 | | Vol. 22.38 – 1 November, 2021 |
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| While hematopoietic-specific Cited2 deletion has a minor impact on steady-state hematopoiesis, Cited2-deficient hematopoietic stem cells are severely depleted in young mice and fail to expand upon aging.
[Stem Cell Reports] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors investigated whether the injection of autologous mesenchymal stem cells halted muscle-to-fat conversion after tendon repair in a large animal model for rotator cuff tendon release via regional effects on extracellular fat tissue and muscle fiber regeneration.
[American Journal of Sports Medicine] |
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| Scientists retrospectively analyzed 143 patients treated with CART19 to evaluate the effect of peripheral leukemia burden at time of apheresis.
[Molecular Therapy-Methods & Clinical Development] |
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| Cell-free DNA isolated from 74 blood samples of 12 patients during lymphoma treatment with the anti-CD19 CAR-T cell product axicabtagene ciloleucel were analyzed.
[Molecular Therapy-Methods & Clinical Development] |
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| Researchers applied the recently established mixed neuroglial primary cell culture of the rat superficial dorsal horn (SDH) to investigate effects of adipose mesenchymal stem cells on the inflammatory response of SDH cells.
[Molecular Neurobiology] |
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| Investigators elucidated whether regulation of growth hormone secretagogue receptor-1a (GHS-R1a), one of the ghrelin receptors, improved the therapeutic effects of islet transplantation using -GHRP-6, a specific GHS-R1a antagonist.
[Scientific Reports] |
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| After induction of the Alzheimer’s disease model, the rats were transplanted with deferoxamine-preconditioned adipose-derived mesenchymal stem cells or untreated cells.
[Life Sciences] |
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| Scientists explored 51 variants within 17 DNA-repair genes for their association with acute graft versus host disease grades two–four in 60 pediatric patients.
[Pharmacogenomics Journal] |
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| Investigators introduced a rat model of liver fibrosis and trans-portal transplantation of human liver stem cells to demonstrate alleviation of liver fibrosis.
[International Journal of Stem Cells] |
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| Scientists focus on recent engineering and translational advances for therapeutics that genetically fuse antibodies to disease-relevant payloads, including cytokines, toxins, enzymes, neuroprotective agents, and soluble factor traps.
[Trends in Pharmacological Sciences] |
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| The authors review the progress in defining the key developmental and functional attributes of type 1 conventional dendritic cells (cDC1s) and the approaches to optimizing the potency of cDC1s for anticancer immunity.
[Trends in Immunology] |
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Investigators provide a concise overview of the main principles and potential of cell tracking, followed by a discussion of the clinically relevant labeling strategies and their application in adoptive T cell therapies (ACT).
[Drug Discovery Today] |
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| Talaris Therapeutics, Inc. announced that the first patient has been dosed in the FREEDOM-1 Phase III clinical trial of FCR001 in living donor kidney transplant recipients.
[Talaris Therapeutics, Inc.] |
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| Work led by Dr. John Maher at the School of Cancer & Pharmaceutical Sciences and in Leucid Bio sees the team genetically reprogram T cells to recognise and destroy cancer cells. This is done by inserting a gene that enables the T cell to make a new protein called a CAR.
[King’s College London] |
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| | Sarepta Therapeutics, Inc. – Columbus, Ohio, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Gordian Biotechnology – San Francisco, California, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Hong Kong University – Hong Kong, China |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
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Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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