.
[Nature Communications] |
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| To gain insight into the signaling determinants of effector-associated DNA methylation programming among CD8 T cells, scientists explored the role of interleukin-12 in the imprinting of IFNg expression during CD8 T cell priming.
[Cell Reports] |
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| The combination of venetoclax and azacitidine has resulted in high response rates in the upfront treatment of acute myeloid leukemia (AML) in patients age > 75 and patients unfit for intensive chemotherapy. The authors reported outcomes of stem cell transplant-eligible patients treated at their center.
[Bone Marrow Transplantation] |
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| Patients who received standard CAR T cell therapy experienced numerous symptoms related to disease and CAR T cell therapy, including symptoms related to the T cell infusion.
[Seminars in Oncology] |
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| Scientists showed that systemic delivery of tumor-associated antigens facilitated in vivo priming and expansion of previously non-activated T cells and enhanced the cytotoxicity of activated T cells.
[Scientific Reports] |
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| Investigators retrospectively analyzed 55 patients who underwent allogeneic stem cell transplantation for mantle cell lymphoma relapsed or refractory after rituximab and high-dose cytarabine within the MANTLE-FIRST project.
[Leukemia & Lymphoma] |
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| The authors analyzed the outcomes of 483 patients who received hematopoietic stem cell transplantation between August 2017 and August 2020 in a retrospective study, comparing the outcomes between those who received cryopreserved or fresh peripheral blood stem cell grafts.
[European Journal of Haematology] |
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| Scientists discuss the current approach to various clinical issues and how emerging novel therapeutics hold promise to advance transplant care for patients with non-malignant diseases.
[Blood] |
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| Investigators highlight the preclinical and clinical efforts made for addressing the drawbacks and also review additional potent stratagems that could improve CAR-T therapy in T cell malignancies.
[Stem Cell Research & Therapy] |
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| The authors provide an overview of the cellular therapies available for the management of systemic sclerosis, including systemically injected therapies and locally administered regenerative cell therapies.
[Bone Marrow Transplantation] |
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| Century Therapeutics and Outpace Bio announced a research collaboration in CAR engineering. The collaboration will bring together Century’s CAR and protein engineering expertise with Outpace’s protein design and synthetic biology capabilities to enhance CAR functionality.
[Century Therapeutics (GlobeNewswire, Inc.)] |
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| Smart Immune SAS, a T cell medicine company utilizing its proprietary ex vivo biomimetic “thymus in a dish” technology to develop allogeneic T cell progenitors Smart101 for rapid immune reconstitution, announced that the institutional review board (IRB) of the Memorial Sloan Kettering Cancer Center has approved the commencement of the company’s Phase I/II clinical trial.
[Smart Immune SAS] |
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| October 26 – 28, 2021
Virtual |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | The International Society for Cell & Gene Therapy – Vancouver, British Columbia, Canada |
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| | Boehringer Ingelheim – Biberach, Germany |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | King Abdullah University of Science and Technology – Thuwal, Saudi Arabia |
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