 | | Vol. 13.01 – 17 January, 2022 |
| |
|
|
| Researchers demonstrated that subcutaneous delivery via poly(ethylene glycol)-b-poly(propylene sulfide) polymersome nanocarriers significantly altered rapamycin’s cellular biodistribution to repurpose its mechanism of action for tolerance, instead of immunosuppression, and minimize side effects.
[Nature Nanotechnology] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators developed a B cell-activating factor (BAFF) ligand-based CAR and generated BAFF CAR-T cells using a non-viral gene delivery method.
[Nature Communications] |
|
|
|
| Researchers investigated how tumor-specific murine CD8+ T cells and human tumor infiltrating lymphocytes were impacted when expanded ex vivo with the TLR9 agonist CpG.
[Journal For Immunotherapy of Cancer] |
|
|
|
| The in vivo recovery of cytomegalovirus (CMV)-specific immunity after CMV-cytotoxic T lymphocytes (CTL) infusion was comparable in two groups. A detailed analysis of the source of recovered CMV-CTLs showed the proliferation and expansion of graft-derived endogenous CMV-CTLs in both groups.
[Cellular & Molecular Immunology] |
|
|
|
| Investigators showed that Tubastatin A, an Hdac6 inhibitor, prevented primary cilium resorption, maintained quiescence, and enhanced skeletal muscle stem cells survival ex vivo.
[Stem Cell Reports] |
|
|
|
| The authors stably induced retinal pigment epithelium-like cells from human fibroblasts by conditional overexpression of both broad plasticity and lineage-specific transcription factors.
[Stem Cell Reports] |
|
|
|
| Neural progenitor cell (NPC) transplantation, combined with physical exercise, showed significant improvement in both structural and behavioral outcomes in stroke-damaged rats.
[Stem Cell Reports] |
|
|
|
| Clonal hematopoiesis wassociated with increasing age and with a factor 6 increase in the risk of developing therapy-related myeloid neoplasms following autologous stem cell transplantation.
[Bone Marrow Transplantation] |
|
|
|
| Investigators constructed a CAR targeting interleukin-13 receptor α2 according to a murine antibody, and then humanized the single-chain variable fragment sequence to generate another CAR.
[Molecular Therapy-Oncolytics] |
|
|
|
| Scientists performed a randomized, controlled study to investigate the effects of mesenchymal stem cell injection for treating partial tears in the supraspinatus tendon.
[Scientific Reports] |
|
|
|
| Researchers used an integrative computational-experimental approach to elucidate the natural history of neovessel formation in a large animal preclinical model.
[Communications Medicine] |
|
 |
|
|
|
| The authors provide a futher understanding of the therapeutic role of neural stem cells for ischemic stroke, and evaluate their prospects for future application in clinical patients of ischemic stroke.
[Translational Stroke Research] |
|
|
|
| CAR-T cell therapy and oncolytic viruses are innovative cancer therapeutic approaches with fewer complications than common treatments such as chemotherapy and radiotherapy and significantly improve the quality of life.
[World Journal of Surgical Oncology] |
|
|
|
|
| Century Therapeutics and Bristol Myers Squibb announced a research collaboration and license agreement to develop and commercialize up to four iPSC derived, engineered natural killer cell and / or T cell programs for hematologic malignancies and solid tumors.
[Century Therapeutics] |
|
|
|
| Sana Biotechnology, Inc. announced that the company entered into an agreement with the National Cancer Institution, an institute of the National Institutes of Health, for worldwide exclusive commercial rights to the NIH’s CD22 CAR with a fully-human binder for use in certain in vivo gene therapy and ex vivo allogeneic CAR T applications for B cell malignancies.
[Sana Biotechnology, Inc.] |
|
|
|
| Researchers at the University of York in the UK have been awarded a $3.1 million grant to accelerate research supporting stem cell gene therapy to treat sickle cell disease.
[Sickle Cell Disease News] |
|
|
|
|
| February 6 – 10, 2022
Banff, Alberta, Canada |
|
|
|
|
|
| RWTH Aachen Medical School – Aachen, Germany |
|
|
|
| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
|
|
|
| | National Institute of Health – Rockville, Maryland, United States |
|
|
|
| Queen Mary University of London – London, United Kingdom |
|
|
|
| | Memorial Sloan Kettering – New York City, New York, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
