 | | Vol. 23.05 – 14 February, 2022 |
| |
|
|
| Scientists presented the clinical experience from the first four patients with H3K27M-mutant diffuse intrinsic pontine glioma/diffuse midline glioma treated with GD2-CAR T cells at dose level 1.
[Nature] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| T cells engineered with T cell receptors (TCRs) from naturally occurring tumor antigen-specific T cells in a patient will target personal tumor-specific antigens in their tumor.
[Cell Research] |
|
|
|
| The authors unveiled the role of mesenchymal stem cells in regulating the brain sirtuin-1 (SIRT-1) levels following stroke and the involvement of SIRT-1 in regulating inflammasome signaling to reduce cellular apoptosis towards rendering neuroprotection.
[Stem Cell Reviews and Reports] |
|
|
|
| Exosomes were isolated from the dental pulp tissue and dental pulp stem cells of swine. The effects of the exosomes on stem cells from apical dental papilla were compared using CKK-8, Transwell, angiogenesis, and odontogenic induction assays.
[International Journal of Nanomedicine] |
|
|
|
| Investigators explored the impact of epigenetic modifiers and differentiation agents on leukemia cell lines of B cell origin, as well as normal B cells.
[Frontiers in Immunology] |
|
|
|
| Researchers examined if the pulmonary volatile organic compound spectrum related to primary graft dysfunction and postoperative outcomes.
[Scientific Reports] |
|
|
|
| Scientists engineered ribonucleotide reductase overexpressing human-induced pluripotent stem cell-derived cardiomyocytes as a novel cell therapy strategy to improve contractility and regeneration in myocardial infarction.
[Biophysical Journal] |
|
|
|
| Investigators explored the mechanism of human umbilical cord-mesenchymal stem cells derived exosome’s ameliorative effect on the spinal cord injury (SCI) by combining data from in vivo contusion SCI model and in vitro cell viability of PC12 cell line stimulated with lipopolysaccharide.
[Neurochemical Research] |
|
|
|
| Scientists examined the benefit of Wharton’s jelly mesenchymal stem cells derived from the human umbilical cord in wound healing in diabetic rats.
[Archives of Dermatological Research] |
|
|
|
|
| Researchers are now studying how to expand CAR T technology beyond its use in conventional polyclonal αβ T cells to address limitations to the current therapy in cancer and applications beyond it.
[Molecular Therapy] |
|
|
|
| The authors provide an overview of the major mechanisms used by tumor cells to evade immune defenses and they critically expose the most optimistic engineering strategies to make CAR-T cell therapy a solid option for solid tumors.
[Frontiers in Immunology] |
|
|
|
|
| Legend Biotech Corporation achieved two milestones under its collaboration agreement with Janssen Biotech, Inc. for ciltacabtagene autoleucel, a B cell maturation antigen-directed CAR-T therapy.
[Legend Biotech Corporation] |
|
|
|
| BioRestorative Therapies, Inc. announced that it has initiated the site selection process for its active Phase II clinical trial targeting chronic lumbar disc disease with BRTX-100, a product formulated from autologous cultured mesenchymal stem cells collected from the patient’s bone marrow.
[BioRestorative Therapies, Inc. (Globe Newswire, Inc.)] |
|
|
|
|
|
|
|
| | Babraham Institute – Babraham, England, United Kingdom |
|
|
|
| TU Dresden – Dresden, Germany |
|
|
|
| | Imperial College London – London, England, United Kingdom |
|
|
|
| | Nanyang Technological University – Singapore, Singapore |
|
|
|
| | Stanford University – Stanford, California, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
