Cell Therapy News Volume 23.04 | Jan 7 2022

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    Justin.choi
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    2022-02-07 | CTN 23.04


    Cell Therapy News by STEMCELL Technologies
    Vol. 23.04 – 7 February, 2022
    TOP STORY

    Decade-Long Leukemia Remissions with Persistence of CD4+ CAR T Cells

    The authors studied long-lasting CD19-redirected CAR T cells in two patients with chronic lymphocytic leukaemia who achieved a complete remission in 2010CAR T cells remained detectable more than ten years after infusion, with sustained remission in both patients.
    [Nature]

    Abstract
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    Human Pluripotent Stem Cell-Derived Islets Ameliorate Diabetes in Non-Human Primates

    Researchers generated islets from human chemically induced pluripotent stem cell (hCiPSC-islets) and showed that a one-dose intraportal infusion of hCiPSC-islets into diabetic non-human primates effectively restored endogenous insulin secretion and improved glycemic control.
    [Nature Medicine]

    Abstract

    In Vivo Tracking of Unlabelled Mesenchymal Stromal Cells by Mannose-Weighted Chemical Exchange Saturation Transfer MRI

    The authors showed that high-mannose N-linked glycans could serve as a biomarker for the label-free tracking of transplanted human mesenchymal stem cells by mannose-weighted chemical exchange saturation transfer magnetic resonance imaging.
    [Nature Biomedical Engineering]

    Abstract

    In Vivo Imaging of Nanoparticle-Labeled CAR T Cells

    Scientists developed a clinically translatable approach for labeling CAR T cells with iron oxide nanoparticles, which enabled the noninvasive detection of the iron-labeled T cells with magnetic resonance imaging, photoacoustic imaging, and magnetic particle imaging.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    CD38 Knockout Natural Killer Cells Expressing an Affinity Optimized CD38 Chimeric Antigen Receptor Successfully Target Acute Myeloid Leukemia with Reduced Effector Cell Fratricide

    Researchers developed a CD38 CAR-NK cell therapy for acute myeloid leukemia, first by using an NK cell line which had low baseline CD38 expression and subsequently NK cells expanded from healthy donors.
    [Haematologica]

    Full Article

    Anti-CD19 and Anti-BCMA CAR T Cell Therapy Followed by Lenalidomide Maintenance after Autologous Stem-Cell Transplantation for High-Risk Newly Diagnosed Multiple Myeloma

    A single-arm exploratory clinical trial is the first to evaluate the safety and efficacy of sequential anti-CD19 and anti-BCMA CAR-T cell infusion, followed by lenalidomide maintenance after autologous stem-cell transplantation in ten high-risk newly diagnosed multiple myeloma patients.
    [American Journal of Hematology]

    Abstract

    CCR2-Overexpressing Mesenchymal Stem Cells Targeting Damaged Liver Enhance Recovery of Acute Liver Failure

    By evaluating the chemokine expression profile in the liver of acute liver failure (ALF) patients and ALF mice, investigators found that CCL2 expression was highly upregulated in damaged livers, while the corresponding receptor, CCR2, was lacking in cultured mesenchymal stem cells.
    [Stem Cell Research & Therapy]

    Full Article

    Inducible Caspase-9 Suicide Gene under Control of Endogenous OCT4 to Safeguard Mouse and Human Pluripotent Stem Cell Therapy

    Scientists inserted iCasp9 gene into the endogenous OCT4 locus of human and mouse pluripotent stem cells without affecting their pluripotency. A chemical inducer of dimerization, AP1903, induced iCasp9 activation, which led to the apoptosis of specific undifferentiated PSCs in vitro and in vivo.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    REVIEWS

    The Next Wave of Cellular Immunotherapies in Pancreatic Cancer

    The authors provide an overview of current and on-going CAR T cell clinical studies in pancreatic cancer and the major challenges and strategies to improve CAR T cell efficacy.
    [Molecular Therapy-Oncolytics]

    AbstractFull ArticleGraphical Abstract

    Regenerative Medicine for Male Infertility: A Focus on Stem Cell Niche Injury Models

    In a bid to consider mesenchymal stem cells and their secretome as a therapeutic regenerative approach for idiopathic male infertility, investigators focus on the rationale of spermatogonial stem cell niche injury modeling.
    [Biomedical Journal]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    CRISPR Therapeutics and ViaCyte, Inc. Announce First Patient Dosed in Phase I Clinical Trial of Novel Gene-Edited Cell Replacement Therapy for Treatment of Type 1 Diabetes (T1D)

    CRISPR Therapeutics and ViaCyte, Inc. announced the first patient has been dosed in the Phase I clinical trial of VCTX210 for the treatment of T1D.
    [ViaCyte, Inc.]

    Press Release

    Development of RNA Therapy for Rare Movement Disorder SCA7

    Neurologist Bart van de Warrenburg, together with Willeke van Roon-Mom and Annemieke Aartsma-Rus, have been awarded 400,000 euros by the Dutch Brain Foundation. With this money they will take the first steps towards a genetic therapy for the rare hereditary movement disorder SCA7.
    [Radbound UMC]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Research Associate – Cell Immunotherapy for Blood Cancers

    Imperial College London – London, England, United Kingdom

    PhD Scholarship – Tissue Engineering & Scaffold Design

    Nanyang Technological University – Singapore, Singapore

    Postdoctoral Position – Regenerative Medicine

    Stanford University – Stanford, California, United States

    Postdoctoral Scholar – Tumor Immunology

    Moffit Cancer Center – Tampa Bay, Florida, United States

    Postdoctoral Fellow – Immunology, Immunotherapy, Brain Cancer

    National Cancer Institute – Bethesda, Maryland, United States

    > See All Jobs

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