Cell Therapy News Volume 23.03 | Jan 31 2022

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    Justin.choi
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    2022-01-31 | CTN 23.03


    Cell Therapy News by STEMCELL Technologies
    Vol. 23.03 – 31 January, 2022
    TOP STORY

    In Vitro Matured Human Pluripotent Stem Cell-Derived Cardiomyocytes Form Grafts With Enhanced Structure and Function in Injured Hearts

    The authors comprehensively phenotyped human PSC-cardiomyocytes after in vitro maturation for 20 and 40 days on either polydimethylsiloxaneor standard tissue culture plastic substrates.
    [Circulation]

    Abstract
    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    Recruitment and Activation of Type 3 Innate Lymphoid Cells Promote Antitumor Immune Responses

    Scientists found that CCR6+ type 3 innate lymphoid cells could trigger an increase in the number of T cells infiltrating a tumor.
    [Nature Immunology]

    Abstract

    Tracking Cell Viability for Adipose-Derived Mesenchymal Stem Cell-Based Therapy by Quantitative Fluorescence Imaging in the Second Near-Infrared Window

    Researchers developed an activated near-infrared II fluorescent nanoparticle consisting of lanthanide-based down-conversion nanoparticles and IR786s for cell labeling and real-time tracking of adipose-derived mesenchymal stem cell viability in vivo.
    [ACS Nano]

    AbstractGraphical Abstract

    Identification of Shared Tumor Epitopes from Endogenous Retroviruses Inducing High-Avidity Cytotoxic T Cells for Cancer Immunotherapy

    Six candidates among the most commonly shared HLA-A2 epitopes with evidence of translation were selected for immunological evaluation. In vitro priming assays confirmed the immunogenicity of these epitopes, which induced high-avidity CD8+ T cell clones.
    [Science Advances]

    Full Article

    CAR T Cells Redirected to Cell Surface GRP78 Display Robust Anti-Acute Myeloid Leukemia Activity and Do Not Target Hematopoietic Progenitor Cells

    To target GRP78, scientists generated T cell expressing a GRP78-specific peptide-based CAR, which showed evidence of minimal fratricide post activation/transduction and antigen-dependent T cell differentiation.
    [Nature Communications]

    Abstract

    CD81 Costimulation Skews CAR Transduction toward Naive T Cells

    Researchers investigated a method to skew CAR transduction toward naive T cells without physical cell sorting.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Matrix Vesicles from Dental Follicle Cells Improve Alveolar Bone Regeneration via Activation of the PLC/PKC/MAPK Pathway

    The authors explored the therapeutic benefits of matrix vesicles, a subtype of extracellular vesicles, containing mineralizing-related biomolecules and play an important role in osteogenesis and expect to find an optimized strategy for matrix vesicle application.
    [Stem Cell Research & Therapy]

    Full Article

    An In Vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-Clinical Animal Models

    Investigators described the use of an mesenchymal stem/stromal cell-based delivery system for the secretion of a Zinc Finger protein in transgenic mouse models and young rhesus monkeys.
    [Frontiers in Molecular Neuroscience]

    Full Article

    Autologous NK Cells as Consolidation Therapy Following Stem Cell Transplantation in Multiple Myeloma

    Researchers demonstrated the feasibility of infusing multiple doses of ex vivo activated and expanded autologous NK cells in patients with multiple myeloma post-autologous stem cell transplantation.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract
    Find the Right Antibodies for Your Stem Cell Research. Learn More
    REVIEWS

    Bioengineering Strategies for Restoring Vision

    Investigators highlight the most promising gene therapies, cell therapies and retinal prostheses for the treatment of retinal disease.
    [Nature Biomedical Engineering]

    Abstract

    Chimeric Antigen Receptor Engineered T Cells and Their Application in the Immunotherapy of Solid Tumors

    With several hundred clinical trials undergoing worldwide, the pace that CAR-T immunotherapy moves from bench to bedside is unprecedented.
    [Expert Reviews in Molecular Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    US FDA Approves New Label Update for CAR T-Cell Therapy Yescarta® Showing Prophylactic Steriod Use Improves Management of Cytokine Release Syndrome

    Kite announced the FDA approved an update to the prescribing information for Yescarta® to include use of prophylactic corticosteroids across all approved indications.
    [Kite]

    Press Release

    OSE Immunotherapeutics Announces Acceptance of the US Investigational New Drug (IND) Application Obtained by Veloxis Pharmaceuticals, Inc., its Partner in Transplantation, for CD28 Antagonist VEL-101/FR104

    OSE Immunotherapeutics announced acceptance of the IND obtained by Veloxis Pharmaceuticals, Inc. from the FDA for a clinical trial with VEL-101/FR104, a CD28 antagonist monoclonal antibody fragment.
    [OSE Immunotherapeutics]

    Press Release
    FEATURED EVENT

    European Society for Blood and Marrow Transplant (EBMT)

    March 19 – 23, 2022
    Prague, Czech Republic & Online

    > See All Events

    JOB OPPORTUNITIES

    PhD Scholarship – Tissue Engineering & Scaffold Design

    Nanyang Technological University – Singapore, Singapore

    Postdoctoral Position – Regenerative Medicine

    Stanford University – Stanford, California, United States

    Postdoctoral Scholar – Tumor Immunology

    Moffit Cancer Center – Tampa Bay, Florida, United States

    Postdoctoral Fellow – Immunology, Immunotherapy, Brain Cancer

    National Cancer Institute – Bethesda, Maryland, United States

    Postdoctoral Position – NK Cell Therapy

    Oslo University Hospital – Oslo, Norway

    > See All Jobs

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