Cell Therapy News Volume 22.39 | Nov 15 2021

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    2021-11-15 | CTN 22.39


    Cell Therapy News by STEMCELL Technologies
    Vol. 22.39 – 15 November, 2021
    TOP STORY

    Multispecific Targeting of Glioblastoma with Tumor Microenvironment-Responsive Multifunctional Engineered NK Cells

    Scientists described a unique, sophisticated combinatorial platform for glioblastoma multiforme (GMB): a cooperative multifunctional immunotherapy based on genetically engineered human NK cells bearing multiple antitumor functions including local tumor responsiveness that addressed key drivers of GBM resistance to therapy.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    An ISSCR 2021 Innovation Showcase Webinar: Quality by Design in hPSC Cell Therapy, presented by Lynn Csontos & Kimberly Snyder. Click to Watch Now.
    PUBLICATIONSRanked by the impact factor of the journal

    Cardiovascular Events in Patients Treated with Chimeric Antigen Receptor T Cell Therapy for Aggressive B Cell Lymphoma

    The authors retrospectively reviewed the characteristics and outcomes of adult patients with relapsed/refractory large B cell lymphoma treated with standard of care axicabtagene ciloleucel or tisagenlecleucel.
    [Haematologica]

    Abstract

    CD33-Directed Immunotherapy with Third-Generation Chimeric Antigen Receptor T Cells and Gemtuzumab Ozogamicin in Intact and CD33-Edited Acute Myeloid Leukemia and Hematopoietic Stem and Progenitor Cells

    Investigators introduced a CD33-directed third-generation CAR T cell product for the treatment of patients with acute myeloid leukemia.
    [International Journal of Cancer]

    Abstract

    Intratumoral DNA-Based Delivery of Checkpoint-Inhibiting Antibodies and Interleukin 12 Triggers T Cell Infiltration and Anti-tumor Response

    In the MC38 tumor model, combined administration of plasmids encoding IL-12 and an anti-PD-1 antibody induced significant anti-tumor responses, yet similar to the monotherapies.
    [Cancer Gene Therapy]

    Abstract

    Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome

    Investigators evaluated the effects of human umbilical cord mesenchymal stem cell-conditioned medium in a new in vitro model of neurons differentiated from Dravet syndrome patient-derived iPSCs.
    [Molecular Neurobiology]

    Abstract

    Contextual Reprogramming of CAR-T Cells for Treatment of HER2+ Cancers

    Researchers created a CAR-T that united in one product the two modalities: a CRISPR interference- circuit prevents programmed cell death protein 1 expression upon antigen-encounter.
    [Journal of Translational Medicine]

    Full Article

    Transplantation of Rat Cranial Bone-Derived Mesenchymal Stem Cells Promotes Functional Recovery in Rats with Spinal Cord Injury

    Scientists determined the effect of transplanting rat cranial bone-derived MSCs (rcMSCs) in rat spinal cord injury models. The transplantation of rcMSCs improved motor function and electrophysiology recovery, and reduced cavity ratio.
    [Scientific Reports]

    Full Article

    Single Nucleotide Polymorphisms within HLA Region Are Associated with the Outcomes of Unrelated Cord Blood Transplantation

    The genomic regions ranging from 500 base pairs upstream to 500 base pairs downstream of the eight SNPs that were reported as transplantation determinants by Petersdorf et al. were analyzed to evaluate whether genetic variants were associated with the survival status of patient
    [Scientific Reports]

    Full Article

    Repairing Cartilage with Processed Chondrocyte Constructs: A 6-Month Study Using a Porcine Model

    Researchers implanted the autologous chondrocyte constructs into full-thickness chondral defects in the femoral condyle, compared those results with empty and acellular scaffold controls, and compared implantation techniques with adhesive alone and with partial adhesive with suture.
    [Cartilage]

    Abstract
    Learn more about cGMP-manufactured StemSpan™-ACF Without Phenol Red for culturing hematopoietic cell therapy products
    REVIEWS

    Immunotherapies for Hepatocellular Carcinoma

    The authors provide information on the immune microenvironments underlying the response or resistance of hepatocellular carcinoma to immunotherapies.
    [Nature Reviews Clinical Oncology]

    Abstract

    Progress on siRNA-Based Gene Therapy Targeting Secondary Injury after Intracerebral Hemorrhage

    One promising strategy that has recently garnered attention is gene therapy, in particular, small interfering RNAs (siRNA), which silence specific genes responsible for destructive effects after hemorrhage.
    [Gene Therapy]

    Abstract
    INDUSTRY AND POLICY NEWS

    EdiGene Enters Research Collaboration with the University of Wisconsin-Madison on In Vivo RNA Editing Therapies

    EdiGene, Inc. has entered into a research collaboration with the University of Wisconsin–Madison as part of the company’s effort of translating proprietary LEAPER™ RNA editing technology into in vivo therapies.
    [EdiGene, Inc.]

    Press Release

    Humanigen Announces Clinical Trial Collaboration to Evaluate Lenzilumab in Acute Graft versus Host Disease

    Humanigen, Inc. announced its plans to support a Phase II/III study to evaluate lenzilumab for the early treatment of acute graft versus host disease following allogeneic hematopoietic stem cell transplantation in collaboration with IMPACT.
    [Humanigen, Inc.]

    Press Release
    FEATURED EVENT

    5th NASH Summit 2021

    November 19 – December 2, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Faculty Positions – Cancer Research

    Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States

    Scientist – Gene Therapy Research

    Sarepta Therapeutics, Inc. – Columbus, Ohio, United States

    Postdoctoral Research Fellow – Tumor Microenvironment

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Director – Liver Biology

    Gordian Biotechnology – San Francisco, California, United States

    Associate Professor – Translational Skin Cancer

    Columbia University Medical Center – New York, New York, United States

    > See All Jobs

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