 | | Vol. 22.38 – 8 November, 2021 |
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| The authors developed third-generation anti-CD123 CAR T cells with a humanized CSL362-based ScFv and a CD28-OX40-CD3ζ intracellular signaling domain.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that the 4-1BB CSD-associated tonic signal yielded a more dramatic effect in CAR-Tregs than in CAR-conventional T cells with respect to activation and proliferation.
[Nature Communications] |
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| Both transplantation of wild-type bone marrow and adoptive transfer of wild-type Treg cells could prevent liver injury in AMP-activated protein kinase alpha 1 (AMPKα1)-KO mice.
[Cellular & Molecular Immunology] |
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| Scientists reported on 318 patients with acute leukemia, receiving donor lymphocyte infusion in complete hematologic remission after allogeneic stem cell transplantation.
[Bone Marrow Transplantation] |
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| Using a non-viral piggyBac transposon technology and human peripheral blood derived primary natural killer (NK) cells, the authors generated CAR-NK cells to target NKG2D ligands.
[Molecular Therapy-Methods & Clinical Development] |
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| Researchers found a dramatic decrease in general oxygen consumption in hemi-ovaries submitted to cryopreservation and/or transplantation.
[Scientific Reports] |
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| The authors produced a quickly formed human iPSC-retinal pigment epithelium (RPE) strip in as short as 2 days, which showed a potency to partly expand with the correct apical/basal polarity in vivo, although limited in expansion area in the presence of healthy host RPE.
[Scientific Reports] |
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| The authors investigated the ability of transplanted human umbilical cord-mesenchymal stem cell to survive and migrate within the vitreous cavity and their neuroprotective effects on chronic glaucomatous retina.
[Stem Cells International] |
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| Investigators developed a fluid-driven heart pouch with a memory-shaped microfabricated lattice structure inspired by origami. The pore size of the membrane was around 0.4 μm, which allowed for the penetration of growth factors and exosomes.
[Med] |
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| A spate of recent studies investigating tumor immune evasion through the application of CRISPR-based gene-editing screens have highlighted tumor necrosis factor (TNF)-mediated killing as an important component of the mammalian T cell antitumor repertoire.
[Trends in Immunology] |
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| Data indicates that systemic and local chemo/radiotherapy regimens promote intratumoral cytokine and chemokine upregulation, tumor antigen presentation and cross presentation, infiltration and in situ T cells reactivation.
[Current Opinion in Immunology] |
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| Vitti Labs announced that the US FDA has approved its Investigational New Drug (IND) application to conduct Phase II Clinical Trials using a combination of umbilical cord mesenchymal stem cell and umbilical cord mesenchymal stem cell exosomes.
[Vitti Labs (PR Newswire, Inc.)] |
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| German independent research institute BioMed X announced the successful completion of the research project DNA Damage in Cancer in collaboration with Merck KGaA, Darmstadt, Germany.
[Bio MX] |
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| November 22 – 24, 2021
Virtual |
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| | Pfizer – Chesterfield, Missouri, United States |
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| | Sarepta Therapeutics, Inc. – Columbus, Ohio, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Gordian Biotechnology – San Francisco, California, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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