 | | Vol. 13.02 – 24 January, 2022 |
| |
|
|
| Low serum magnesium levels were associated with more rapid disease progression and shorter overall survival in CAR T cell and immune checkpoint antibody-treated patients.
[Cell] |
|
 |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists presented comprehensive, long-term follow-up results for eight patients with Wiskott–Aldrich syndrome having undergone a Phase I/II lentiviral vector-based gene therapy trial, with a focus on thrombocytopenia and autoimmunity.
[Nature Medicine] |
|
|
|
| The authors showed that multiple carcinomas expressed extracellular N-glycans, whose abundance negatively correlated with CAR T cell killing.
[Science Translational Medicine] |
|
|
|
| Researchers engineered a SASC system which mimicked the paracrine effect of the stem cell secretome and provided tailorability of the composition for targeted tissue regeneration.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| To mitigate antigen escape and potentially improve the durability of remission, scientists developed a dual-targeting approach using an optimized, bispecific CAR construct that targets both CD19 and BAFF-R.
[Leukemia] |
|
|
|
| Transplanting SUPT4H1-edited Huntington’s disease (HD)-induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) into the YAC128 HD transgenic mouse model improved motor function compared to unedited HD iPSC-NPCs.
[NPJ Regenerative Medicine] |
|
|
|
| Researchers examined whether serum levels of neurofilament light chain, a marker of neuroaxonal injury, correlated with the severity of immune effector cell-associated neurotoxicity syndrome.
[Blood Advances] |
|
|
|
| Scientists addressed the contribution of posttranscriptional regulation, by the RNA-binding protein CPEB4, to intestinal immune homeostasis and its role in inflammatory bowel diseases and colorectal cancer development.
[iScience] |
|
|
|
| Investigators reported a new approach that enables the formation of self-assembled 3D spheroids of adipose-derived stem cells and murine hepatocytes via reconstituted collagen fibers.
[Scientific Reports] |
|
|
|
| Using a rat cervical hemicontusion model, the authors evaluated the survival and integration of human iPSC-derived spinal motor neurons and oligodendrocyte progenitor cells.
[Frontiers in Cellular Neuroscience] |
|  |
|
|
|
| Natural killer (NK) cells lend themselves to off-the-shelf applications owing to their favorable safety profile and retained efficacy in an allogeneic setting.
[Trends in Molecular Medicine] |
|
|
|
| Fetal B-1 and B-2 B cells involved in innate and adaptive immune responses, respectively, arise in staggered waves of development from distinct progenitors.
[Pediatric Research] |
|
|
|
| The authors review recent advances and ongoing challenges in pediatric brain cancer immunotherapy, as well as considerations for efficient clinical translation of efficacious immunotherapies into pediatric settings.
[Nature Cancer] |
|
|
|
|
| EdiGene, Inc. announced a research and development collaboration with Haihe Laboratory of Cell Ecosystem to develop hematopoietic stem cell regenerative therapies and platform technology by combining resources and expertise from both sides.
[EdiGene, Inc.] |
|
|
|
| Keio University in Tokyo said it has started the world’s first clinical test using induced pluripotent stem cells, or iPS cells, to treat patients with spinal cord injuries.
[Kyodo News] |
|
|
|
|
| February 10 – 12, 2022
Lorne, Victoria, Australia |
|
|
|
|
|
| | Kyverna Therapeutics, Inc. – Emeryville, California, United States |
|
|
|
| RWTH Aachen Medical School – Aachen, Germany |
|
|
|
| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
|
|
|
| | National Institute of Health – Rockville, Maryland, United States |
|
|
|
| Queen Mary University of London – London, England, United Kingdom |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
